Professor | Xin Cao | Asia Growth Partners

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Name	Xin Cao
Contact Information	caoxin@njmu.edu.cn
Language ability	Chinese, English
Province	Jiangsu

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Name

Xin Cao

Contact Information

caoxin@njmu.edu.cn

Language ability

Chinese, English

Province

Jiangsu

University/Lab Affiliation and Title	Nanjing Medical University
Faculty	Basic Medical Sciences
Academic Background & Achievements	1991/09 - 1994/06 Master's in Medicine: Sichuan University Huaxi Medical Center 1998/09 - 2001/06 PhD in Science: Shanghai Jiao Tong University School of Medicine Co-editor of the textbook 'Introduction to Biomedical Science' (2nd edition)
Work Experience	1994/07 - 1998/08 - Shihezi University School of Medicine - Lecturer/Associate Professor 2001/07 - 2002/01 - Shihezi University School of Life Sciences - Associate Professor 2002/02 - Present - Nanjing Medical University School of Basic Medical Sciences - Associate Professor/Professor 2005/03 - 2006/05 - University of Pennsylvania School of Medicine - Visiting Scholar
Awards	Chinese Medical Science and Technology Award Second Prize (2006): Research on clinical features, genetic phenotypes, and molecular mechanisms of hereditary deafness Jiangsu Provincial Health Department Medical New Technology Introduction Second Prize (2011): Application of microarray chip technology in gene diagnosis of deafness

University/Lab Affiliation and Title

Nanjing Medical University

Faculty

Basic Medical Sciences

Academic Background & Achievements

1991/09 - 1994/06 Master's in Medicine: Sichuan University Huaxi Medical Center
1998/09 - 2001/06 PhD in Science: Shanghai Jiao Tong University School of Medicine
Co-editor of the textbook 'Introduction to Biomedical Science' (2nd edition)

Work Experience

1994/07 - 1998/08 - Shihezi University School of Medicine - Lecturer/Associate Professor
2001/07 - 2002/01 - Shihezi University School of Life Sciences - Associate Professor
2002/02 - Present - Nanjing Medical University School of Basic Medical Sciences - Associate Professor/Professor
2005/03 - 2006/05 - University of Pennsylvania School of Medicine - Visiting Scholar

Awards

Chinese Medical Science and Technology Award Second Prize (2006): Research on clinical features, genetic phenotypes, and molecular mechanisms of hereditary deafness
Jiangsu Provincial Health Department Medical New Technology Introduction Second Prize (2011): Application of microarray chip technology in gene diagnosis of deafness

Areas of Focus	Molecular genetic mechanisms of auditory dysfunction
Publications	Mutations in OSBPL2 cause hearing loss associated with primary cilia defects via Sonic Hedgehog signaling., Shi H, Wang H, Zhang C, Lu Y, Yao J, Chen Z, Xing G, Wei Q, Cao X, 2022 Oxysterol-binding protein-like 2 contributes to the developmental progression of preadipocytes by binding to β-catenin., Wang T, Zhang T, Tang Y, Wang H, Wei Q, Lu Y, Yao J, Qu Y, Cao X, 2021 OSBPL2 is required for the binding of COPB1 to ATGL and the regulation of lipid droplet lipolysis., Wang T, Wei Q, Liang L, Tang X, Yao J, Lu Y, Qu Y, Chen Z, Xing G, Cao X, 2020 OSBPL2 deficiency upregulate SQLE expression increasing intracellular cholesterol and cholesteryl ester by AMPK/SP1 and SREBF2 signaling pathway., Zhang C, Zhang H, Zhang M, Lin C, Wang H, Yao J, Wei Q, Lu Y, Chen Z, Xing G, Cao X, 2019 Deletion of OSBPL2 in auditory cells increases cholesterol biosynthesis and drives reactive oxygen species production by inhibiting AMPK activity., Wang H, Lin C, Yao J, Shi H, Zhang C, Wei Q, Lu Y, Chen Z, Xing G, Cao X, 2019 OSBPL2-disrupted pigs recapitulate dual features of human hearing loss and hypercholesterolaemia., Yao J, Zeng H, Zhang M, Wei Q, Wang Y, Yang H, Lu Y, Li R, Xiong Q, Zhang L, Chen Z, Xing G, Cao X, Dai Y, 2019 25-hydroxycholesterol down-regulates oxysterol binding protein like 2 (OSBPL2) via the p53/SREBF2/NFYA signaling pathway., Wang Q, Lin C, Zhang C, Wang H, Lu Y, Yao J, Wei Q, Xing G, Cao X, 2019 Genetic analysis of CLDN14 in the Chinese population affected with non-syndromic hearing loss., Lu Y, Yao J, Wei Q, Xu J, Xing G, Cao X, 2018 GPRASP2, a novel causative gene mutated in an X-linked recessive syndromic hearing loss., Xing G, Yao J, Liu C, Wei Q, Qian X, Wu L, Lu Y, Cao X, 2017 Spatial and temporal expression patterns of Osbpl2a and Osbpl2b during zebrafish embryonic development., Liu C, Yao J, Wei Q, Xing G, Cao X, 2016 Identification of OSBPL2 as a novel candidate gene for progressive nonsyndromic hearing loss by whole-exome sequencing., Xing G, Yao J, Wu B, Liu T, Wei Q, Liu C, Lu Y, Chen Z, Zheng H, Yang X, Cao X, 2015 OSBPL2突变型基因、其鉴定方法和检测试剂盒, 曹新, 邢光前, 魏钦俊, 姚俊, 陈智斌, 鲁雅洁, 2015 GPRASP2突变型基因、其鉴定方法和检测试剂盒, 曹新，邢光前，魏钦俊，姚俊，陈智斌，鲁雅洁, 2015

