Professor | Wei Li | Asia Growth Partners

	Upload Avatar (500 x 500)
Name	Wei Li
Contact Information	leways@gwcmc.org
Language ability	Chinese, English
Province	Guangdong

Upload Avatar (500 x 500)

Name

Wei Li

Contact Information

leways@gwcmc.org

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	Guangzhou Medical University
Faculty	Basic Medical Sciences
Academic Background & Achievements	1998-2003 Bachelor's and Doctorate: Lanzhou University National Outstanding Youth Fund recipient Selected as a leading talent in scientific and technological innovation by the Ministry of Science and Technology
Work Experience	2003-2009 - Tsinghua University and NIH NIDDK - Postdoctoral Research 2009-present - Guangzhou Women and Children's Medical Center - Head of Institute of Reproductive and Perinatal Research
Awards	Second Prize of Science and Technology Progress Award by Ministry of Education First Prize of Natural Science by Maternal and Child Health Research Association

University/Lab Affiliation and Title

Guangzhou Medical University

Faculty

Basic Medical Sciences

Academic Background & Achievements

1998-2003 Bachelor's and Doctorate: Lanzhou University
National Outstanding Youth Fund recipient
Selected as a leading talent in scientific and technological innovation by the Ministry of Science and Technology

Work Experience

2003-2009 - Tsinghua University and NIH NIDDK - Postdoctoral Research
2009-present - Guangzhou Women and Children's Medical Center - Head of Institute of Reproductive and Perinatal Research

Awards

Second Prize of Science and Technology Progress Award by Ministry of Education
First Prize of Natural Science by Maternal and Child Health Research Association

