Medical Bachelor's and Master's degrees: Southern Medical University, Guangzhou
PhD in Genetics: Fudan University, Shanghai
Postdoctoral training in Molecular Oncology: PUMC & CAMS, Beijing
Postdoctoral training in Genomics: Yale University, USA
Published over 110 papers, including in Nature and Cell
Authored 6 books in Chinese and English
Holds 14 US-China invention patents
Current - Southern Medical University - Professor and Director of Biochemistry and Molecular Biology
Previous - Yale University - Researcher and Project PI in Genetics
CastUSA Single Cell Genomics Pioneer Award
Vebleo Fellow of International Scientific Organization
Specially Appointed Expert of the Chinese Federation of Returned Overseas Chinese
Research
Single cell technology innovation Cancer heterogeneity and biomarker Genome medicine Single cell bioinformatics Stem cell and regenerative medicine
Shortcut barcoding and early pooling for scalable multiplex single-cell reduced-representation CpG methylation sequencing at single nucleotide resolution., Liyao Mai, Zebin Wen, Yulong Zhang, Yu Gao, Guanchuan Lin, Zhiwei Lian, Xiang Yang, Jingjing Zhou, Xianwei Lin, Chaochao Luo, Wanwan Peng, Caiming Chen, Jiajia Peng, Duolian Liu, Sadie L Marjani, Qian Tao, Yongping Cui, Junxiao Zhang, Xuedong Wu, Sherman M Weissman, Xinghua Pan., 2023
A CCL2+DPP4+ subset of mesenchymal stem cells expedites aberrant formation of creeping fat in humans., Lan Bai, Fengfei Wu, Fangting Wu, Qian Zhou, Xi Liu, Jieying Fei, Da Zhang, Weidong Wang, Yi Tao, Yubing Lin, Qiaoqiao Lin, Xinghua Pan, Kai Sun, Fang Xie., 2023
Discovery of 194 Unreported Conopeptides and Identification of a New Protein Disulfide Isomerase in Conus caracteristicus Using Integrated Transcriptomic and Proteomic Analysis., Han Zhang, Lei Wang, Yinbin Qiu, Fahui Gong, Baoting Nong, Xinghua Pan., 2022
Preparation and Functional Identification of a Novel Conotoxin QcMNCL-XIII0.1 from Conus quercinus., Han Zhang, Anwen Liang, Xinghua Pan., 2022
Sample‑multiplexing approaches for single‑cell sequencing., Zhang Y, Xu S, Wen Z, Gao JY, Li S, Weissman SM, Pan X., 2022
Tumorigenicity risk of iPSCs in vivo: nip it in the bud., Chaoliang Zhong, Miao Liu, Xinghua Pan, Haiying Zhu., 2022
Identification of Novel Conopeptides and Distinct Gene Superfamilies in the Marine Cone Snail Conus quercinus., Han Zhang, Lei Wang, Xiang Yang, Zhiwei Lian, Yinbin Qiu, Zhanying Dong, Xuedong Wu, Xinghua Pan., 2021
The role of serum amyloid A1 in the adipogenic differentiation of human adipose-derived stem cells basing on single-cell RNA sequencing analysis., Rongmei Qu, Kai He, Yuchao Yang, Tingyu Fan, Bing Sun, Asmat Ullah Khan, Wenhua Huang, Jun Ouyang, Xinghua Pan, Jingxing Dai., 2022
Spatial transcriptome profiling by MERFISH reveals fetal liver hematopoietic stem cell niche architecture., Yanfang Lu, Miao Liu, Jennifer Yang, Sherman Weissman, Xinghua Pan, Samuel Katz, Siyuan Wang., 2021
MustSeq, an alternative approach for multiplexible strand-specific 3' end sequencing of mRNA transcriptome confers high efficiency and practicality., Liyao Mai, Yinbin Qiu, Zhiwei Lian, Caiming Chen, Linlin Wang, Yao Yin, Siqi Wang, Xiang Yang, Yazi Li, Wanwan Peng, Chaochao Luo, Xinghua Pan., 2021
Mitogenome and comprehensive phylogenetic analyses support rapid diversifications among species groups of small-eared shrews, genus Cryptotis (Mammalia: Eulipotyphla: Soricidae)., Kai He, Xing Chen, Yin-Bin Qiu, Zhu Liu, Wen-Zhi Wang, Neal Woodman, Jesús E. Maldonado, Xinghua Pan., 2021
Glutamine Regulates Cell Growth and Casein Synthesis through the CYTHs/ARFGAP1-Arf1-mTORC1 Pathway in Bovine Mammary Epithelial Cells., Chaochao Luo, Wanwan Peng, Jia Kang, Caiming Chen, Jiajia Peng, Yue Wang, Qian Tang, Hailong Xie, Yazi Li, Xinghua Pan., 2021
