Professor | Hongbiao Huang | Asia Growth Partners

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Name	Hongbiao Huang
Contact Information	huanghongbiao@gzhmu.edu.cn
Language ability	Chinese, English
Province	Guangdong

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Name

Hongbiao Huang

Contact Information

huanghongbiao@gzhmu.edu.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	Guangzhou Medical University
Faculty	Basic Medical Sciences
Academic Background & Achievements	PhD: Not mentioned Guangdong Province 'Special Support Plan' Young Top Talent Guangdong Province Outstanding Young Teacher Cultivation Object Guangzhou High-Level Talent
Awards	Guangdong Province 'Special Support Plan' Young Top Talent Guangdong Province Outstanding Young Teacher Cultivation Object Ministry of Education University Outstanding Scientific Achievement Award in Natural Science Second Prize (2021): Proteasome Function Regulation in Tumors Chinese Medical Association Science and Technology Progress Third Prize (2017): Proteasome Function Regulation Guangzhou Science and Technology Progress First Prize (2016): Proteasome Function Regulation

University/Lab Affiliation and Title

Guangzhou Medical University

Faculty

Basic Medical Sciences

Academic Background & Achievements

PhD: Not mentioned
Guangdong Province 'Special Support Plan' Young Top Talent
Guangdong Province Outstanding Young Teacher Cultivation Object
Guangzhou High-Level Talent

Awards

Guangdong Province 'Special Support Plan' Young Top Talent
Guangdong Province Outstanding Young Teacher Cultivation Object
Ministry of Education University Outstanding Scientific Achievement Award in Natural Science Second Prize (2021): Proteasome Function Regulation in Tumors
Chinese Medical Association Science and Technology Progress Third Prize (2017): Proteasome Function Regulation
Guangzhou Science and Technology Progress First Prize (2016): Proteasome Function Regulation

Areas of Focus	Protein Modification and Tumor
Publications	HSP90β Impedes STUB1-Induced Ubiquitination of YTHDF2 to Drive Sorafenib Resistance in Hepatocellular Carcinoma, Liao Y, Liu Y, Yu C, Lei Q, Cheng J, Kong W, Yu Y, Zhuang X, Sun W, Yin S, Cai G, Huang H, 2023 Neddylation of HER2 Inhibits its Protein Degradation and promotes Breast Cancer Progression, Xiaohong Xia, Tumei Hu, Xiaoyue He, Yuan Liu, Cuifu Yu, Weiyao Kong, Yuning Liao, Daolin Tang, Jinbao Liu, Hongbiao Huang, 2023 SNS-023 sensitizes hepatocellular carcinoma to sorafenib by inducing degradation of cancer drivers SIX1 and RPS16, Yuan Liu, Weiyao Kong, Cuifu Yu, Zhenlong Shao, Qiucheng Lei, Yuanfei Deng, Gengxi Cai, Xuefen Zhuang, Wenshuang Sun, Shigang Wu, Rong Wang, Xiang Chen, Guoxing Chen, Hongbiao Huang, Yuning Liao, 2023 A SIX1 degradation inducer blocks excessive proliferation of prostate cancer, Yuning Liao, Wenshuang Sun, Zhenlong Shao, Yuan Liu, Xiaoyu Zhong, Yuanfei Deng, Fang Liu, Hongbiao Huang, Jinbao Liu, 2022 A new role of GRP75-USP1-SIX1 protein complex in driving prostate cancer progression and castration resistance, Liao Y, Liu Y, Shao Z, Xia X, Deng Y, Cai J, Yao L, He J, Yu C, Hu T, Sun W, Liu F, Tang D, Liu J, Huang H, 2021 USP1-dependent RPS16 protein stability drives growth and metastasis of human hepatocellular carcinoma cells, Liao Y, Shao Z, Liu Y, Xia X, Deng Y, Yu C, Sun W, Kong W, He X, Liu F, Guo Z, Chen G, Tang D, Gan H, Liu J, Huang H, 2021 Selective degradation of AR-V7 to overcome castration resistance of prostate cancer, Liao Y, Yu C, Shao Z, Xia X, Hu T, Kong W, He X, Sun W, Deng Y, Liao Y, Huang H, 2021 The deubiquitinating enzyme USP15 stabilizes ERα and promotes breast cancer progression, Xia X, Huang C, Liao Y, Liu Y, He J, Shao Z, Hu T, Yu C, Jiang L, Liu J, Huang H, 2021 Targeting GRP78-dependent AR-V7 protein degradation overcomes castration-resistance in prostate cancer therapy, Liao Y, Liu Y, Xia X, Shao Z, Huang C, He J, Jiang L, Tang D, Liu J, Huang H, 2020 Deubiquitination and stabilization of estrogen receptor α by ubiquitin-specific protease 7 promotes breast tumorigenesis, Xia X, Liao Y, Huang C, Liu Y, He J, Shao Z, Jiang L, Dou QP, Liu J, Huang H, 2019 Inhibition of USP14 enhances the sensitivity of breast cancer to enzalutamide, Xia X, Huang C, Liao Y, Liu Y, He J, Guo Z, Jiang L, Wang X, Liu J, Huang H, 2019 Inhibition of EGFR signaling with Spautin-1 represents a novel therapeutics for prostate cancer, Liao Y, Guo Z, Xia X, Liu Y, Huang C, Jiang L, Wang X, Liu J, Huang H, 2019 USP10 Modulates the SKP2/Bcr-Abl axis via Stabilizing SKP2 in Chronic Myeloid Leukemia, Liao Y, Liu N, Xia X, Guo Z, Li Y, Jiang L, Zhou R, Tang D, Huang H, Liu J, 2019 Growth arrest and apoptosis induction in androgen receptor-positive human breast cancer cells by inhibition of USP14-mediated androgen receptor deubiquitination, Liao Y, Xia X, Liu N, Cai J, Guo Z, Li Y, Jiang L, Dou Q, Tang D, Huang H, Liu J, 2018 Targeting proteasome associated deubiquitinases as a novel strategy for the treatment of estrogen receptor positive breast cancer, Xia X, Liao Y, Guo Z, Li Y, Jiang L, Zhang F, Huang C, Liu Y, Wang X, Liu N, Liu J, Huang H, 2018