Areas of Focus	Post-translational modification regulation in gametogenesis, especially meiosis Role and mechanism of histone modification in gametogenesis and stem cell maintenance and differentiation Molecular basis of reproductive aging-related diseases New methods and pathways for fertility maintenance and remodeling
Publications	Slx5p-Slx8p promotes accurate chromosome segregation by mediating the degradation of synaptonemal complex components during meiosis., Liu C, Zhao HC, Xiao S, Han T, Chen Y, Wang T, Ma Y, Gao H, Xie Z, Du L, Li J, Li G, Li W, 2020 Essential role of autophagy in resource allocation during sexual reproduction., Gao H, Khawar MB, Li W, 2020 FBXO47 regulates telomere-inner nuclear envelope integration by stabilizing TRF2 during meiosis., Hua R, Wei H, Liu C, Zhang Y, Liu S, Guo Y, Cui Y, Zhang X, Guo X, Li W, Liu M, 2019 USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5., Gu H, Shi X, Liu C, Wang C, Sui N, Zhao Y, Gong J, Wang F, Zhang H, Li W, Zhao T, 2019 Mutations in PMFBP1 Cause Acephalic Spermatozoa Syndrome., Zhu F, Liu C, Wang F, Yang X, Zhang J, Wu H, Zhang Z, He X, Zhang Z, Zhou P, Wei Z, Shang Y, Wang L, Zhang R, Ouyang YC, Sun QY, Cao Y, Li W, 2018 Autophagy regulates testosterone synthesis by facilitating cholesterol uptake in the Leydig cells., Gao F, Li G, Liu C, Gao H, Wang H, Liu W, Chen M, Shang Y, Wang L, Shi J, Xia W, Jiao J, Gao F, Li J, Chen L, Li W, 2018 Dual roles of TRF1 in tethering telomeres to the nuclear envelope and protecting them from fusion during meiosis., Wang L, Tu Z, Liu C, Liu H, Kaldis P, Chen Z, Li W, 2018 Essential role for SUN5 in anchoring sperm head to the tail., Shang Y, Zhu F, Wang L, Ouyang YC, Dong MZ, Liu C, Zhao H, Cui X, Ma D, Zhang Z, Yang X, Guo Y, Liu F, Yuan L, Gao F, Guo X, Sun QY, Cao Y, Li W, 2017 Ufd2p synthesizes branched ubiquitin chains to promote the degradation of proteins modified with atypical ubiquitin chains., Liu C, Liu W, Ye Y, Li W, 2017 The E3 ubiquitin ligase RNF114 and TAB1 degradation are required for maternal-to-zygotic transition., Yang Y, Zhou C, Wang Y, Liu W, Liu C, Wang L, Liu Y, Shang Y, Li M, Zhou S, Wang Y, Zeng W, Zhou J, Huo R, Li W, 2017 Sirt1 regulates acrosome biogenesis by modulating autophagic flux during spermiogenesis in mice., Liu C, Song Z, Wang L, Yu H, Liu W, Shang Y, Xu Z, Zhao H, Gao F, Wen J, Zhao L, Gui Y, Jiao J, Gao F, Li W, 2017 H2B ubiquitination regulates meiotic recombination by promoting chromatin relaxation., Xu Z, Song Z, Li G, Tu H, Liu W, Liu Y, Wang P, Wang Y, Cui X, Liu C, Shang Y, de Rooij DG, Gao F, Li W, 2016 Autophagy regulates spermatid differentiation via degradation of PDLIM1., Shang YL, Wang HN, Jia PF, Zhao HC, Liu C, Liu WX, Song ZH, Xu ZL, Yang L, Wang YF, Li W, 2016 Distinct temporal requirements for autophagy and proteasome in yeast meiosis., Wen FP, Guo YS, Hu Y, Wang YT, Wang Q, Yu HY, Tang CM, Yang J, Zhou T, Sha JH, Guo XJ, Li W, 2016 Autophagy is required for ectoplasmic specialization assembly in Sertoli cells., Liu C, Wang HN, Shang YL, Liu WX, Song ZH, Zhao HC, Wang LN, Jia PF, Gao FY, Xu ZL, Yang L, Gao F, Li W, 2016 Atg7 is required for acrosome biogenesis during spermatogenesis in mice., Wang HN, Wan HF, Li XX, Liu WX, Chen Q, Wang YQ, Yang L, Duan EK, Tang HM, Zhang XJ, Zhao XY, Gao F, Li W, 2014 Structural insights into the TRIM family of ubiquitin E3 ligases., Li Y, Wu H, Wu W, Zhuo W, Liu W, Zhang Y, Cheng M, Chen YG, Gao N, Yu H, Wang L, Li W, Yang M, 2014 Dimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48-linked ubiquitin chains., Liu WX, Shang YL, Zeng Y, Liu C, Li YC, Zhai LH, Wang P, Lou JZ, Xu P, Ye Y, Li W, 2014 Mechanism of ubiquitin chain assembly on the active site cysteine of the ubiquitin conjugating enzyme Ube2g2., Li W, Tu D, Li LY, Wollert T, Ghirlando R, Brunger AT, Ye Y, 2009 An ubiquitin ligase transfers preformed polyqubiquitin chains from a conjugating enzyme to substrate., Li W, Tu D, Brunger A, Ye Y, 2007

Areas of Focus

Post-translational modification regulation in gametogenesis, especially meiosis
Role and mechanism of histone modification in gametogenesis and stem cell maintenance and differentiation
Molecular basis of reproductive aging-related diseases
New methods and pathways for fertility maintenance and remodeling

