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Yuanyuan Ruan
Basic Medical Sciences
Fudan University
Shanghai
Language: Chinese, English
Glycosylation
Tumorigenesis
Signal Transduction
Protein Translation
Precancerous Lesions
Digestive System
Intervention Strategies
Post-Translational Modification
Cancer
Biochemistry
Areas of Focus
- Post-translational modification of proteins (glycosylation) and tumorigenesis
- Tumor-related signal transduction and abnormal protein translation
- Mechanisms and intervention strategies for precancerous lesions of digestive system tumors
Work Experience
- 2010.07—2012.09 - Fudan University - Postdoctoral Researcher in Basic Medicine
- 2012.09—2013.12 - Fudan University - Lecturer in Basic Medicine
- 2013.12—2018.12 - Fudan University - Associate Researcher in Basic Medicine
- 2018.12—Present - Fudan University - Professor in Basic Medicine
Academic Background & Achievements
- 2000.09—2005.06 Bachelor's Degree in Forensic Medicine: Fudan University Shanghai Medical College
- 2005.09—2010.06 Ph.D. in Biochemistry and Molecular Biology: Fudan University Shanghai Medical College
Publications
- Reticulon 3-mediated Chk2/p53 activation suppresses hepatocellular carcinogenesis and is blocked by hepatitis B virus., Song S, Shi Y, Wu W, Wu H, Chang L, Peng P, Zhang L, Fan J, Gu J, Ruan Y*, 2021
- O-GlcNAcylation of RACK1 promotes hepatocellular carcinogenesis., Duan F, Wu H, Jia D, Wu W, Ren S, Wang L, Song S, Guo X, Liu F*, Ruan Y*, Gu J, 2018
- C-Type Lectin-Like Receptor 2 Suppresses AKT Signaling and Invasive Activities of Gastric Cancer Cells by Blocking Expression of Phosphoinositide 3-Kinase Subunits., Wang L#, Yin J#, Wang X#, Shao M, Duan F, Wu W, Peng P, Jin J, Tang Y, Ruan Y*, Sun Y*, Gu J*, 2016
- Loss of RACK1 Promotes Metastasis of Gastric Cancer by Inducing a miR-302c/IL8 Signaling Loop., Chen L#, Min L#, Wang X#, Zhao J, Chen H, Qin J, Chen W, Shen Z, Tang Z, Gan Q, Ruan Y*, Sun Y*, Qin X*, Gu J, 2015
- Ribosomal RACK1 promotes chemoresistance and growth in human hepatocellular carcinoma., Ruan Y, Sun L, Hao Y, Wang L, Xu J, Zhang W, Xie J, Guo L, Zhou L, Yun X, Zhu H, Shen A, Gu J*, 2012
Awards
- 2019: Zhongying Young Scholar, Fudan University
- 2015: Outstanding Postdoctoral Fellow, Fudan University
