Professor | 管宁子 | 数字化转型顾问

Name	管宁子
Contact Information	nzguan@bio.ecnu.edu.cn
Language ability	英语, 汉语
Province	上海

Name

管宁子

Contact Information

nzguan@bio.ecnu.edu.cn

Language ability

英语, 汉语

Province

上海

University/Lab Affiliation and Title	华东师范大学
Faculty	Life Sciences
Academic Background & Achievements	2010-2015 博士，发酵工程，江南大学获得国家自然科学基金青年基金参与国家重点研究计划合成生物学专项
Work Experience	2018.10-: 副研究员，生命科学学院，华东师范大学，叶海峰团队 2016.03-2018.01: 博士后，佐治亚理工学院，Rachel Chen 团队

University/Lab Affiliation and Title

华东师范大学

Faculty

Life Sciences

Academic Background & Achievements

2010-2015 博士，发酵工程，江南大学
获得国家自然科学基金青年基金
参与国家重点研究计划合成生物学专项

Work Experience

2018.10-: 副研究员，生命科学学院，华东师范大学，叶海峰团队
2016.03-2018.01: 博士后，佐治亚理工学院，Rachel Chen 团队

Areas of Focus	代谢工程与微生物合成生物学在疾病治疗中的应用研究益生菌传感器的开发与应用光遗传学肿瘤免疫治疗
Publications	Microbial response to acid stress: mechanisms and applications, 管宁子, 刘龙, 2020 Engineering a far-red light–activated split-Cas9 system for remote-controlled genome editing of internal organs and tumors, 于元欢, 吴欣, 管宁子, 邵佳伟, 李慧英, 陈宇轩, 平远, 李大力, 叶海峰, 2020 A versatile genetic control system in mammalian cells and mice responsive to clinically licensed sodium ferulate, 王一丹, 廖书勇, 管宁子, 刘远晓, 董凯丽, Wilfried Weber, 叶海峰, 2020 Microbial production of nutraceuticals: challenges and prospects, 管宁子, 李江华, 堵国成, 陈坚, 刘龙, 2019 TCA-Cycle powered synthesis of fucosylated oligosaccharides, 管宁子, Hyun-Dong Shin, 龙凌风, Parastoo Azadi, Rachel Chen, 2018 A high-yielding enzymatic process for production of bioactive β-1,3-glucan oligosaccharides with defined size, 管宁子, 于菊萍, 刘伟, Rachel Chen, 2018 Comparative genomics and transcriptomics analysis-guided metabolic engineering of Propionibacterium acidipropionicifor improved propionic acid production, 管宁子, 杜斌, 李江华, Hyun-Dong Shin, Rachel Chen, 堵国成, 陈坚, 刘龙, 2018 Recent technology development for the biosynthesis of Human Milk Oligosaccharide, 管宁子, Rachel Chen, 2018 Microbial response to environmental stresses: from fundamental mechanisms to practical applications, 管宁子, 李江华, Hyun-Dong Shin, 堵国成, 陈坚, 刘龙, 2017 A DNA bubble-mediated gene regulation system based on thrombin-bound DNA aptamers, 王静, 杨乐, 崔迅, 张哲, 董立春, 管宁子, 2017 A real-time control system of gene expression using ligand-bound nucleic acid aptamer for metabolic engineering, 王静, 崔迅, 杨乐, 张哲, 吕丽萍, 王浩远, 赵振民, 管宁子, 董立春, Rachel Chen, 2017 Development of GRAS strains for nutraceutical production using systems and synthetic biology approaches: Advances and prospects, 刘龙, 管宁子, 李江华, 堵国成, 陈坚, 2017 Metabolic engineering of acid resistance elements to improve acid resistance and propionic acid production of Propionibacterium jensenii, 管宁子, 李江华, Hyun-Dong Shin, 堵国成, 陈坚, 刘龙, 2016 Pathway engineering of Propionibacterium jensenii for improved production of propionic acid, 刘龙, 管宁子, 朱格新, 李江华, Hyun-Dong Shin, 堵国成, 陈坚, 2016 Comparative metabolomics analysis of the key metabolic nodes in propionic acid synthesis in Propionibacterium acidipropionici, 管宁子, 朱格新, 李江华, Hyun-Dong Shin, 吴静, 石中平, 刘龙, 2015 Engineering propionibacteria as versatile cell factories for the production of industrially important chemicals: advances, challenges, and prospects, 管宁子, 朱格新, 李江华, Hyun-Dong Shin, 吴静, 石中平, 刘龙, 2015 Understanding of how Propionibacterium acidipropionici respond to propionic acid stress at the level of proteomics, 管宁子, 刘龙, Hyun-Dong Shin, Rachel Chen, 张娟, 李江华, 堵国成, 石中平, 陈坚, 2014 Systems-level understanding how Propionibacterium acidipropionici respond to propionic acid stress at the microenvironment levels: Mechanism and application, 管宁子, 刘龙, Hyun-Dong Shin, Rachel Chen, 张娟, 李江华, 堵国成, 石中平, 陈坚, 2013 Genome shuffling improves acid tolerance of Propionibacterium acidipropionici and propionic acid production, 管宁子, 刘龙, 朱格新, 徐