Publications

Slx5p-Slx8p promotes accurate chromosome segregation by mediating the degradation of synaptonemal complex components during meiosis., Liu C, Zhao HC, Xiao S, Han T, Chen Y, Wang T, Ma Y, Gao H, Xie Z, Du L, Li J, Li G, Li W, 2020
Essential role of autophagy in resource allocation during sexual reproduction., Gao H, Khawar MB, Li W, 2020
FBXO47 regulates telomere-inner nuclear envelope integration by stabilizing TRF2 during meiosis., Hua R, Wei H, Liu C, Zhang Y, Liu S, Guo Y, Cui Y, Zhang X, Guo X, Li W, Liu M, 2019
USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5., Gu H, Shi X, Liu C, Wang C, Sui N, Zhao Y, Gong J, Wang F, Zhang H, Li W, Zhao T, 2019
Mutations in PMFBP1 Cause Acephalic Spermatozoa Syndrome., Zhu F, Liu C, Wang F, Yang X, Zhang J, Wu H, Zhang Z, He X, Zhang Z, Zhou P, Wei Z, Shang Y, Wang L, Zhang R, Ouyang YC, Sun QY, Cao Y, Li W, 2018
Autophagy regulates testosterone synthesis by facilitating cholesterol uptake in the Leydig cells., Gao F, Li G, Liu C, Gao H, Wang H, Liu W, Chen M, Shang Y, Wang L, Shi J, Xia W, Jiao J, Gao F, Li J, Chen L, Li W, 2018
Dual roles of TRF1 in tethering telomeres to the nuclear envelope and protecting them from fusion during meiosis., Wang L, Tu Z, Liu C, Liu H, Kaldis P, Chen Z, Li W, 2018
Essential role for SUN5 in anchoring sperm head to the tail., Shang Y, Zhu F, Wang L, Ouyang YC, Dong MZ, Liu C, Zhao H, Cui X, Ma D, Zhang Z, Yang X, Guo Y, Liu F, Yuan L, Gao F, Guo X, Sun QY, Cao Y, Li W, 2017
Ufd2p synthesizes branched ubiquitin chains to promote the degradation of proteins modified with atypical ubiquitin chains., Liu C, Liu W, Ye Y, Li W, 2017
The E3 ubiquitin ligase RNF114 and TAB1 degradation are required for maternal-to-zygotic transition., Yang Y, Zhou C, Wang Y, Liu W, Liu C, Wang L, Liu Y, Shang Y, Li M, Zhou S, Wang Y, Zeng W, Zhou J, Huo R, Li W, 2017
Sirt1 regulates acrosome biogenesis by modulating autophagic flux during spermiogenesis in mice., Liu C, Song Z, Wang L, Yu H, Liu W, Shang Y, Xu Z, Zhao H, Gao F, Wen J, Zhao L, Gui Y, Jiao J, Gao F, Li W, 2017
H2B ubiquitination regulates meiotic recombination by promoting chromatin relaxation., Xu Z, Song Z, Li G, Tu H, Liu W, Liu Y, Wang P, Wang Y, Cui X, Liu C, Shang Y, de Rooij DG, Gao F, Li W, 2016
Autophagy regulates spermatid differentiation via degradation of PDLIM1., Shang YL, Wang HN, Jia PF, Zhao HC, Liu C, Liu WX, Song ZH, Xu ZL, Yang L, Wang YF, Li W, 2016
Distinct temporal requirements for autophagy and proteasome in yeast meiosis., Wen FP, Guo YS, Hu Y, Wang YT, Wang Q, Yu HY, Tang CM, Yang J, Zhou T, Sha JH, Guo XJ, Li W, 2016
Autophagy is required for ectoplasmic specialization assembly in Sertoli cells., Liu C, Wang HN, Shang YL, Liu WX, Song ZH, Zhao HC, Wang LN, Jia PF, Gao FY, Xu ZL, Yang L, Gao F, Li W, 2016
Atg7 is required for acrosome biogenesis during spermatogenesis in mice., Wang HN, Wan HF, Li XX, Liu WX, Chen Q, Wang YQ, Yang L, Duan EK, Tang HM, Zhang XJ, Zhao XY, Gao F, Li W, 2014
Structural insights into the TRIM family of ubiquitin E3 ligases., Li Y, Wu H, Wu W, Zhuo W, Liu W, Zhang Y, Cheng M, Chen YG, Gao N, Yu H, Wang L, Li W, Yang M, 2014
Dimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48-linked ubiquitin chains., Liu WX, Shang YL, Zeng Y, Liu C, Li YC, Zhai LH, Wang P, Lou JZ, Xu P, Ye Y, Li W, 2014
Mechanism of ubiquitin chain assembly on the active site cysteine of the ubiquitin conjugating enzyme Ube2g2., Li W, Tu D, Li LY, Wollert T, Ghirlando R, Brunger AT, Ye Y, 2009
An ubiquitin ligase transfers preformed polyqubiquitin chains from a conjugating enzyme to substrate., Li W, Tu D, Brunger A, Ye Y, 2007

Gametogenesis Meiosis Post-Translational Modification Histone Modification Stem Cell Differentiation Reproductive Aging Fertility Remodeling Molecular Basis

Jiahao Sha - Nanjing Medical University

Xuefei Gao - Southern Medical University

Qinghua Shi - University of Science and Technology of China

View All

Personal Information

Academic Information

Research

Contact us

No account yet?

Personal Information

Academic Information

Research

Contact us