Professor | Xin Chen | Asia Growth Partners

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Name	Xin Chen
Language ability	Chinese, English
Province	Fujian

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Name

Xin Chen

Language ability

Chinese, English

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Medical
Academic Background & Achievements	2006 - Bachelor's Degree: Xiamen University, School of Life Sciences 2011 - Doctorate: Chinese Academy of Sciences, Institute of Biochemistry and Cell Biology
Work Experience	2011-2018 - Xiamen University, School of Life Sciences - Postdoctoral Researcher 2018-present - Xiamen University, School of Life Sciences - Associate Professor

University/Lab Affiliation and Title

Xiamen University

Faculty

Medical

Academic Background & Achievements

2006 - Bachelor's Degree: Xiamen University, School of Life Sciences
2011 - Doctorate: Chinese Academy of Sciences, Institute of Biochemistry and Cell Biology

Work Experience

2011-2018 - Xiamen University, School of Life Sciences - Postdoctoral Researcher
2018-present - Xiamen University, School of Life Sciences - Associate Professor

Areas of Focus	Molecular mechanisms of necroptosis and pyroptosis Role of cell death in physiological and pathological conditions Biomedical imaging with super-resolution microscopy
Publications	A Bifunctional Super-resolution Imaging Probe with Acidity-independent Lysosome-retention Mechanism, Xue Z, Wang S, Li J, Chen X, Han J, Han S, 2018 ISP1-Anchored Polarization of GCβ/CDC50A Complex Initiates Malaria Ookinete Gliding Motility, Gao H, Yang Z, Wang X, Qian P, Hong R, Chen X, Su XZ, Cui H, Yuan J, 2018 RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis, Yang Z, Wang Y, Zhang Y, He X, Zhong CQ, Ni H, Chen X, Liang Y, Wu J, Zhao S, Zhou D, Han J, 2018 Plasma membrane changes during programmed cell deaths, Zhang Y, Chen X, Gueydan C, Han J, 2018 RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome, Zhang Y#, Su SS#, Zhao S, Yang Z, Zhong CQ, Chen X, Cai Q, Yang ZH, Huang D, Wu R, Han J, 2017 MLKL channel in necroptosis is octamer formed by tetramers in a dyadic process, Huang D, Zheng X, Wang ZA, Chen X, He WT, Zhang Y, Xu JG, Zhao H, Shi W, Wang X, Zhu Y, Han J, 2017 Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis, Chen X#, He WT#, Hu L, Li J, Fang Y, Wang X, Xu X, Wang Z, Huang K, Han J, 2016 Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis, Wu XN#, Yang ZH#, Wang XK, Zhang Y, Wan H, Song Y, Chen X, Shao J, Han J, 2014 Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death, Chen X#, Li W#, Ren J#, Huang D, He WT, Song Y, Yang C, Li W, Zheng X, Chen P, Han J, 2014 Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase, Chen X#, Ma JJ#, Tan M, Yao P, Hu QH, Eriani G, Wang ED*, 2011

Areas of Focus

Molecular mechanisms of necroptosis and pyroptosis
Role of cell death in physiological and pathological conditions
Biomedical imaging with super-resolution microscopy

Publications

A Bifunctional Super-resolution Imaging Probe with Acidity-independent Lysosome-retention Mechanism, Xue Z, Wang S, Li J, Chen X*, Han J, Han S*, 2018
ISP1-Anchored Polarization of GCβ/CDC50A Complex Initiates Malaria Ookinete Gliding Motility, Gao H, Yang Z, Wang X, Qian P, Hong R, Chen X, Su XZ, Cui H, Yuan J*, 2018
RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis, Yang Z, Wang Y, Zhang Y, He X, Zhong CQ, Ni H, Chen X, Liang Y, Wu J, Zhao S, Zhou D, Han J*, 2018
Plasma membrane changes during programmed cell deaths, Zhang Y, Chen X, Gueydan C, Han J*, 2018
RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome, Zhang Y#, Su SS#, Zhao S, Yang Z, Zhong CQ, Chen X, Cai Q, Yang ZH, Huang D, Wu R, Han J*, 2017
MLKL channel in necroptosis is octamer formed by tetramers in a dyadic process, Huang D, Zheng X, Wang ZA, Chen X, He WT, Zhang Y, Xu JG, Zhao H, Shi W, Wang X, Zhu Y, Han J*, 2017
Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis, Chen X#, He WT#, Hu L, Li J, Fang Y, Wang X, Xu X, Wang Z, Huang K, Han J*, 2016
Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis, Wu XN#, Yang ZH#, Wang XK, Zhang Y, Wan H, Song Y, Chen X, Shao J, Han J*, 2014
Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death, Chen X#, Li W#, Ren J#, Huang D, He WT, Song Y, Yang C, Li W, Zheng X, Chen P, Han J*, 2014
Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase, Chen X#, Ma JJ#, Tan M, Yao P, Hu QH, Eriani G, Wang ED*, 2011

Necroptosis Pyroptosis Cell Death Molecular Mechanisms Physiological Conditions Pathological Conditions Super-Resolution Microscopy Biomedical Imaging Cell Biology Apoptosis

Zhanghua Yang - Zhejiang University

Xiaohui Cang - Zhejiang University

Jingjing Wu - Zhejiang University

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