Areas of Focus

代谢工程与微生物合成生物学在疾病治疗中的应用研究
益生菌传感器的开发与应用
光遗传学
肿瘤免疫治疗

Publications

Microbial response to acid stress: mechanisms and applications, 管宁子, 刘龙, 2020
Engineering a far-red light–activated split-Cas9 system for remote-controlled genome editing of internal organs and tumors, 于元欢, 吴欣, 管宁子, 邵佳伟, 李慧英, 陈宇轩, 平远, 李大力, 叶海峰, 2020
A versatile genetic control system in mammalian cells and mice responsive to clinically licensed sodium ferulate, 王一丹, 廖书勇, 管宁子, 刘远晓, 董凯丽, Wilfried Weber, 叶海峰, 2020
Microbial production of nutraceuticals: challenges and prospects, 管宁子, 李江华, 堵国成, 陈坚, 刘龙, 2019
TCA-Cycle powered synthesis of fucosylated oligosaccharides, 管宁子, Hyun-Dong Shin, 龙凌风, Parastoo Azadi, Rachel Chen, 2018
A high-yielding enzymatic process for production of bioactive β-1,3-glucan oligosaccharides with defined size, 管宁子, 于菊萍, 刘伟, Rachel Chen, 2018
Comparative genomics and transcriptomics analysis-guided metabolic engineering of Propionibacterium acidipropionicifor improved propionic acid production, 管宁子, 杜斌, 李江华, Hyun-Dong Shin, Rachel Chen, 堵国成, 陈坚, 刘龙, 2018
Recent technology development for the biosynthesis of Human Milk Oligosaccharide, 管宁子, Rachel Chen, 2018
Microbial response to environmental stresses: from fundamental mechanisms to practical applications, 管宁子, 李江华, Hyun-Dong Shin, 堵国成, 陈坚, 刘龙, 2017
A DNA bubble-mediated gene regulation system based on thrombin-bound DNA aptamers, 王静, 杨乐, 崔迅, 张哲, 董立春, 管宁子, 2017
A real-time control system of gene expression using ligand-bound nucleic acid aptamer for metabolic engineering, 王静, 崔迅, 杨乐, 张哲, 吕丽萍, 王浩远, 赵振民, 管宁子, 董立春, Rachel Chen, 2017
Development of GRAS strains for nutraceutical production using systems and synthetic biology approaches: Advances and prospects, 刘龙, 管宁子, 李江华, 堵国成, 陈坚, 2017
Metabolic engineering of acid resistance elements to improve acid resistance and propionic acid production of Propionibacterium jensenii, 管宁子, 李江华, Hyun-Dong Shin, 堵国成, 陈坚, 刘龙, 2016
Pathway engineering of Propionibacterium jensenii for improved production of propionic acid, 刘龙, 管宁子, 朱格新, 李江华, Hyun-Dong Shin, 堵国成, 陈坚, 2016
Comparative metabolomics analysis of the key metabolic nodes in propionic acid synthesis in Propionibacterium acidipropionici, 管宁子, 朱格新, 李江华, Hyun-Dong Shin, 吴静, 石中平, 刘龙, 2015
Engineering propionibacteria as versatile cell factories for the production of industrially important chemicals: advances, challenges, and prospects, 管宁子, 朱格新, 李江华, Hyun-Dong Shin, 吴静, 石中平, 刘龙, 2015
Understanding of how Propionibacterium acidipropionici respond to propionic acid stress at the level of proteomics, 管宁子, 刘龙, Hyun-Dong Shin, Rachel Chen, 张娟, 李江华, 堵国成, 石中平, 陈坚, 2014
Systems-level understanding how Propionibacterium acidipropionici respond to propionic acid stress at the microenvironment levels: Mechanism and application, 管宁子, 刘龙, Hyun-Dong Shin, Rachel Chen, 张娟, 李江华, 堵国成, 石中平, 陈坚, 2013
Genome shuffling improves acid tolerance of Propionibacterium acidipropionici and propionic acid production, 管宁子, 刘龙, 朱格新, 徐

代谢工程微生物合成生物学疾病治疗益生菌传感器开发应用光遗传学癌症免疫治疗研究

朱晨光 - 上海大学

Area of Focus
代谢工程 | 生化产品 | 微生物 | 基因工程 | 污染物 | 降解 | 细菌 | 环境 | 生物防治 | 开发

管宁子 - 华东师范大学

朱晨光 - 上海大学

Area of Focus
代谢工程 | 微生物 | 生化 | 基因工程 | 污染物 | 降解 | 细菌 | 环保 | 生物防治 | 开发

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