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Renhong Du
Basic Medical Sciences
Nanjing Medical University
Jiangsu
Language: Chinese, English
Neurodegenerative Diseases
Pathogenesis
Drug Targets
Neuropharmacology
Parkinson'S Disease
Microglia
Astrocytes
Inflammation
Mitophagy
Nlrp3 Inflammasome
Areas of Focus
- Pathogenesis and drug targets of neurodegenerative diseases
Work Experience
- 2010-2018 - Nanjing Medical University - Lecturer in Pharmacology
- 2018-present - Nanjing Medical University - Associate Professor in Pharmacology
Academic Background & Achievements
- 1998-2003 Clinical Medicine: Wannan Medical College
- 2005-2010 PhD in Pharmacology: Sun Yat-sen University
- Published 16 SCI papers as first/corresponding author with a cumulative impact factor of 80
Publications
- Astragaloside IV inhibits astrocyte senescence: implication in Parkinson's disease, Xia ML, Xie XH, Ding JH, Du RH*, Hu G*, 2020
- Kir6.1/K-ATP channel on astrocytes protects against dopaminergic neurodegeneration in the MPTP mouse model of Parkinson's disease via promoting mitophagy, Hu ZL, Sun T, Lu M, Ding JH, Du RH*, Hu G*, 2019
- Astrocyte-specific deletion of Kir6.1/K-ATP channel aggravates cerebral ischemia/reperfusion injury through endoplasmic reticulum stress in mice, Zhong CJ, Chen MM, Lu M, Ding JH, Du RH*, Hu G*, 2019
- The pore-forming subunit Kir6.1 of the K-ATP channel negatively regulates the NLRP3 inflammasome to control insulin resistance by interacting with NLRP3, Du RH, Lu M, Wang C, Ding JH, Wu G, Hu G*, 2019
- Kir6.1/K-ATP channel modulates microglia phenotypes: implication in Parkinson's disease, Du RH, Sun HB, Hu ZL, Lu M, Ding JH, Hu G*, 2018
- α-Synuclein disrupts the anti-inflammatory role of Drd2 via interfering β-arrestin2-TAB1 interaction in astrocytes, Du RH#, Zhou Y#, Xia ML, Lu M, Ding JH, Hu G, 2018
- MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease, Zhou Y#, Lu M#, Du RH#, Qiao C, Jiang CY, Zhang KZ, Ding JH, and Hu G*, 2016
- Uncoupling protein 2 modulation of the NLRP3 inflammasome in astrocytes and its implications in depression, Du RH#, Wu FF#, Lu M#, Shu XD, Ding JH, Wu G, Hu G*, 2016
- Fluoxetine Inhibits NLRP3 Inflammasome Activation: Implication in Depression, Du RH, Tan J, Sun XY, Lu M, Ding JH, Hu G, 2016
- Endophilin A2 Influences Volume-Regulated Chloride Current by Mediating ClC-3 Trafficking in Vascular Smooth Muscle Cells, Liu CZ#, Li XY#, Du RH#, Gao M, Ma MM, Li FY, Huang EW, Sun HS, Wang GL, Guan YY, 2016
- β-Arrestin 2 mediates the anti-inflammatory effects of fluoxetine in lipopolysaccharide-stimulated microglial cells, Du RW, Du RH*, Bu WG*, 2014
- Kir6.2-containing ATP-sensitive K(+) channel is required for cardioprotection of resveratrol in mice, Du RH, Dai T, Cao WJ, Lu M, Ding JH, Hu G, 2014
- Kir6.2 knockout aggravates lipopolysaccharide-induced mouse liver injury via enhancing NLRP3 inflammasome activation, Du RH, Tan J, Yan N, Wang L, Qiao C, Ding JH, Lu M, Hu G, 2014