Areas of Focus

Protein Modification and Tumor

Publications

HSP90β Impedes STUB1-Induced Ubiquitination of YTHDF2 to Drive Sorafenib Resistance in Hepatocellular Carcinoma, Liao Y, Liu Y, Yu C, Lei Q, Cheng J, Kong W, Yu Y, Zhuang X, Sun W, Yin S, Cai G, Huang H, 2023
Neddylation of HER2 Inhibits its Protein Degradation and promotes Breast Cancer Progression, Xiaohong Xia, Tumei Hu, Xiaoyue He, Yuan Liu, Cuifu Yu, Weiyao Kong, Yuning Liao, Daolin Tang, Jinbao Liu, Hongbiao Huang, 2023
SNS-023 sensitizes hepatocellular carcinoma to sorafenib by inducing degradation of cancer drivers SIX1 and RPS16, Yuan Liu, Weiyao Kong, Cuifu Yu, Zhenlong Shao, Qiucheng Lei, Yuanfei Deng, Gengxi Cai, Xuefen Zhuang, Wenshuang Sun, Shigang Wu, Rong Wang, Xiang Chen, Guoxing Chen, Hongbiao Huang, Yuning Liao, 2023
A SIX1 degradation inducer blocks excessive proliferation of prostate cancer, Yuning Liao, Wenshuang Sun, Zhenlong Shao, Yuan Liu, Xiaoyu Zhong, Yuanfei Deng, Fang Liu, Hongbiao Huang, Jinbao Liu, 2022
A new role of GRP75-USP1-SIX1 protein complex in driving prostate cancer progression and castration resistance, Liao Y, Liu Y, Shao Z, Xia X, Deng Y, Cai J, Yao L, He J, Yu C, Hu T, Sun W, Liu F, Tang D, Liu J, Huang H, 2021
USP1-dependent RPS16 protein stability drives growth and metastasis of human hepatocellular carcinoma cells, Liao Y, Shao Z, Liu Y, Xia X, Deng Y, Yu C, Sun W, Kong W, He X, Liu F, Guo Z, Chen G, Tang D, Gan H, Liu J, Huang H, 2021
Selective degradation of AR-V7 to overcome castration resistance of prostate cancer, Liao Y, Yu C, Shao Z, Xia X, Hu T, Kong W, He X, Sun W, Deng Y, Liao Y, Huang H, 2021
The deubiquitinating enzyme USP15 stabilizes ERα and promotes breast cancer progression, Xia X, Huang C, Liao Y, Liu Y, He J, Shao Z, Hu T, Yu C, Jiang L, Liu J, Huang H, 2021
Targeting GRP78-dependent AR-V7 protein degradation overcomes castration-resistance in prostate cancer therapy, Liao Y, Liu Y, Xia X, Shao Z, Huang C, He J, Jiang L, Tang D, Liu J, Huang H, 2020
Deubiquitination and stabilization of estrogen receptor α by ubiquitin-specific protease 7 promotes breast tumorigenesis, Xia X, Liao Y, Huang C, Liu Y, He J, Shao Z, Jiang L, Dou QP, Liu J, Huang H, 2019
Inhibition of USP14 enhances the sensitivity of breast cancer to enzalutamide, Xia X, Huang C, Liao Y, Liu Y, He J, Guo Z, Jiang L, Wang X, Liu J, Huang H, 2019
Inhibition of EGFR signaling with Spautin-1 represents a novel therapeutics for prostate cancer, Liao Y, Guo Z, Xia X, Liu Y, Huang C, Jiang L, Wang X, Liu J, Huang H, 2019
USP10 Modulates the SKP2/Bcr-Abl axis via Stabilizing SKP2 in Chronic Myeloid Leukemia, Liao Y, Liu N, Xia X, Guo Z, Li Y, Jiang L, Zhou R, Tang D, Huang H, Liu J, 2019
Growth arrest and apoptosis induction in androgen receptor-positive human breast cancer cells by inhibition of USP14-mediated androgen receptor deubiquitination, Liao Y, Xia X, Liu N, Cai J, Guo Z, Li Y, Jiang L, Dou Q, Tang D, Huang H, Liu J, 2018
Targeting proteasome associated deubiquitinases as a novel strategy for the treatment of estrogen receptor positive breast cancer, Xia X, Liao Y, Guo Z, Li Y, Jiang L, Zhang F, Huang C, Liu Y, Wang X, Liu N, Liu J, Huang H, 2018

Protein Modification Tumor Post-Translational Modification Cancer Mechanism Proteasome Ubiquitination Deubiquitination Cancer Resistance Protein Degradation Oncology

Xiaofan Wei - Peking University

Zhang Bo - Peking University

Tan Xinti - Wuhan University

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