Professor | Steven Y. Cheng | Asia Growth Partners

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Name	Steven Y. Cheng
Contact Information	sycheng@njmu.edu.cn
Language ability	English, Chinese
Province	Jiangsu

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Name

Steven Y. Cheng

Contact Information

sycheng@njmu.edu.cn

Language ability

English, Chinese

Province

Jiangsu

University/Lab Affiliation and Title	Nanjing Medical University
Faculty	Basic Medical Sciences
Academic Background & Achievements	1986 - Bachelor of Science: Peking University 1995 - Ph.D.: University of Wisconsin-Madison Postdoctoral Research: University of California, San Francisco
Work Experience	Before current position - Igen International, Maryland, USA - Biotechnology Company Current - Nanjing Medical University - Distinguished Professor
Awards	Member of the American Cancer Society Lifetime Member of the Society of Chinese Bioscientists in America Council Member of the Chinese Biophysical Society

University/Lab Affiliation and Title

Nanjing Medical University

Faculty

Basic Medical Sciences

Academic Background & Achievements

1986 - Bachelor of Science: Peking University
1995 - Ph.D.: University of Wisconsin-Madison
Postdoctoral Research: University of California, San Francisco

Work Experience

Before current position - Igen International, Maryland, USA - Biotechnology Company
Current - Nanjing Medical University - Distinguished Professor

Awards

Member of the American Cancer Society
Lifetime Member of the Society of Chinese Bioscientists in America
Council Member of the Chinese Biophysical Society

Areas of Focus	Tumor and Developmental Signal Transduction Mechanisms
Publications	The miR-96-182 cluster promotes tumorigenesis in a mouse model of medulloblastoma., Zhang, Z, Li, S, Cheng, SY., 2013 MiR-214 and N-ras regulatory loop suppresses rhabdomyosarcoma cell growth and xenograft tumorigenesis., Huang, HJ, Liu, J, Hua, H, Li, SE, Zhao, J, Yue, S, Yu, TT, Jin, YC, and Cheng,SY., 2014 MicroRNA-206 suppresses gastric cancer cell growth and metastasis., Ren, J, Huang, HJ, Gong, Y, Yue, S, Tang, LM, and Cheng,SY., 2014 Requirement of Smurf-mediated Endocytosis of Patched1 in Sonic Hedgehog Signal Reception., Yue, S, Tang, LY, Tang, Y, Tang, Y, Shen, QH, Ding, J, Chen, Y, Zhang, Z, Yu, TT, Zhang, YE, and Cheng,SY., 2014 MicroRNA-31 suppresses medulloblastoma cell growth by inhibiting DNA replication through Minichromosome maintenance 2., Jin, Y, Xiong, A, Zhang, Z,Yu, TT, Cao, X , and Cheng, SY., 2014 Up-regulation of the Hippo pathway effector TAZ renders lung adenocarcinoma cells harboring EGFR-T790M mutation resistant to Gefitinib., Xu, W, Wei, Y, Wu, SS, Wang, Z, Sun, Y, Cheng SY, and Wu, JQ, 2015 Set7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway in mammals., Fu L, Wu H, Cheng SY, Gao D, Zhang L, and Zhao Y., 2016 Suppressor of Fused chaperones Gli proteins to generate transcriptional responses to Sonic Hedgehog signaling., Zhang, ZY, Huang, HJ, Kelvin, L, Liu, XT, Shen, LY, Hua, H, Zhang, ZD, Li, SE, Yu, TT, Yue, S, C Hui, CC, and Cheng SY., 2016 DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle., Zhang B, Wang G, Xu X, Yang S, Zhuang T, Wang G, Ren H, Cheng SY, Jiang Q, Zhang C., 2017 DeSUMOylation of Gli1 by SENP1 attenuates Sonic hedgehog signaling., Liu HZ, Ding J, Yan S, Yu TT, and Cheng SY., 2017 Diacylglycerol kinase δ triggers endoplasmic reticulum release of IFT88-containing vesicles destined for supporting the assembly of primary cilia., Ding J, Shao L, Liu HZ, Yue S, Xie L, and Cheng SY., 2017 Extramitochondrial prosurvival Bcl-2 proteins regulate gene transcription by disarming the SUFU tumor suppressor., Wu X, Zhang LS, Toombs J, Kuo YC, Piazza JT, Tuladhar R, Barrett Q, Fan CW, Zhang X, Walensky LD, Kool M, Cheng SY, Brekken R, Opferman JT, Green DR, Moldoveanu T, Lum L., 2017

