Professor | Yukai Wang | Asia Growth Partners

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Name	Yukai Wang
Contact Information	wangyukai@ioz.ac.cn
Language ability	Chinese, English
Province	Beijing

Upload Avatar (500 x 500)

Name

Yukai Wang

Contact Information

wangyukai@ioz.ac.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Chinese Academy of Sciences
Faculty	Institute of Zoology
Academic Background & Achievements	2011 - PhD: Shandong University Published over 30 papers in journals like Cell, Cell Reports Granted 3 patents Led the development of 2 stem cell community standards
Work Experience	2011-present - Chinese Academy of Sciences, Institute of Zoology - Postdoctoral Researcher, Assistant Researcher, Associate Researcher
Awards	2019: 'Top Ten Advances in Chinese Life Sciences' 22nd China International Hi-Tech Fair 'Outstanding Product Award' 2023 Zhongguancun Forum 'Top 100 New Technologies and Products'

University/Lab Affiliation and Title

Chinese Academy of Sciences

Faculty

Institute of Zoology

Academic Background & Achievements

2011 - PhD: Shandong University
Published over 30 papers in journals like Cell, Cell Reports
Granted 3 patents
Led the development of 2 stem cell community standards

Work Experience

2011-present - Chinese Academy of Sciences, Institute of Zoology - Postdoctoral Researcher, Assistant Researcher, Associate Researcher

Awards

2019: 'Top Ten Advances in Chinese Life Sciences'
22nd China International Hi-Tech Fair 'Outstanding Product Award'
2023 Zhongguancun Forum 'Top 100 New Technologies and Products'

