Areas of Focus
- Metabolic engineering and microbial synthetic biology for disease treatment
- Development and application of probiotic sensors
- Optogenetics
- Cancer immunotherapy
Work Experience
- 2018.10-: Associate Researcher, School of Life Sciences, East China Normal University, Team of Haifeng Ye
- 2016.03-2018.01: Postdoctoral Researcher, Georgia Institute of Technology, Team of Rachel Chen
Academic Background & Achievements
- 2010-2015 PhD in Fermentation Engineering, Jiangnan University
- Received National Natural Science Foundation of China Young Scientist Fund
- Participated in national key research program on synthetic biology
Publications
- Microbial response to acid stress: mechanisms and applications, Ningzi Guan, Long Liu, 2020
- Engineering a far-red light–activated split-Cas9 system for remote-controlled genome editing of internal organs and tumors, Yuanhuan Yu, Xin Wu, Ningzi Guan, Jiawei Shao, Huiying Li, Yuxuan Chen, Yuan Ping, Dali Li, Haifeng Ye, 2020
- A versatile genetic control system in mammalian cells and mice responsive to clinically licensed sodium ferulate, Yidan Wang, Shuyong Liao, Ningzi Guan, Yuanxiao Liu, Kaili Dong, Wilfried Weber, Haifeng Ye, 2020
- Microbial production of nutraceuticals: challenges and prospects, Ningzi Guan, Jianghua Li, Guocheng Du, Jian Chen, Long Liu, 2019
- TCA-Cycle powered synthesis of fucosylated oligosaccharides, Ningzi Guan, Hyun-Dong Shin, Lingfeng Long, Parastoo Azadi, Rachel Chen, 2018
- A high-yielding enzymatic process for production of bioactive β-1,3-glucan oligosaccharides with defined size, Ningzi Guan, Juping Yu, Wei Liu, Rachel Chen, 2018
- Comparative genomics and transcriptomics analysis-guided metabolic engineering of Propionibacterium acidipropionicifor improved propionic acid production, Ningzi Guan, Bin Du, Jianghua Li, Hyun-Dong Shin, Rachel Chen, Guocheng Du, Jian Chen, Long Liu, 2018
- Recent technology development for the biosynthesis of Human Milk Oligosaccharide, Ningzi Guan, Rachel Chen, 2018
- Microbial response to environmental stresses: from fundamental mechanisms to practical applications, Ningzi Guan, Jianghua Li, Hyun-Dong Shin, Guocheng Du, Jian Chen, Long Liu, 2017
- A DNA bubble-mediated gene regulation system based on thrombin-bound DNA aptamers, Jing Wang, Le Yang, Xun Cui, Zhe Zhang, Lichun Dong, Ningzi Guan, 2017
- A real-time control system of gene expression using ligand-bound nucleic acid aptamer for metabolic engineering, Jing Wang, Xun Cui, Le Yang, Zhe Zhang, Liping Lv, Haoyuan Wang, Zhenmin Zhao, Ningzi Guan, Lichun Dong, Rachel Chen, 2017
- Development of GRAS strains for nutraceutical production using systems and synthetic biology approaches: Advances and prospects, Long Liu, Ningzi Guan, Jianghua Li, Guocheng Du, Jian Chen, 2017
- Metabolic engineering of acid resistance elements to improve acid resistance and propionic acid production of Propionibacterium jensenii, Ningzi Guan, Jianghua Li, Hyun-Dong Shin, Guocheng Du, Jian Chen, Long Liu, 2016
- Pathway engineering of Propionibacterium jensenii for improved production of propionic acid, Long Liu, Ningzi Guan, Gexin Zhu, Jianghua Li, Hyun-Dong Shin, Guocheng Du, Jian Chen, 2016
- Comparative metabolomics analysis of the key metabolic nodes in propionic acid synthesis in Propionibacterium acidipropionici, Ningzi Guan, Gexin Zhu, Jianghua Li, Hyun-Dong Shin, Jing Wu, Zhongping Shi, Long Liu, 2015
- Engineering propionibacteria as versatile cell factories for the production of industrially important chemicals: advances, challenges, and prospects, Ningzi Guan, Gexin Zhu, Jianghua Li, Hyun-Dong Shin, Jing Wu, Zhongping Shi, Long Liu, 2015
- Understanding of how Propionibacterium acidipropionici respond to propionic acid stress at the level of proteomics, Ningzi Guan, Long Liu, Hyun-Dong Shin, Rachel Chen, Juan Zhang, Jianghua Li, Guocheng Du, Zhongping Shi, Jian Chen, 2014
- Systems-level understanding how Propionibacterium acidipropionici respond to propionic acid stress at the microenvironment levels: Mechanism and application, Ningzi Guan, Long Liu, Hyun-Dong Shin, Rachel Chen, Juan Zhang, Jianghua Li, Guocheng Du, Zhongping Shi, Jian Chen, 2013
- Genome shuffling improves acid tolerance of Propionibacterium acidipropionici and propionic acid production, Ningzi Guan, Long Liu, Gexin Zhu, Qiaoyan Xu, Jianghua Li, Guocheng Du, Jian Chen, 2012
