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Xin Cao
Basic Medical Sciences
Nanjing Medical University
Jiangsu
Language: Chinese, English
Auditory Dysfunction
Molecular Genetics
Hearing Loss
Genetic Mechanisms
Deafness
Genetic Research
Auditory System
Genetic Mutations
Hearing Disorders
Genetic Phenotypes
Areas of Focus
- Molecular genetic mechanisms of auditory dysfunction
Work Experience
- 1994/07 - 1998/08 - Shihezi University School of Medicine - Lecturer/Associate Professor
- 2001/07 - 2002/01 - Shihezi University School of Life Sciences - Associate Professor
- 2002/02 - Present - Nanjing Medical University School of Basic Medical Sciences - Associate Professor/Professor
- 2005/03 - 2006/05 - University of Pennsylvania School of Medicine - Visiting Scholar
Academic Background & Achievements
- 1991/09 - 1994/06 Master's in Medicine: Sichuan University Huaxi Medical Center
- 1998/09 - 2001/06 PhD in Science: Shanghai Jiao Tong University School of Medicine
- Co-editor of the textbook 'Introduction to Biomedical Science' (2nd edition)
Publications
- Mutations in OSBPL2 cause hearing loss associated with primary cilia defects via Sonic Hedgehog signaling., Shi H, Wang H, Zhang C, Lu Y, Yao J, Chen Z, Xing G, Wei Q, Cao X, 2022
- Oxysterol-binding protein-like 2 contributes to the developmental progression of preadipocytes by binding to β-catenin., Wang T, Zhang T, Tang Y, Wang H, Wei Q, Lu Y, Yao J, Qu Y, Cao X, 2021
- OSBPL2 is required for the binding of COPB1 to ATGL and the regulation of lipid droplet lipolysis., Wang T, Wei Q, Liang L, Tang X, Yao J, Lu Y, Qu Y, Chen Z, Xing G, Cao X, 2020
- OSBPL2 deficiency upregulate SQLE expression increasing intracellular cholesterol and cholesteryl ester by AMPK/SP1 and SREBF2 signaling pathway., Zhang C, Zhang H, Zhang M, Lin C, Wang H, Yao J, Wei Q, Lu Y, Chen Z, Xing G, Cao X, 2019
- Deletion of OSBPL2 in auditory cells increases cholesterol biosynthesis and drives reactive oxygen species production by inhibiting AMPK activity., Wang H, Lin C, Yao J, Shi H, Zhang C, Wei Q, Lu Y, Chen Z, Xing G, Cao X, 2019
- OSBPL2-disrupted pigs recapitulate dual features of human hearing loss and hypercholesterolaemia., Yao J, Zeng H, Zhang M, Wei Q, Wang Y, Yang H, Lu Y, Li R, Xiong Q, Zhang L, Chen Z, Xing G, Cao X, Dai Y, 2019
- 25-hydroxycholesterol down-regulates oxysterol binding protein like 2 (OSBPL2) via the p53/SREBF2/NFYA signaling pathway., Wang Q, Lin C, Zhang C, Wang H, Lu Y, Yao J, Wei Q, Xing G, Cao X, 2019
- Genetic analysis of CLDN14 in the Chinese population affected with non-syndromic hearing loss., Lu Y, Yao J, Wei Q, Xu J, Xing G, Cao X, 2018
- GPRASP2, a novel causative gene mutated in an X-linked recessive syndromic hearing loss., Xing G, Yao J, Liu C, Wei Q, Qian X, Wu L, Lu Y, Cao X, 2017
- Spatial and temporal expression patterns of Osbpl2a and Osbpl2b during zebrafish embryonic development., Liu C, Yao J, Wei Q, Xing G, Cao X, 2016
- Identification of OSBPL2 as a novel candidate gene for progressive nonsyndromic hearing loss by whole-exome sequencing., Xing G, Yao J, Wu B, Liu T, Wei Q, Liu C, Lu Y, Chen Z, Zheng H, Yang X, Cao X, 2015
- OSBPL2突变型基因、其鉴定方法和检测试剂盒, 曹新, 邢光前, 魏钦俊, 姚俊, 陈智斌, 鲁雅洁, 2015
- GPRASP2突变型基因、其鉴定方法和检测试剂盒, 曹新，邢光前，魏钦俊，姚俊，陈智斌，鲁雅洁, 2015
Awards
- Chinese Medical Science and Technology Award Second Prize (2006): Research on clinical features, genetic phenotypes, and molecular mechanisms of hereditary deafness
- Jiangsu Provincial Health Department Medical New Technology Introduction Second Prize (2011): Application of microarray chip technology in gene diagnosis of deafness