Areas of Focus	Stem cell fate regulation and directed differentiation Human neural organoids for disease modeling and drug screening Development of neuronal cell-based medicines for major neurological diseases
Publications	One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation in vitro and survival after transplantation in vivo., Feng L, Li D, Tian Y, Zhao CS, Sun Y, Kou XL, Wu J, Wang L, Gu Q, Li W, Hao J, Hu BY, Wang YK, 2024 Safety and efficacy of human ESC-derived corneal endothelial cells for corneal endothelial dysfunction., Yu J, Yu NY, Tian Y, Fang YF, An B, Feng GH, Wu J, Wang L, Hao J, Wang LQ, Zhou Q, Li W, Wang YK, Hu BY, 2023 Human midbrain dopaminergic progenitors., Wang YK, Feng L, Ma AJ, Hao J, Zhang Y, Chen YJ, Chen ZG, Yu JY, Liu Y, Liu CM, Zhang Y, Wang CL, Teng ZQ, Zhou JQ, Li TQ, Wang L, Fu BQ, Fu Y, Zhu LJ, Liang LM, Cao JN, Wang L, Zhou Q, Xiang P, Hu BY, Zhao TB, 2023 Human neural stem cells., Wang YK, Yu J, Zhang TT, Ma AJ, Hao J, Chen YJ, Liu CM, Liu Y, Wang CL, Zhai PJ, Xiang P, Li TQ, Tang TS, Chen H, Bao XJ, Wang YL, He WY, Fan J, Teng ZQ, Wang L, Zhou JX, Fu BQ, Fu Y, Feng L, Cao JN, Liang LM, Wang L, Zhou Q, Zhang Y, Hu BY, Zhao TB, 2023 Single-cell transcriptomics reveals the cell fate transitions of human dopaminergic progenitors derived from hESCs., Liang LM, Tian Y, Feng L, Wang CQ, Feng GH, Stacey GN, Chang NS, Wu J, Hu BY, Li W, Hao J, Wang L, Wang YK, 2022 Human ESC-derived immunity- and matrix- regulatory cells ameliorated white matter damage and vascular cognitive impairment in rats subjected to chronic cerebral hypoperfusion., Zhao YL, Wu J, Li D, Liu J, Chen WQ, Hou ZR, Liu KL, Jiang LL, Chen XW, Wang L, Hu BY, Zong FR, Wang YK, Wang YL, 2022 Neuronal cell-based medicines from pluripotent stem cells: development, production, and pre-clinical assessment., Sun Y, Feng L, Liang LM, Stacey GN, Wang CQ, Wang YK, Hu BY, 2021 Infusion of hESC derived Immunity-and-matrix regulatory cells improves cognitive ability in early-stage AD mice., Liu J, Hou ZR, Wu J, Liu KL, Li D, Gao TT, Liu WJ, An B, Sun Y, Mo F, Wang L, Wang YK, Hao J, Hu BY, 2021 Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease., Wang YK, Zhu WW, Wu MH, Wu YH, Liu ZX, Liang LM, Sheng C, Hao J, Wang L, Li W, Zhou Q, Hu BY, 2018 Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos., Wang JQ, Wang LY, Feng GH, Wang YK, Li YF, Li X, Liu C, Jiao GY, Huang C, Shi JC, Zhou T, Chen Q, Liu ZH, Li W, Zhou Q, 2018 Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-wide Genetic Screening., He ZQ, Xia BL, Wang YK, Li J, Feng GH, Zhang LL, Li YH, Wan HF, Li TD, Xu K, Yuan XW, Li YF, Zhang XX, Zhang Y, Wang L, Li W, Zhou Q, 2017 Variations in mesenchymal-epithelial transition-related transcription factors during reprogramming of somatic cells from different germ layers into iPSCs., Lu XY, Wang YK, Yan L, Wang LB, Li W, Wang HM, 2016 Generation and Application of Mouse-Rat Allodiploid Embryonic Stem Cells., Li X, Cu XLi, Wang JQ, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W, Zhou Q, 2016 Generation of an LncRNA Gtl2-GFP Reporter for Rapid Assessment of Pluripotency in Mouse Induced Pluripotent Stem Cells., Li ZK, Wang LB, Wang YK, Liu L, Wang L, Li W, Zhou Q, 2015 Durable pluripotency and haploidy in epiblast stem cells derived from haploid embryonic stem cells in vitro., Shuai L, Wang YK, Dong MZ, Wang XP, Sang LS, Wang M, Wan HF, Luo GZ, Gu TT, Yuan Y, Feng CJ, Teng F, Li W, Liu XY, Li TD, Wang L, Wang XJ, Zhao XY, Zhou Q, 2015 Immunogenicity and functional evaluation of iPSC-derived organs for transplantation., Wang LB, Cao JN, Wang YK, Lan TS, Liu L, Wang WX, Jin N, Gong JQ, Zhang C, Teng F, Yan GL, Li C, Li JL, Wan HF, Hu BY, Li W, Zhao XY, Qi ZQ, Zhao TB, Zhou Q, 2015

Areas of Focus

Stem cell fate regulation and directed differentiation
Human neural organoids for disease modeling and drug screening
Development of neuronal cell-based medicines for major neurological diseases

