Professor | Gaojie Song | Asia Growth Partners

Name	Gaojie Song
Contact Information	gjsong@bio.ecnu.edu.cn
Language ability	Chinese, English
Province	Shanghai

Name

Gaojie Song

Contact Information

gjsong@bio.ecnu.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	East China Normal University
Faculty	Life Sciences
Academic Background & Achievements	2006-2009 PhD in Structural and Molecular Biology, Institute of Biophysics, Chinese Academy of Sciences 2003-2006 Master of Science in Biochemistry and Molecular Biology, Beijing Normal University 1999-2003 Bachelor of Science in Basic Medical Sciences, Anhui Medical University
Work Experience	2018-Present Researcher at School of Life Sciences, East China Normal University 2014-2017 Associate Research Professor at iHuman Institute, ShanghaiTech University 2009-2014 Postdoctoral Fellow at Department of Biochemistry and Molecular Pharmacology, Harvard Medical School

University/Lab Affiliation and Title

East China Normal University

Faculty

Life Sciences

Academic Background & Achievements

2006-2009 PhD in Structural and Molecular Biology, Institute of Biophysics, Chinese Academy of Sciences
2003-2006 Master of Science in Biochemistry and Molecular Biology, Beijing Normal University
1999-2003 Bachelor of Science in Basic Medical Sciences, Anhui Medical University

Work Experience

2018-Present Researcher at School of Life Sciences, East China Normal University
2014-2017 Associate Research Professor at iHuman Institute, ShanghaiTech University
2009-2014 Postdoctoral Fellow at Department of Biochemistry and Molecular Pharmacology, Harvard Medical School

Areas of Focus	Structural biology of cell surface receptors, especially G protein-coupled receptors (GPCRs)
Publications	Unveiling Mechanical Activation: GAIN Domain Unfolding and Dissociation in Adhesion GPCRs, Fu C, Huang W, Tang Q, Niu M, Guo S, Langenhan T, Song G, Yan J, 2023 Structural insights into MIC2 recognition by MIC2-associated protein in Toxoplasma gondii, Zhang S, Wang F, Zhang D, Liu D, Ding W, Springer TA, Song G, 2023 Crystal Structure of the Extracellular Domains of GPR110, Wang F, Wang Y, Qiu W, Zhang Q, Yang H, Song G, 2023 Cryo-EM structure of the human adenosine A2B receptor-Gs signaling complex, Chen Y, Zhang J, Weng Y, Xu Y, Lu W, Liu W, Liu M, Hua T, Song G, 2022 Engineering a precise adenine base editor with minimal bystander editing, Chen L, Zhang S, Xue N, Hong M, Zhang X, Zhang D, Yang J, Bai S, Huang Y, Meng H, Wu H, Luan C, Zhu B, Ru G, Gao H, Zhong L, Liu M, Liu M, Cheng Y, Yi C, Wang L, Zhao Y, Song G, Li D, 2022 Crystal structure of a constitutive active mutant of adenosine A2A receptor, Cui M, Zhou Q, Xu Y, Weng Y, Yao D, Zhao S, Song G, 2022 Structural basis for CD97 recognition of the decay-accelerating factor CD55 suggests mechanosensitive activation of adhesion GPCRs, Niu M, Xu S, Yang J, Yao D, Li N, Yan J, Zhong G, Song G, 2021 Full length human GLP1 receptor structure without orthosteric ligands, Wu F, Yang L, Hang K, Laursen M, Wu L, Han GW, Ren Q, Roed NK, Lin G, Hanson MA, Jiang HL, Wang MW, Reedtz-Runge S, Song G, Stevens RC, 2020 Mutagenesis facilitated crystallization of GLP-1R, Xu Y, Wang Y, Wang Y, Liu K, Peng Y, Yao D, Tao H, Liu H, Song G, 2019 Protein crystal quality oriented disulfide bond engineering, Pu M, Xu Z, Peng Y, Hou Y, Liu D, Wang Y, Liu H, Song G, Liu ZJ, 2017 Biochemical features of the adhesion G protein-coupled receptor CD97 for its functions of auto-proteolysis and HeLa cell attachment, Yang L, Liu X, Yang Y, Tang Y, Zhang M, Tan M, Cheng S, Xu Y, Yang L, Yang H, Song G, Huang W, 2017 Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators, Song G, Yang D, Wang Y, Graaf CD, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han GW, Lau J, Wu B, Hanson MA, Liu ZJ, Wang MW, Steven RC, 2017 Structure of the full-length glucagon class B G protein-coupled receptor, Zhang H, Qiao A, Yang D, Yang L, Dai A, Graaf Cd, Reedtz-Runge S, Dharmarajan V, Zhang H, Han GW, Grant TD, Sierra R, Weierstall U, Nelson G, Liu W, Wu Y, Ma L, Cai X, Lin G, Geng Z, Dong Y, Song G, Griffin PR, Lau J, Cherezov V, Yang H, Hanson MA, Stevens RC, Jiang H, Wang MW, Zhao Q, Wu B, 2017 Extending the Structural View of Class B GPCRs, de Graaf C, Song G, Cao C, Zhao Q, Wang MW, Wu B, Stevens RC, 2017 Structures of the Toxoplasma gliding motility adhesin, Song G, Springer TA, 2014 Crystal structure of N-terminal domain of human cytokine- induced apoptosis inhibitor anamorsin, Song G, Cheng C, Li Y, Shaw N, Xiao ZC, Liu ZJ, 2014 Shape change in the receptor for gliding motility in plasmodium sporozoites, Song G, Koksal AC, Lu C, Springer TA, 2012 Structural insight into acute intermittent porphyria, Song G, Li Y, Cheng C, Zhao Y, Gao A, Zhang R, Joachimiak A, Shaw N, Liu ZJ, 2009

