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陈鑫
Medical School
厦门大学
福建
Language: 中文, 英文
坏死样凋亡
焦亡
细胞死亡
分子机制
生理条件
病理条件
超高分辨率显微镜
生物医学成像
细胞生物学
凋亡
Areas of Focus
- 坏死样凋亡和焦亡的分子机制
- 细胞死亡在生理病理情况下的角色
- 超高分辨率显微成像技术的生物医学成像
Work Experience
- 2011-2018年 - 厦门大学, 生命科学学院 - 博士后
- 2018年至今 - 厦门大学, 生命科学学院 - 副教授
Academic Background & Achievements
- 2006年 - 学士学位: 厦门大学, 生命科学学院
- 2011年 - 博士学位: 中国科学院, 生物化学与细胞生物学研究所
Publications
- A Bifunctional Super-resolution Imaging Probe with Acidity-independent Lysosome-retention Mechanism, Xue Z, Wang S, Li J, Chen X*, Han J, Han S*, 2018
- ISP1-Anchored Polarization of GCβ/CDC50A Complex Initiates Malaria Ookinete Gliding Motility, Gao H, Yang Z, Wang X, Qian P, Hong R, Chen X, Su XZ, Cui H, Yuan J*, 2018
- RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis, Yang Z, Wang Y, Zhang Y, He X, Zhong CQ, Ni H, Chen X, Liang Y, Wu J, Zhao S, Zhou D, Han J*, 2018
- Plasma membrane changes during programmed cell deaths, Zhang Y, Chen X, Gueydan C, Han J*, 2018
- RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome, Zhang Y#, Su SS#, Zhao S, Yang Z, Zhong CQ, Chen X, Cai Q, Yang ZH, Huang D, Wu R, Han J*, 2017
- MLKL channel in necroptosis is octamer formed by tetramers in a dyadic process, Huang D, Zheng X, Wang ZA, Chen X, He WT, Zhang Y, Xu JG, Zhao H, Shi W, Wang X, Zhu Y, Han J*, 2017
- Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis, Chen X#, He WT#, Hu L, Li J, Fang Y, Wang X, Xu X, Wang Z, Huang K, Han J*, 2016
- Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis, Wu XN#, Yang ZH#, Wang XK, Zhang Y, Wan H, Song Y, Chen X, Shao J, Han J*, 2014
- Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death, Chen X#, Li W#, Ren J#, Huang D, He WT, Song Y, Yang C, Li W, Zheng X, Chen P, Han J*, 2014
- Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase, Chen X#, Ma JJ#, Tan M, Yao P, Hu QH, Eriani G, Wang ED*, 2011
