Professor | 曹新 | 数字化转型顾问

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Name	曹新
Contact Information	caoxin@njmu.edu.cn
Language ability	中文, 英文
Province	江苏

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Name

曹新

Contact Information

caoxin@njmu.edu.cn

Language ability

中文, 英文

Province

江苏

University/Lab Affiliation and Title	南京医科大学
Faculty	Basic Medical Sciences
Academic Background & Achievements	1991/09 - 1994/06 医学硕士: 四川大学华西医学中心 1998/09 - 2001/06 理学博士: 上海交通大学医学院共同主编《生物医学导论》第二版
Work Experience	1994/07 - 1998/08 - 石河子大学医学院 - 讲师/副教授 2001/07 - 2002/01 - 石河子大学生命科学学院 - 副教授 2002/02 - 至今 - 南京医科大学基础医学院 - 副教授/教授 2005/03 - 2006/05 - 美国宾夕法尼亚大学医学院 - 访问学者
Awards	中华医学科技奖二等奖 (2006): 中国遗传性耳聋大家系临床特征、遗传表型及致聋分子机制的研究江苏省卫生厅医学新技术引进二等奖 (2011): 微阵列芯片技术在耳聋基因诊断中的应用

University/Lab Affiliation and Title

南京医科大学

Faculty

Basic Medical Sciences

Academic Background & Achievements

1991/09 - 1994/06 医学硕士: 四川大学华西医学中心
1998/09 - 2001/06 理学博士: 上海交通大学医学院
共同主编《生物医学导论》第二版

Work Experience

1994/07 - 1998/08 - 石河子大学医学院 - 讲师/副教授
2001/07 - 2002/01 - 石河子大学生命科学学院 - 副教授
2002/02 - 至今 - 南京医科大学基础医学院 - 副教授/教授
2005/03 - 2006/05 - 美国宾夕法尼亚大学医学院 - 访问学者

Awards

中华医学科技奖二等奖 (2006): 中国遗传性耳聋大家系临床特征、遗传表型及致聋分子机制的研究
江苏省卫生厅医学新技术引进二等奖 (2011): 微阵列芯片技术在耳聋基因诊断中的应用

Areas of Focus	听觉功能异常的分子遗传机制
Publications	Mutations in OSBPL2 cause hearing loss associated with primary cilia defects via Sonic Hedgehog signaling., Shi H, Wang H, Zhang C, Lu Y, Yao J, Chen Z, Xing G, Wei Q, Cao X, 2022 Oxysterol-binding protein-like 2 contributes to the developmental progression of preadipocytes by binding to β-catenin., Wang T, Zhang T, Tang Y, Wang H, Wei Q, Lu Y, Yao J, Qu Y, Cao X, 2021 OSBPL2 is required for the binding of COPB1 to ATGL and the regulation of lipid droplet lipolysis., Wang T, Wei Q, Liang L, Tang X, Yao J, Lu Y, Qu Y, Chen Z, Xing G, Cao X, 2020 OSBPL2 deficiency upregulate SQLE expression increasing intracellular cholesterol and cholesteryl ester by AMPK/SP1 and SREBF2 signaling pathway., Zhang C, Zhang H, Zhang M, Lin C, Wang H, Yao J, Wei Q, Lu Y, Chen Z, Xing G, Cao X, 2019 Deletion of OSBPL2 in auditory cells increases cholesterol biosynthesis and drives reactive oxygen species production by inhibiting AMPK activity., Wang H, Lin C, Yao J, Shi H, Zhang C, Wei Q, Lu Y, Chen Z, Xing G, Cao X, 2019 OSBPL2-disrupted pigs recapitulate dual features of human hearing loss and hypercholesterolaemia., Yao J, Zeng H, Zhang M, Wei Q, Wang Y, Yang H, Lu Y, Li R, Xiong Q, Zhang L, Chen Z, Xing G, Cao X, Dai Y, 2019 25-hydroxycholesterol down-regulates oxysterol binding protein like 2 (OSBPL2) via the p53/SREBF2/NFYA signaling pathway., Wang Q, Lin C, Zhang C, Wang H, Lu Y, Yao J, Wei Q, Xing G, Cao X, 2019 Genetic analysis of CLDN14 in the Chinese population affected with non-syndromic hearing loss., Lu Y, Yao J, Wei Q, Xu J, Xing G, Cao X, 2018 GPRASP2, a novel causative gene mutated in an X-linked recessive syndromic hearing loss., Xing G, Yao J, Liu C, Wei Q, Qian X, Wu L, Lu Y, Cao X, 2017 Spatial and temporal expression patterns of Osbpl2a and Osbpl2b during zebrafish embryonic development., Liu C, Yao J, Wei Q, Xing G, Cao X, 2016 Identification of OSBPL2 as a novel candidate gene for progressive nonsyndromic hearing loss by whole-exome sequencing., Xing G, Yao J, Wu B, Liu T, Wei Q, Liu C, Lu Y, Chen Z, Zheng H, Yang X, Cao X, 2015 OSBPL2突变型基因、其鉴定方法和检测试剂盒, 曹新, 邢光前, 魏钦俊, 姚俊, 陈智斌, 鲁雅洁, 2015 GPRASP2突变型基因、其鉴定方法和检测试剂盒, 曹新，邢光前，魏钦俊，姚俊，陈智斌，鲁雅洁, 2015

