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Xing Guo
Basic Medical Sciences
Nanjing Medical University
Jiangsu
Language: English, Chinese
Neurodegeneration
Molecular Mechanisms
Intervention
Mitochondrial Quality Control
Huntington'S Disease
Neurobiology
Genetics
Stem Cells
Neuroscience
Clinical Applications
Areas of Focus
- Molecular mechanisms of neurodegenerative diseases and their intervention
Work Experience
- 2011.09-2016.10 - Case Western Reserve University - Postdoctoral Researcher
- 2016.10-2017.10 - Cleveland Clinic - Research Assistant
- 2017.10-present - Nanjing Medical University - Professor in the Department of Neurobiology
Academic Background & Achievements
- 2008.09-2011.07 PhD in Genetics: Peking Union Medical College
- National Excellent Young Scientist Fund recipient
- Jiangsu Province Distinguished Professor
Publications
- Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington’s disease., Liu CY, Fu ZX, Wu SS, Wang XS, Zhang SR, Chu C, Hong Y, Wu WB, Chen SQ, Jiang YQ, Wu Y, Song YB, Liu Y, Guo X., 2022
- Depressive patient-derived GABA interneurons reveal abnormal neural activity associated with HTR2C., Lu KQ, Hong Y, Tao MD, Shen LP, Zheng ZL, Fang KH, Yuan F, Xu M, Wang C, Zhu DY, Guo X, Liu Y., 2022
- Dysfunction of vesicular storage in young-onset Parkinson’s patient-derived dopaminergic neurons and organoids revealed by single cell electrochemical cytometry., Zhu WY, Tao MD, Hong Y, Wu SS, Chu C, Zheng ZL, Han X, Zhu Q, Xu M, Ewing AG, Guo X, Liu Y., 2022
- Human organoids in basic research and clinical applications., Tang XY, Wu SS, Wang D, Chu C, Hong Y, Tao MD, Hu H, Xu M, Guo X, Liu Y., 2022
- DSCAM/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome., Tang XY, Xu L, Wang J, Hong Y, Wang Y, Zhu Q, Wang D, Zhang XY, Liu CY, Fang KH, Han X, Wang S, Wang X, Xu M, Bhattacharyya A, Guo X, Lin M, Liu Y., 2021
- Abnormal mitochondria in Down syndrome iPSC-derived GABAergic interneurons and organoids., Xu L, Huo HQ, Lu KQ, Tang XY, Hong Y, Han X, Fu ZX, Fang KH, Xu M, Guo X, Liu Y., 2022
- Mutant huntingtin inhibits the mitochondrial unfolded protein response by impairing ABCB10 mRNA stability., Fu ZX, Liu F, Liu CY, Jin BF, Jiang YQ, Tang ML, Qi X, Guo X., 2019
- Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration., Guo X, Disatnik MH, Monbureau M, Shamloo M, Mochly-Rosen D, Qi X., 2013
- VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease., Guo X, Sun X, Hu D, Wang YJ, Fujioka H, Vyas R, Chakrapani S, Joshi AU, Luo Y, Mochly-Rosen D, Qi X., 2016
Awards
- 2013: Beijing Science and Technology Award