Colorectal Cancer Stem Cell States Uncovered by Simultaneous Single-Cell Analysis of Transcriptome and Telomeres., Wang H, Gong P, Chen T, Gao S, Wu Z, Wang X, Li J, Marjani SL, Costa J, Weissman SM, Qi F, Pan X, Liu L., 2021
Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma., Zhou Y, Yang D, Yang Q, Lv X, Huang W, Zhou Z, Wang Y, Zhang Z, Yuan T, Ding X, Tang L, Zhang J, Yin J, Huang Y, Yu W, Wang Y, Zhou C, Su Y, He A, Sun Y, Shen Z, Qian B, Meng W, Fei J, Yao Y, Pan X, Chen P, Hu H., 2020
Identification of a distinct luminal subgroup diagnosing and stratifying early stage prostate cancer by tissue-based single-cell RNA sequencing., Ma X, Guo J, Liu K, Chen L, Liu D, Dong S, Xia J, Long Q, Yue Y, Zhao P, Hu F, Xiao Z, Pan X, Xiao K, Cheng Z, Ke Z, Chen ZS, Zou C., 2020
Expanded encyclopaedias of DNA elements in the human and mouse genomes., The ENCODE Project Consortium, Jill E Moore, Michael J Purcaro, Henry E Pratt, et al., 2020
Perspectives on ENCODE., The ENCODE Project Consortium, Michael P Snyder, Thomas R Gingeras, et al., 2020
Putative Regulators for the Continuum of Erythroid Differentiation Revealed by Single-cell Transcriptomes of Human Bone Marrow and Umbilical Cord Blood., Huang H, Zhao Y, Zhong J, Zhang X, Liu Q, Qiu X, Chen S, Yang H, Hillyer C, Mohandas N, Pan X, Xu X., 2020
Identification and Single-Cell Analysis of Viable Circulating Tumor Cells by a Mitochondrion-Specific AIE Bioprobe., Situ B, Ye X, Zhao Q, Mai L, Huang Y, Wang S, Chen J, Li B, He B, Zhang Y, Zou J, Tang BJ, Pan X, Zheng L., 2020
An Efficient Bivalent Cyclic RGD-PIK3CB siRNA Conjugate for Specific Targeted Therapy against Glioblastoma In Vitro and In Vivo., Cen B, Wei Y, Huang W, Teng M, He S, Li J, Wang W, He G, Bai X, Liu X, Yuan Y, Pan X, Ji A., 2018
Gelofusine Attenuates Tubulointerstitial Injury Induced by cRGD-Conjugated siRNA by Regulating the TLR3 Signaling Pathway., Cen B, Liao W, Wang Z, Gao L, Wei Y, Huang W, He S, Wang W, Liu X, Pan X, Ji A., 2018
Characterization of cancer genomic heterogeneity by next-generation sequencing advances precision medicine in cancer treatment., Zhang J, Späth SS, Marjani SL, Zhang W, Pan X., 2018
Bisulfite-independent analysis of CpG island methylation enables genome-scale stratification of single cells., Han L, Wu HJ, Zhu H, Kim KY, Marjani SL, Riester M, Euskirchen G, Zi X, Yang J, Han J, Snyder M, Park IH, Irizarry R, Weissman SM, Michor F, Fan R, Pan X., 2017
Single cell transcriptomics reveals unanticipated features of early hematopoietic precursors., Yang J, Tanaka Y, Seay M, Li Z, Jin J, Garmire LX, Zhu X, Taylor A, Li W, Euskirchen G, Halene S, Kluger Y, Snyder MP, Park IH, Pan X, Weissman SM., 2017
Evolution and heterogeneity of non-hereditary colorectal cancer revealed by single-cell exome sequencing., Wu H, Zhang XY, Hu Z, Hou Q, Zhang H, Li Y, Li S, Yue J, Jiang Z, Weissman SW, Pan X, Ju BG, Wu S., 2017
Next-generation molecular diagnosis: single-cell sequencing from bench to bedside., Zhu W, Zhang XY, Marjani SL, Zhang J, Zhang W, Wu S, Pan X., 2017
Single-Cell Sequencing for Precise Cancer Research: Progress and Prospects., Zhang X, Marjani SL, Hu Z, Weissman SM, Pan X, Wu S., 2016
A Molecular Chipper Technology for CRISPR sgRNA Library Generation and Functional Mapping of Noncoding Regions., Cheng J, Roden C, Pan W, Zhu S, Baccei A, Pan X, Jiang T, Kluger Y, Weissman S, Guo S, Flavell R, Ding Y, Lu J., 2016
Regulation of the DNA Methylation Landscape in Human Somatic Cell Reprogramming by the miR-29 Family., Hysolli E, Tanaka Y, Su J, Kim KY, Zhong T, Janknecht R, Zhou XL, Geng L, Qiu C, Pan X, Jung YW, Cheng J, Lu J, Zhong M, Weissman SM, Park IH., 2016
Th17 cells transdifferentiation into regulatory T cells during resolution of inflammation., Gagliani N, Vesely MC, Iseppon A, Brockmann L, Xu H, Palm NW, de Zoete MR, Licona-Limón P, Paiva RS, Ching T, Weaver C, Zi X, Pan X, Fan R, Garmire LX, Cotton MJ, Drier Y, Bernstein B, Geginat J, Stockinger B, Esplugues E, Huber S, Flavell RA., 2015