Areas of Focus

听觉功能异常的分子遗传机制

Publications

Mutations in OSBPL2 cause hearing loss associated with primary cilia defects via Sonic Hedgehog signaling., Shi H, Wang H, Zhang C, Lu Y, Yao J, Chen Z, Xing G, Wei Q, Cao X, 2022
Oxysterol-binding protein-like 2 contributes to the developmental progression of preadipocytes by binding to β-catenin., Wang T, Zhang T, Tang Y, Wang H, Wei Q, Lu Y, Yao J, Qu Y, Cao X, 2021
OSBPL2 is required for the binding of COPB1 to ATGL and the regulation of lipid droplet lipolysis., Wang T, Wei Q, Liang L, Tang X, Yao J, Lu Y, Qu Y, Chen Z, Xing G, Cao X, 2020
OSBPL2 deficiency upregulate SQLE expression increasing intracellular cholesterol and cholesteryl ester by AMPK/SP1 and SREBF2 signaling pathway., Zhang C, Zhang H, Zhang M, Lin C, Wang H, Yao J, Wei Q, Lu Y, Chen Z, Xing G, Cao X, 2019
Deletion of OSBPL2 in auditory cells increases cholesterol biosynthesis and drives reactive oxygen species production by inhibiting AMPK activity., Wang H, Lin C, Yao J, Shi H, Zhang C, Wei Q, Lu Y, Chen Z, Xing G, Cao X, 2019
OSBPL2-disrupted pigs recapitulate dual features of human hearing loss and hypercholesterolaemia., Yao J, Zeng H, Zhang M, Wei Q, Wang Y, Yang H, Lu Y, Li R, Xiong Q, Zhang L, Chen Z, Xing G, Cao X, Dai Y, 2019
25-hydroxycholesterol down-regulates oxysterol binding protein like 2 (OSBPL2) via the p53/SREBF2/NFYA signaling pathway., Wang Q, Lin C, Zhang C, Wang H, Lu Y, Yao J, Wei Q, Xing G, Cao X, 2019
Genetic analysis of CLDN14 in the Chinese population affected with non-syndromic hearing loss., Lu Y, Yao J, Wei Q, Xu J, Xing G, Cao X, 2018
GPRASP2, a novel causative gene mutated in an X-linked recessive syndromic hearing loss., Xing G, Yao J, Liu C, Wei Q, Qian X, Wu L, Lu Y, Cao X, 2017
Spatial and temporal expression patterns of Osbpl2a and Osbpl2b during zebrafish embryonic development., Liu C, Yao J, Wei Q, Xing G, Cao X, 2016
Identification of OSBPL2 as a novel candidate gene for progressive nonsyndromic hearing loss by whole-exome sequencing., Xing G, Yao J, Wu B, Liu T, Wei Q, Liu C, Lu Y, Chen Z, Zheng H, Yang X, Cao X, 2015
OSBPL2突变型基因、其鉴定方法和检测试剂盒, 曹新, 邢光前, 魏钦俊, 姚俊, 陈智斌, 鲁雅洁, 2015
GPRASP2突变型基因、其鉴定方法和检测试剂盒, 曹新，邢光前，魏钦俊，姚俊，陈智斌，鲁雅洁, 2015

听觉功能异常分子遗传学听力损失遗传机制耳聋遗传研究听觉系统基因突变听力障碍遗传表型

陈莉 - 复旦大学

张学 - 北京协和医学院

姚俊 - 南京医科大学

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