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Yuguang Shi
Basic Medical Sciences
Nanjing Medical University
Jiangsu
Language: Chinese, English
Mitochondria
Aging
Molecular Mechanisms
Cardiolipin
Metabolism
Chronic Diseases
Neurodegenerative Diseases
Cancer
Lipid Metabolism
Heart Failure
Areas of Focus
- Molecular mechanisms of mitochondrial dysfunction and aging-related diseases
Work Experience
- 1991-1995 - University of California, San Francisco - Postdoctoral Researcher
- 1995-2006 - Eli Lilly and Company - Chief Scientist
- 2006-2014 - Pennsylvania State University - Tenured Professor
- 2014-present - Nanjing Medical University - Professor
Academic Background & Achievements
- 1977-1982 Bachelor's in Animal Science: Northwest A&F University
- 1983-1986 Master's in Genetics: University of New England, Australia
- 1986-1991 PhD in Molecular Biology: Australian National University
- Cloned new genes related to familial diabetes and other conditions
- Published over 60 articles with a cumulative impact factor over 400
Publications
- Cardiolipin remodeling by ALCAT1 links mitochondrial dysfunction to Parkinson's diseases., Song C, Zhang J, Qi S, Liu Z, Zhang X, Zheng Y, Andersen JP, Zhang W, Strong R, Martinez PA, Musi N, Nie J*, Shi Y*., 2019
- Defective Phosphatidylglycerol Remodeling Causes Hepatopathy, Linking Mitochondrial Dysfunction to Hepatosteatosis., Zhang X, Zhang J, Sun H, Liu X, Zheng Y, Xu D, Wang J, Jia D, Han X, Liu F, Nie J, Shi Y*., 2019
- SAD-A Promotes Glucose-Stimulated Insulin Secretion Through Phosphorylation and Inhibition of GDIα in Male Islet β Cells., Jia Nie, Chao Sun, Chang Z, Nicolas Musi, Yuguang Shi*., 2018
- Regulation of autophagy by mitochondrial phospholipids in health and diseases., Paul Hsua, Yuguang Shi*., 2017
- ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis., Li Wang, Xiaolei Liu, Jia Nie, Jun Zhang, Scot R. Kimball, Hai Zhang, Weiping J. Zhang, Leonard S. Jefferson, Zeneng Cheng, Qiuhe Ji*, Yuguang Shi*., 2015
- Cardiolipin remodeling by TAZ/tafazzin is selectively required for the initiation of mitophagy., Hsu P, Liu X, Zhang J, Wang HG, Ye JM, Shi Y*., 2015
- Modulators of Acyl-CoA Lysocardiolipin Acyltransferase 1 (ALCAT1) and Uses Thereof, Yuguang Shi, 2015
Awards
- 1993: Postdoctoral Fellowship from the Juvenile Diabetes Research Foundation International
- 1995: Postdoctoral Fellowship from the National Institutes of Health and American Cancer Society
- 1997: Outstanding Team Award from Eli Lilly and Company
- 2004: Outstanding Research Award from Eli Lilly and Company
- 2012: Innovation Award from Pennsylvania State University
- 2016: Second Prize in Science and Technology from Jiangsu Province
