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Xin Chen
Medical School
Xiamen University
Fujian
Language: Chinese, English
Necroptosis
Pyroptosis
Cell Death
Molecular Mechanisms
Physiological Conditions
Pathological Conditions
Super-Resolution Microscopy
Biomedical Imaging
Cell Biology
Apoptosis
Areas of Focus
- Molecular mechanisms of necroptosis and pyroptosis
- Role of cell death in physiological and pathological conditions
- Biomedical imaging with super-resolution microscopy
Work Experience
- 2011-2018 - Xiamen University, School of Life Sciences - Postdoctoral Researcher
- 2018-present - Xiamen University, School of Life Sciences - Associate Professor
Academic Background & Achievements
- 2006 - Bachelor's Degree: Xiamen University, School of Life Sciences
- 2011 - Doctorate: Chinese Academy of Sciences, Institute of Biochemistry and Cell Biology
Publications
- A Bifunctional Super-resolution Imaging Probe with Acidity-independent Lysosome-retention Mechanism, Xue Z, Wang S, Li J, Chen X*, Han J, Han S*, 2018
- ISP1-Anchored Polarization of GCβ/CDC50A Complex Initiates Malaria Ookinete Gliding Motility, Gao H, Yang Z, Wang X, Qian P, Hong R, Chen X, Su XZ, Cui H, Yuan J*, 2018
- RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis, Yang Z, Wang Y, Zhang Y, He X, Zhong CQ, Ni H, Chen X, Liang Y, Wu J, Zhao S, Zhou D, Han J*, 2018
- Plasma membrane changes during programmed cell deaths, Zhang Y, Chen X, Gueydan C, Han J*, 2018
- RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome, Zhang Y#, Su SS#, Zhao S, Yang Z, Zhong CQ, Chen X, Cai Q, Yang ZH, Huang D, Wu R, Han J*, 2017
- MLKL channel in necroptosis is octamer formed by tetramers in a dyadic process, Huang D, Zheng X, Wang ZA, Chen X, He WT, Zhang Y, Xu JG, Zhao H, Shi W, Wang X, Zhu Y, Han J*, 2017
- Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis, Chen X#, He WT#, Hu L, Li J, Fang Y, Wang X, Xu X, Wang Z, Huang K, Han J*, 2016
- Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis, Wu XN#, Yang ZH#, Wang XK, Zhang Y, Wan H, Song Y, Chen X, Shao J, Han J*, 2014
- Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death, Chen X#, Li W#, Ren J#, Huang D, He WT, Song Y, Yang C, Li W, Zheng X, Chen P, Han J*, 2014
- Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase, Chen X#, Ma JJ#, Tan M, Yao P, Hu QH, Eriani G, Wang ED*, 2011
