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程雁
Basic Medical Sciences
南京医科大学
江苏
Language: 英语, 中文
Sonic Hedgehog
信号转导
肿瘤发生
形态发生
细胞分化
泛素连接酶
Patched1
Sufu
Gli蛋白
Sumo化
Areas of Focus
- 肿瘤与发育信号转导机制
Work Experience
- 在现任职位之前 - Igen International, 马里兰州, 美国 - 生物技术公司
- 现任 - 南京医科大学 - 特聘教授
Academic Background & Achievements
- 1986 - 理学士学位: 北京大学
- 1995 - 博士学位: 威斯康星大学麦迪逊分校
- 博士后研究: 加州大学旧金山分校
Publications
- The miR-96-182 cluster promotes tumorigenesis in a mouse model of medulloblastoma., Zhang, Z, Li, S, Cheng, SY., 2013
- MiR-214 and N-ras regulatory loop suppresses rhabdomyosarcoma cell growth and xenograft tumorigenesis., Huang, HJ, Liu, J, Hua, H, Li, SE, Zhao, J, Yue, S, Yu, TT, Jin, YC, and Cheng,SY., 2014
- MicroRNA-206 suppresses gastric cancer cell growth and metastasis., Ren, J, Huang, HJ, Gong, Y, Yue, S, Tang, LM, and Cheng,SY., 2014
- Requirement of Smurf-mediated Endocytosis of Patched1 in Sonic Hedgehog Signal Reception., Yue, S, Tang, LY, Tang, Y, Tang, Y, Shen, QH, Ding, J, Chen, Y, Zhang, Z, Yu, TT, Zhang, YE, and Cheng,SY., 2014
- MicroRNA-31 suppresses medulloblastoma cell growth by inhibiting DNA replication through Minichromosome maintenance 2., Jin, Y, Xiong, A, Zhang, Z,Yu, TT, Cao, X , and Cheng, SY., 2014
- Up-regulation of the Hippo pathway effector TAZ renders lung adenocarcinoma cells harboring EGFR-T790M mutation resistant to Gefitinib., Xu, W, Wei, Y, Wu, SS, Wang, Z, Sun, Y, Cheng SY*, and Wu, JQ*, 2015
- Set7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway in mammals., Fu L, Wu H, Cheng SY, Gao D, Zhang L, and Zhao Y., 2016
- Suppressor of Fused chaperones Gli proteins to generate transcriptional responses to Sonic Hedgehog signaling., Zhang, ZY, Huang, HJ, Kelvin, L, Liu, XT, Shen, LY, Hua, H, Zhang, ZD, Li, SE, Yu, TT, Yue, S, C Hui, CC, and Cheng SY., 2016
- DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle., Zhang B, Wang G, Xu X, Yang S, Zhuang T, Wang G, Ren H, Cheng SY, Jiang Q, Zhang C., 2017
- DeSUMOylation of Gli1 by SENP1 attenuates Sonic hedgehog signaling., Liu HZ, Ding J, Yan S, Yu TT, and Cheng SY., 2017
- Diacylglycerol kinase δ triggers endoplasmic reticulum release of IFT88-containing vesicles destined for supporting the assembly of primary cilia., Ding J, Shao L, Liu HZ, Yue S, Xie L, and Cheng SY., 2017
- Extramitochondrial prosurvival Bcl-2 proteins regulate gene transcription by disarming the SUFU tumor suppressor., Wu X, Zhang LS, Toombs J, Kuo YC, Piazza JT, Tuladhar R, Barrett Q, Fan CW, Zhang X, Walensky LD, Kool M, Cheng SY, Brekken R, Opferman JT, Green DR, Moldoveanu T, Lum L., 2017
Awards
- 美国癌症学会会员
- 世界华人生物科学家学会终身会员
- 中国生物物理学会理事
