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Zhenyi Su
Basic Medical Sciences
Nanjing Medical University
Jiangsu
Language: English, Chinese
Apoptosis
Necroptosis
Ferroptosis
Cancer
Metabolism
Metastasis
Cell Death
Tumor
Iron
Therapy
Areas of Focus
- Cell Death
- Tumor Metabolism
- Tumor Metastasis
Work Experience
- 2024-present - Nanjing Medical University, School of Basic Medical Sciences - Professor
- 2022-2024 - Columbia University, Institute for Cancer Genetics - Associate Research Scientist
- 2018-2022 - Columbia University, Institute for Cancer Genetics - Postdoctoral Researcher
- 2014-2016 - Harvard Medical School, Department of Cell Biology - Visiting Scholar
- 2012-2018 - Southeast University, School of Medicine - Lecturer
Academic Background & Achievements
- 2007-2012 PhD: Beijing Normal University, College of Life Sciences
- Research published in top journals like Nature Cancer, NCB, Cell Death and Differentiation, Genes & Development
Publications
- Specific regulation of BACH1 by the hot-spot mutant p53R175H reveals a distinct gain of function mechanism., Su, Z., Kon, N., Yi, J., Zhao, H., Zhang, W., Tang, Q., Li, H., …and Gu, W., 2023
- ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner., Su, Z., Dziedzic, S. A., Hu, D., Barrett, V. J., Broekema, N., Li, W., ... & Yuan, J., 2019
- ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease., Song, S.#, Su, Z.#, Kon, N., Chu, B., Li, H., Jiang, X., ... & Gu, W., 2023
- ABIN-1 is a key regulator in RIPK1-dependent apoptosis (RDA) and necroptosis, and ABIN-1 deficiency potentiates necroptosis-based cancer therapy in colorectal cancer., Cai, J., Hu, D., Sakya, J., Sun, T., Wang, D., Wang, L., Mao, X., and Su, Z.*, 2021
- ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC., Dziedzic, S., Su, Z., Barrett, V., Najafov, A., Mookhtiar, A., Amin, P., ... and Yuan, J., 2018
- Fluvastatin prevents lung adenocarcinoma bone metastasis by triggering autophagy., Yang, Z.#*, Su, Z.#*, DeWitt, J.1, Xie, L., Chen, Y., Li, X., Li, D., Xia, J., Zhang, Y., and Yang, Y., 2017
- Cancer therapy in the necroptosis era., Su Z., Yang Z., Xie L., DeWitt J., Chen Y., 2016
- Apoptosis, autophagy, necroptosis, and cancer metastasis., Su, Z., Yang, Z., Xu, Y., Chen, Y., and Yu, Q., 2015
- The synergistic interaction between the calcineurin B subunit and IFN-γ enhances macrophage antitumor activity., Su, Z., Yang, R., Zhang, W., Xu, L., Zhong, Y., Yin, Y., Cen, J., DeWitt, J., and Wei, Q., 2015