Areas of Focus

Structural biology of cell surface receptors, especially G protein-coupled receptors (GPCRs)

Publications

Unveiling Mechanical Activation: GAIN Domain Unfolding and Dissociation in Adhesion GPCRs, Fu C, Huang W, Tang Q, Niu M, Guo S, Langenhan T, Song G, Yan J, 2023
Structural insights into MIC2 recognition by MIC2-associated protein in Toxoplasma gondii, Zhang S, Wang F, Zhang D, Liu D, Ding W, Springer TA, Song G, 2023
Crystal Structure of the Extracellular Domains of GPR110, Wang F, Wang Y, Qiu W, Zhang Q, Yang H, Song G, 2023
Cryo-EM structure of the human adenosine A2B receptor-Gs signaling complex, Chen Y, Zhang J, Weng Y, Xu Y, Lu W, Liu W, Liu M, Hua T, Song G, 2022
Engineering a precise adenine base editor with minimal bystander editing, Chen L, Zhang S, Xue N, Hong M, Zhang X, Zhang D, Yang J, Bai S, Huang Y, Meng H, Wu H, Luan C, Zhu B, Ru G, Gao H, Zhong L, Liu M, Liu M, Cheng Y, Yi C, Wang L, Zhao Y, Song G, Li D, 2022
Crystal structure of a constitutive active mutant of adenosine A2A receptor, Cui M, Zhou Q, Xu Y, Weng Y, Yao D, Zhao S, Song G, 2022
Structural basis for CD97 recognition of the decay-accelerating factor CD55 suggests mechanosensitive activation of adhesion GPCRs, Niu M, Xu S, Yang J, Yao D, Li N, Yan J, Zhong G, Song G, 2021
Full length human GLP1 receptor structure without orthosteric ligands, Wu F, Yang L, Hang K, Laursen M, Wu L, Han GW, Ren Q, Roed NK, Lin G, Hanson MA, Jiang HL, Wang MW, Reedtz-Runge S, Song G, Stevens RC, 2020
Mutagenesis facilitated crystallization of GLP-1R, Xu Y, Wang Y, Wang Y, Liu K, Peng Y, Yao D, Tao H, Liu H, Song G, 2019
Protein crystal quality oriented disulfide bond engineering, Pu M, Xu Z, Peng Y, Hou Y, Liu D, Wang Y, Liu H, Song G, Liu ZJ, 2017
Biochemical features of the adhesion G protein-coupled receptor CD97 for its functions of auto-proteolysis and HeLa cell attachment, Yang L, Liu X, Yang Y, Tang Y, Zhang M, Tan M, Cheng S, Xu Y, Yang L, Yang H, Song G, Huang W, 2017
Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators, Song G, Yang D, Wang Y, Graaf CD, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han GW, Lau J, Wu B, Hanson MA, Liu ZJ, Wang MW, Steven RC, 2017
Structure of the full-length glucagon class B G protein-coupled receptor, Zhang H, Qiao A, Yang D, Yang L, Dai A, Graaf Cd, Reedtz-Runge S, Dharmarajan V, Zhang H, Han GW, Grant TD, Sierra R, Weierstall U, Nelson G, Liu W, Wu Y, Ma L, Cai X, Lin G, Geng Z, Dong Y, Song G, Griffin PR, Lau J, Cherezov V, Yang H, Hanson MA, Stevens RC, Jiang H, Wang MW, Zhao Q, Wu B, 2017
Extending the Structural View of Class B GPCRs, de Graaf C, Song G, Cao C, Zhao Q, Wang MW, Wu B, Stevens RC, 2017
Structures of the Toxoplasma gliding motility adhesin, Song G, Springer TA, 2014
Crystal structure of N-terminal domain of human cytokine- induced apoptosis inhibitor anamorsin, Song G, Cheng C, Li Y, Shaw N, Xiao ZC, Liu ZJ, 2014
Shape change in the receptor for gliding motility in plasmodium sporozoites, Song G, Koksal AC, Lu C, Springer TA, 2012
Structural insight into acute intermittent porphyria, Song G, Li Y, Cheng C, Zhao Y, Gao A, Zhang R, Joachimiak A, Shaw N, Liu ZJ, 2009

Gpcrs Structural Biology Signal Transduction X-Ray Crystallography Cryo-Electron Microscopy Membrane Proteins Drug Targets Protein Expression Protein Purification Crystallization

Jiawei Wang - Tsinghua University

Xueming Li - Tsinghua University

Xiaoling Yu - Southern University of Science and Technology

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