Areas of Focus

Molecular genetic mechanisms of auditory dysfunction

Publications

Mutations in OSBPL2 cause hearing loss associated with primary cilia defects via Sonic Hedgehog signaling., Shi H, Wang H, Zhang C, Lu Y, Yao J, Chen Z, Xing G, Wei Q, Cao X, 2022
Oxysterol-binding protein-like 2 contributes to the developmental progression of preadipocytes by binding to β-catenin., Wang T, Zhang T, Tang Y, Wang H, Wei Q, Lu Y, Yao J, Qu Y, Cao X, 2021
OSBPL2 is required for the binding of COPB1 to ATGL and the regulation of lipid droplet lipolysis., Wang T, Wei Q, Liang L, Tang X, Yao J, Lu Y, Qu Y, Chen Z, Xing G, Cao X, 2020
OSBPL2 deficiency upregulate SQLE expression increasing intracellular cholesterol and cholesteryl ester by AMPK/SP1 and SREBF2 signaling pathway., Zhang C, Zhang H, Zhang M, Lin C, Wang H, Yao J, Wei Q, Lu Y, Chen Z, Xing G, Cao X, 2019
Deletion of OSBPL2 in auditory cells increases cholesterol biosynthesis and drives reactive oxygen species production by inhibiting AMPK activity., Wang H, Lin C, Yao J, Shi H, Zhang C, Wei Q, Lu Y, Chen Z, Xing G, Cao X, 2019
OSBPL2-disrupted pigs recapitulate dual features of human hearing loss and hypercholesterolaemia., Yao J, Zeng H, Zhang M, Wei Q, Wang Y, Yang H, Lu Y, Li R, Xiong Q, Zhang L, Chen Z, Xing G, Cao X, Dai Y, 2019
25-hydroxycholesterol down-regulates oxysterol binding protein like 2 (OSBPL2) via the p53/SREBF2/NFYA signaling pathway., Wang Q, Lin C, Zhang C, Wang H, Lu Y, Yao J, Wei Q, Xing G, Cao X, 2019
Genetic analysis of CLDN14 in the Chinese population affected with non-syndromic hearing loss., Lu Y, Yao J, Wei Q, Xu J, Xing G, Cao X, 2018
GPRASP2, a novel causative gene mutated in an X-linked recessive syndromic hearing loss., Xing G, Yao J, Liu C, Wei Q, Qian X, Wu L, Lu Y, Cao X, 2017
Spatial and temporal expression patterns of Osbpl2a and Osbpl2b during zebrafish embryonic development., Liu C, Yao J, Wei Q, Xing G, Cao X, 2016
Identification of OSBPL2 as a novel candidate gene for progressive nonsyndromic hearing loss by whole-exome sequencing., Xing G, Yao J, Wu B, Liu T, Wei Q, Liu C, Lu Y, Chen Z, Zheng H, Yang X, Cao X, 2015
OSBPL2突变型基因、其鉴定方法和检测试剂盒, 曹新, 邢光前, 魏钦俊, 姚俊, 陈智斌, 鲁雅洁, 2015
GPRASP2突变型基因、其鉴定方法和检测试剂盒, 曹新，邢光前，魏钦俊，姚俊，陈智斌，鲁雅洁, 2015

Auditory Dysfunction Molecular Genetics Hearing Loss Genetic Mechanisms Deafness Genetic Research Auditory System Genetic Mutations Hearing Disorders Genetic Phenotypes

Li Chen - Fudan University

Jun Yao - Nanjing Medical University

Zhang Xue - Peking Union Medical College

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