2005-2008 Bachelor of Science in Molecular Biology: Princeton University
2009-2013 PhD in Biomedical Sciences: Harvard Medical School
Achievement: Published over 60 papers in journals like Science, Cell, Nature Medicine
2013-2017 - Genome Institute of Singapore - Group Leader
2017-present - Institute of Zoology, Chinese Academy of Sciences - Researcher, Doctoral Supervisor, Group Leader
2023: Chaoyang District Phoenix Plan Leading Talent
2022: National Science and Technology System Advanced Collective in Fighting COVID-19
2020: Chinese Academy of Sciences Outstanding Scientific Achievement Award (Main Contributor)
2019: Chinese Academy of Sciences Annual Innovation Figure
2018: Zhongyuan Concord Life Medicine Innovation Breakthrough Award
2017: HHMI International Scholar
2013: Gordon Conference Scholarship
2012: ISSCR Scholarship
2011: ISSCR Best Poster Award
Research
Stem Cell Differentiation and Regeneration Nutritional and Metabolic Programming
A multi-tissue metabolome atlas of primate pregnancy, Yu D*, Wan H*, Tong C*, Guang L*, Chen G*, Su J*, Zhang L, Wang Y, Xiao Z, Zhai J, Yan L, Ma W, Liang K, Liu T, Wang Y, Peng Z, Luo L, Yu R, Li W#, Qi H#, Wang H#, Shyh-Chang N#, 2024
Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells, Yu X*, Wu H*, Su J*, Liu X, Liang K, Li Q, Yu R, Shao X, Wang H#, Wang YL#, Shyh-Chang N#, 2024
Lin28a maintains a subset of adult muscle stem cells in an embryonic-like state, Wang P, Liu X, Yao Z, Chen Y, Luo L, Liang K, Tan JE, Chua MJ, Chua YB, Ma S, Zhang L, Ma W, Liu S, Cao W, Guo L, Guang L, Wang Y, Zhao H, Ai N, Li Y, Li C, Wang RR, Teh BT, Jiang L, Yu K, Shyh-Chang N#, 2023
Pregnancy-induced metabolic reprogramming and regenerative responses to pro-aging stresses, Yu D, Luo L, Wang H#, Shyh-Chang N#, 2024
Construction of a cross-species cell landscape at single-cell level, Wang R, Zhang P#, Wang J, Ma L, E W, Suo S, Jiang M, Li J, Chen H, Sun H, Fei L, Zhou Z, Zhou Y, Chen Y, Zhang W, Wang X, Mei Y, Sun Z, Yu C, Shao J, Fu Y, Xiao Y, Ye F, Fang X, Wu H, Guo Q, Fang X, Li X, Gao X, Wang D, Xu PF, Zeng R, Xu G, Zhu L, Wang L, Qu J, Zhang D, Ouyang H, Huang H, Chen M, Shyh-Chang N#, Liu GH#, Yuan GC#, Guo G#, Han X#, 2023
Muscle injuries induce a prostacyclin-PPARγ/PGC1a-FAO spike that boosts regeneration, Luo L, Chua YB, Liu T, Liang K, Chua MJ, Ma W, Goh JW, Wang Y, Su J, Ho YS, Li CW, Liu KH, Teh BT, Yu K, Shyh-Chang N#, 2023
XAI-enabled neural network analysis of metabolite spatial distributions, Ma W, Luo L, Liang K, Liu T, Su J, Wang Y, Li J, Zhou SK, Shyh-Chang N#, 2023
Spatial metabolomics reveals skeletal myofiber subtypes, Luo L, Ma W, Liang K, Wang Y, Su J, Liu R, Liu T, Shyh-Chang N#, 2023
Stabilizing formative pluripotent states with germ cell competency, Shyh-Chang N＃ and Lei Li＃, 2021
Putting stem cells on a low-fat diet switches their pluripotent state, Jiang Z, Guang L, Li L, Shyh-Chang N#, 2019
SIRT2 and glycolytic enzyme acetylation in pluripotent stem cells, Liu TM, Shyh-Chang N#, 2017
Lin28 and let-7 in the metabolic physiology of aging, Jun-Hao ET, Gupta RR, Shyh-Chang, N#, 2016
Metabolic switches linked to pluripotency and embryonic stem cell differentiation, Shyh-Chang, N. and Daley, G. Q., 2015
Lin28 enhances tissue repair by reprogramming cellular metabolism, Shyh-Chang, N.*, Zhu, H.*, de Soysa, T. Y., Shinoda, G., Seligson, M. T., Tsanov, K. T., Nguyen L., Asara, J. M., Cantley, L. C., and Daley, G. Q., 2013
Lin28: Primal regulator of growth and metabolism in stem cells, Shyh-Chang, N. and Daley, G. Q., 2013
Influence of threonine metabolism on S-adenosylmethionine and histone methylation, Shyh-Chang, N., Locasale, J. W., Lyssiotis, C. A., Zheng, Y., Teo, R. Y., Ratanasirintrawoot, S., Zhang, J., Onder, T., Unternaehrer, J. J., Zhu, H., Asara, J. M., Daley, G. Q., and Cantley, L. C., 2012
Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis, Zhang, W. C., Shyh-Chang, N., Yang, H., Rai, A., Umashankar, S., Ma, S., Soh, B. S., Sun, L. L., Tai, B. C., Nga, M. E., Bhakoo, K. K., Jayapal, S. R., Nichane, M., Yu, Q., Ahmed, D. A., Tan, C., Sing, W. P., Tam, J., Thirugananam, A., Noghabi, M. S., Pang, Y. H., Ang, H. S., Mitchell, W., Robson, P., Kaldis, P., Soo, R. A., Swarup, S., Lim, E. H., and Lim, B., 2012
The Lin28/let-7 axis regulates glucose metabolism, Zhu, H.*, Shyh-Chang, N.*, Segre, A. V., Shinoda, G., Shah, S. P., Einhorn, W. S., Takeuchi, A., Engreitz, J. M., Hagan, J. P., Kharas, M. G., Urbach, A., Thornton, J. E., Triboulet, R., Gregory, R. I., DIAGRAM Consortium, MAGIC Investigators, Altshuler, D., and Daley GQ., 2011
Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies, Zhu, H., Shah, S., Shyh-Chang, N., Shinoda, G., Einhorn, W. S., Viswanathan, S. R., Takeuchi, A., Grasemann, C., Rinn, J. L., Lopez, M. F., Hirschhorn, J. N., Palmert, M. R., and Daley, G. Q., 2010
