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Tongbiao Zhao
tbzhao@ioz.ac.cn
English, Chinese
Beijing
Chinese Academy of Sciences
Institute of Zoology
  • 2004 - PhD: Institute of Zoology, Chinese Academy of Sciences
  • Achievement: Chief Scientist of National Key R&D Program
  • 2004-2006 - Postdoctoral Researcher: Institute of Biophysics, Chinese Academy of Sciences
  • 2007-2010 - Postdoctoral Researcher: University of California, San Diego
  • 2010 - Assistant Specialist III: University of California, San Diego
  • 2012-present - Researcher: Institute of Zoology, Chinese Academy of Sciences
Stem Cell Transplantation Immunology
Stem Cell Metabolism
Pluripotent Stem Cell Differentiation
  • Lin-PU.1dimGATA-1- defines haematopoietic stem cells with long-term multilineage reconstitution activity., Xu H, Tan S, Zhao Y, Zhang L, Cao W, Li X, Tian J, Wang X, Li X, Wang F, Cao J, Zhao T., 2023
  • A novel inducible haematopoietic cell-depleting mouse model for chimeric complementation of blood cells., Cao W, Cao J, Li X, Xu H, Tian J, Li X, Wang F, Zhao T., 2023
  • Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamine., Cao J, Li M, Liu K, Shi X, Sui N, Yao Y, Wang X, Li S, Tian Y, Tan S, Zhao Q, Wang L, Chai X, Zhang L, Liu C, Li X, Chang Z, Li D, Zhao T., 2023
  • Evaluating mitophagy in embryonic stem cells by using fluorescence-based imaging., Liu K, Li X, Li Z, Cao J, Li X, Xu Y, Liu L, Zhao T., 2022
  • BNIP3-dependent mitophagy safeguards ESC genomic integrity via preventing oxidative stress-induced DNA damage and protecting homologous recombination., Zhao Q, Liu K, Zhang L, Li Z, Wang L, Cao J, Xu Y, Zheng A, Chen Q, Zhao T., 2022
  • BNIP3(BCL2 interacting protein 3) regulates pluripotency by modulating mitochondrial homeostasis via mitophagy., Liu K, Zhao Q, Sun H, Liu L, Wang C, Li Z, Xu Y, Wang L, Zhang L, Zhang H, Chen Q, Zhao T., 2022
  • PINK1-mediated mitophagy maintains pluripotency through optineurin., Wang C, Liu K, Cao J, Wang L, Zhao Q, Li Z, Zhang H, Chen Q, Zhao T., 2021
  • Enhance anti-lung tumor efficacy of chimeric antigen receptor-T cells by ectopic expression of C–C motif chemokine receptor 6., Jin L, Cao L, Zhu Y, Cao J, Li X, Zhou J, Liu B, Zhao T., 2021
  • Chimeric antigen receptor T (CAR-T) cells expanded with IL-7/IL-15 mediate superior antitumor effects., Zhou J, Jin L, Wang F, Zhang Y, Liu B, Zhao T., 2019
  • USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5., Gu H, Shi X, Liu C, Wang C, Sui N, Zhao Y, Gong J, Wang F, Zhang H, Li W, Zhao T., 2019
  • Phosphorylation of ULK1 by AMPK is essential for mouse embryonic stem cell self-renewal and pluripotency., Gong J, Gu H, Zhao L, Wang L, Liu P, Wang F, Xu H, Zhao T., 2018
  • High autophagic flux guards ESC identity through coordinating autophagy machinery gene program by FOXO1., Liu P, Liu K, Gu H, Wang W, Gong J, Zhu Y, Zhao Q, Cao J, Han C, Gao F, Chen Q, Li W, Jiao J, Hu B, Zhou Q, Zhao T., 2017
  • PIM2 regulates stemness through phosphorylation of 4E-BP1., Sun H, Cao J, Zhao L, Zhu S, Chen S, Li Y, Zhao B, Zhao T., 2017
  • ATG3-dependent autophagy mediates mitochondrial homeostasis in pluripotency acquirement and maintenance., Liu K, Zhao Q, Liu P, Cao J, Gong J, Wang C, Wang W, Li X, Sun H, Zhang C, Li Y, Jiang M, Zhu S, Sun Q, Jiao J, Hu B, Zhao X, Li W, Chen Q, Zhou Q, Zhao T., 2016
  • p18 inhibits reprogramming through inactivation of Cdk4/6., Zhu S, Cao J, Sun H, Liu K, Li Y, Zhao T., 2016
  • Treatment of multiple sclerosis by transplantation of neural stem cells derived from induced pluripotent stem cells., Zhang C, Cao J, Li X, Xu H, Wang W, Wang L, Zhao X, Li W, Jiao J, Hu B, Zhou Q, Zhao T., 2016
  • Humanized mice reveal differential immunogenicity of cells derived from autologous induced pluripotent stem cells., Zhao T, Zhang Z, Westenskow P, Todorova D, Hu Z, Lin T, Rong Z, Kim J, He J, Wang M, Clegg D, Yang Y, Zhang K, Friedlander M, Xu Y., 2015
  • Immunogenicity and functional evaluation of iPSC-derived organs for transplantation., Wang L, Cao J, Wang Y, Lan T, Liu L, Wang W, Jin N, Gong J, Zhang C, Teng F, Yan G, Li C, Li J, Wan H, Hu B, Li W, Zhao X, Qi Z, Zhao T, Zhou Q., 2015
  • Immunogenicity of induced pluripotent stem cells., Zhao T, Zhang Z, Rong Z, Xu Y., 2011
  • Granzyme H induces apoptosis of target tumor cells characterized by DNA fragmentation and Bid-dependent mitochondrial damage., Hou Q, Zhao T, Zhang H, Lu H, Zhang Q, Sun L, Fan Z., 2008
  • Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death., Zhao T, Zhang H, Guo Y, Fan Z., 2007
  • Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells., Zhao T, Zhang H, Guo Y, Zhang Q, Hua G, Lu H, Hou Q, Liu H, Fan Z., 2007
Stem Cells Immunology Transplantation Metabolism Pluripotency Differentiation Ips Cells Autophagy Mitochondria Standardization

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