Publications

One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation in vitro and survival after transplantation in vivo., Feng L, Li D, Tian Y, Zhao CS, Sun Y, Kou XL, Wu J, Wang L, Gu Q, Li W, Hao J, Hu BY, Wang YK, 2024
Safety and efficacy of human ESC-derived corneal endothelial cells for corneal endothelial dysfunction., Yu J, Yu NY, Tian Y, Fang YF, An B, Feng GH, Wu J, Wang L, Hao J, Wang LQ, Zhou Q, Li W, Wang YK, Hu BY, 2023
Human midbrain dopaminergic progenitors., Wang YK, Feng L, Ma AJ, Hao J, Zhang Y, Chen YJ, Chen ZG, Yu JY, Liu Y, Liu CM, Zhang Y, Wang CL, Teng ZQ, Zhou JQ, Li TQ, Wang L, Fu BQ, Fu Y, Zhu LJ, Liang LM, Cao JN, Wang L, Zhou Q, Xiang P, Hu BY, Zhao TB, 2023
Human neural stem cells., Wang YK, Yu J, Zhang TT, Ma AJ, Hao J, Chen YJ, Liu CM, Liu Y, Wang CL, Zhai PJ, Xiang P, Li TQ, Tang TS, Chen H, Bao XJ, Wang YL, He WY, Fan J, Teng ZQ, Wang L, Zhou JX, Fu BQ, Fu Y, Feng L, Cao JN, Liang LM, Wang L, Zhou Q, Zhang Y, Hu BY, Zhao TB, 2023
Single-cell transcriptomics reveals the cell fate transitions of human dopaminergic progenitors derived from hESCs., Liang LM, Tian Y, Feng L, Wang CQ, Feng GH, Stacey GN, Chang NS, Wu J, Hu BY, Li W, Hao J, Wang L, Wang YK, 2022
Human ESC-derived immunity- and matrix- regulatory cells ameliorated white matter damage and vascular cognitive impairment in rats subjected to chronic cerebral hypoperfusion., Zhao YL, Wu J, Li D, Liu J, Chen WQ, Hou ZR, Liu KL, Jiang LL, Chen XW, Wang L, Hu BY, Zong FR, Wang YK, Wang YL, 2022
Neuronal cell-based medicines from pluripotent stem cells: development, production, and pre-clinical assessment., Sun Y, Feng L, Liang LM, Stacey GN, Wang CQ, Wang YK, Hu BY, 2021
Infusion of hESC derived Immunity-and-matrix regulatory cells improves cognitive ability in early-stage AD mice., Liu J, Hou ZR, Wu J, Liu KL, Li D, Gao TT, Liu WJ, An B, Sun Y, Mo F, Wang L, Wang YK, Hao J, Hu BY, 2021
Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease., Wang YK, Zhu WW, Wu MH, Wu YH, Liu ZX, Liang LM, Sheng C, Hao J, Wang L, Li W, Zhou Q, Hu BY, 2018
Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos., Wang JQ, Wang LY, Feng GH, Wang YK, Li YF, Li X, Liu C, Jiao GY, Huang C, Shi JC, Zhou T, Chen Q, Liu ZH, Li W, Zhou Q, 2018
Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-wide Genetic Screening., He ZQ, Xia BL, Wang YK, Li J, Feng GH, Zhang LL, Li YH, Wan HF, Li TD, Xu K, Yuan XW, Li YF, Zhang XX, Zhang Y, Wang L, Li W, Zhou Q, 2017
Variations in mesenchymal-epithelial transition-related transcription factors during reprogramming of somatic cells from different germ layers into iPSCs., Lu XY, Wang YK, Yan L, Wang LB, Li W, Wang HM, 2016
Generation and Application of Mouse-Rat Allodiploid Embryonic Stem Cells., Li X, Cu XLi, Wang JQ, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W, Zhou Q, 2016
Generation of an LncRNA Gtl2-GFP Reporter for Rapid Assessment of Pluripotency in Mouse Induced Pluripotent Stem Cells., Li ZK, Wang LB, Wang YK, Liu L, Wang L, Li W, Zhou Q, 2015
Durable pluripotency and haploidy in epiblast stem cells derived from haploid embryonic stem cells in vitro., Shuai L, Wang YK, Dong MZ, Wang XP, Sang LS, Wang M, Wan HF, Luo GZ, Gu TT, Yuan Y, Feng CJ, Teng F, Li W, Liu XY, Li TD, Wang L, Wang XJ, Zhao XY, Zhou Q, 2015
Immunogenicity and functional evaluation of iPSC-derived organs for transplantation., Wang LB, Cao JN, Wang YK, Lan TS, Liu L, Wang WX, Jin N, Gong JQ, Zhang C, Teng F, Yan GL, Li C, Li JL, Wan HF, Hu BY, Li W, Zhao XY, Qi ZQ, Zhao TB, Zhou Q, 2015

Stem Cells Neurobiology Differentiation Organoids Disease Modeling Drug Screening Neuronal Cells Neurological Diseases Therapy Regenerative Medicine

Jingtao Guo - Chinese Academy of Sciences

Shi-Qiang Huang - Chinese Academy of Sciences

Liu Yixun - Chinese Academy of Sciences

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