Areas of Focus

Tumor and Developmental Signal Transduction Mechanisms

Publications

The miR-96-182 cluster promotes tumorigenesis in a mouse model of medulloblastoma., Zhang, Z, Li, S, Cheng, SY., 2013
MiR-214 and N-ras regulatory loop suppresses rhabdomyosarcoma cell growth and xenograft tumorigenesis., Huang, HJ, Liu, J, Hua, H, Li, SE, Zhao, J, Yue, S, Yu, TT, Jin, YC, and Cheng,SY., 2014
MicroRNA-206 suppresses gastric cancer cell growth and metastasis., Ren, J, Huang, HJ, Gong, Y, Yue, S, Tang, LM, and Cheng,SY., 2014
Requirement of Smurf-mediated Endocytosis of Patched1 in Sonic Hedgehog Signal Reception., Yue, S, Tang, LY, Tang, Y, Tang, Y, Shen, QH, Ding, J, Chen, Y, Zhang, Z, Yu, TT, Zhang, YE, and Cheng,SY., 2014
MicroRNA-31 suppresses medulloblastoma cell growth by inhibiting DNA replication through Minichromosome maintenance 2., Jin, Y, Xiong, A, Zhang, Z,Yu, TT, Cao, X , and Cheng, SY., 2014
Up-regulation of the Hippo pathway effector TAZ renders lung adenocarcinoma cells harboring EGFR-T790M mutation resistant to Gefitinib., Xu, W, Wei, Y, Wu, SS, Wang, Z, Sun, Y, Cheng SY*, and Wu, JQ*, 2015
Set7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway in mammals., Fu L, Wu H, Cheng SY, Gao D, Zhang L, and Zhao Y., 2016
Suppressor of Fused chaperones Gli proteins to generate transcriptional responses to Sonic Hedgehog signaling., Zhang, ZY, Huang, HJ, Kelvin, L, Liu, XT, Shen, LY, Hua, H, Zhang, ZD, Li, SE, Yu, TT, Yue, S, C Hui, CC, and Cheng SY., 2016
DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle., Zhang B, Wang G, Xu X, Yang S, Zhuang T, Wang G, Ren H, Cheng SY, Jiang Q, Zhang C., 2017
DeSUMOylation of Gli1 by SENP1 attenuates Sonic hedgehog signaling., Liu HZ, Ding J, Yan S, Yu TT, and Cheng SY., 2017
Diacylglycerol kinase δ triggers endoplasmic reticulum release of IFT88-containing vesicles destined for supporting the assembly of primary cilia., Ding J, Shao L, Liu HZ, Yue S, Xie L, and Cheng SY., 2017
Extramitochondrial prosurvival Bcl-2 proteins regulate gene transcription by disarming the SUFU tumor suppressor., Wu X, Zhang LS, Toombs J, Kuo YC, Piazza JT, Tuladhar R, Barrett Q, Fan CW, Zhang X, Walensky LD, Kool M, Cheng SY, Brekken R, Opferman JT, Green DR, Moldoveanu T, Lum L., 2017

Sonic Hedgehog Signal Transduction Tumorigenesis Morphogenesis Cell Differentiation Ubiquitin Ligase Patched1 Sufu Gli Proteins Sumoylation

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