Transcriptome Signature and Regulation in Human Somatic Cell Reprogramming., Tanaka Y, Hysolli E, Su J, Xiang Y, Kim KY, Zhong M, Li Y, Heydari K, Euskirchen G, Snyder MP, Pan X, Weissman SM, Park IH., 2015
X chromosome of female cells shows dynamic changes in status during human somatic cell reprogramming., Kim KY, Hysolli E, Tanaka Y, Wang B, Jung YW, Pan X, Weissman SM, Park IH., 2014
Single-cell analysis of the transcriptome and its application in the characterization of stem cells and early embryos., Liu N, Liu L, Pan X., 2014
Non-stochastic reprogramming from a privileged somatic cell state., Guo S, Zi X, Schultz V, Cheng J, Zhong M, Koochaki S, Megyola CM, Pan X, Heydari K, Weissman SM, Gallagher PG, Krause DS, Fan R, Lu J., 2014
Co-detection and sequencing of genes and transcripts from the same single cells enabled by a microfluidics platform., Han L, Zi X, Garmire LX, Wu Y, Weissman SM, Pan X, Fan R., 2014
Single Cell Analysis: From Technology to Biology and Medicine., Xinghua Pan., 2014
Robust measurement of telomere length in single cells., Wang F, Pan X, Kalmbach K, Seth-Smith ML, Ye X, Antumes DM, Yin Y, Liu L, Keefe DL, Weissman SM., 2013
Transcriptome regulation in pluripotent stem cells by methyl CpG-binding protein 2 (MeCP2)., Tanaka Y, Kim KY, Zhong M, Pan X, Weissman SM, Park I-H., 2014
Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing., Dan J, Liu Y, Liu N, Chiourea M, Okuka M, Wu T, Ye X, Mou C, Wang L, Wang L, Yin Y, Yuan J, Zuo B, Wang F, Li Z, Pan X, Yin Z, Chen L, Keefe DL, Gagos S, Xiao A, Liu L., 2014
Two methods for full-length RNA sequencing for low quantities of cells and single cells., Pan X, Durrett RE, Zhu H, Tanaka Y, Li Y, Zi X, Marjani SL, Euskirchen G, Ma C, Lamotte RH, Park IH, Snyder MP, Mason CE, Weissman SM., 2013
Functional genomic screen of human stem cell differentiation reveals pathways involved in neurodevelopment and neurodegeneration., Zhang Y, Schulz V, Reed B, Wang Z, Pan X, Mariani J, Euskirchenc G, Snyder M, Vaccarino FM, Ivanova N, Weissman SM, Szekely AM., 2013
Cuprous oxide nanoparticles inhibit the growth and metastasis of melanoma by targeting mitochondria., Wang Y, Yang F, Zhang HX, Zi XY, Pan XH, Chen F, Luo WD, Li JX, Zhu HY, Hu YP., 2013
Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells (iPSCs)., Wang F, Yin Y, Ye Xiaoying, Liu K, Zhu H, Wang L, Chiourea M, Okuka M, Jia G, Dan, J, Zuo B, Li M, Zhang Q, Liu N, Chen L, Pan X, Gagos S, Keefee D, Lin L., 2012
Germline competency of parthenogenetic embryonic stem cells from immature oocytes of adult mouse ovary., Liu Z, Hu Z, Pan X, Li M, Togun TA, Tuck D, Pelizzola M, Huang J, Ye X, Yin Y, Liu M, Li C, Chen Z, Wang F, Zhou L, Chen L, Keefe DL, Liu L., 2011
X chromosome-wide analyses of genomic DNA methylation states and gene expression in male and female neutrophils., Yasukochia Y, Maruyamab O, Mahajana MC, Paddenc C, Euskirchend GM, Schulze V, Hirakawaf H, Kuharag S, Pan XH, Newburgerc PE, Snyder M, Weissmana SM., 2010
A procedure for highly specific, hypersensitive and unbiased whole genome amplification., Pan X, Urban AE, Dean P, Vincent S, Grubbert F, Hu Y, Snyder M, Weissman SM., 2008
Murine fertilized ovum, blastomere and morula cells lacking SP phenotype., Xu Y, He Z, Zhu H, Chen X, Li J, Zhang H, Pan X, Hu Y., 2007
An approach for global scanning of single nucleotide variations., Pan X, Weissman SM., 2002
Molecular evolution of MHC-DQA genes: I. The maintenance of interallelic divergence and the influence of GC content on gene structure., Pan X, Fu J., 1997
Molecular evolution of MHC-DQA genes: II. Phylogenetic analysis based on nucleotide substitution and synonymous codon usage bias., Pan X, Fu J., 1997
Research on the genetic susceptibility for Myasthenia Gravis in Chinese Hans by genotyping of HLA-DQA1 with PCR-RFLP., Pan X, Lu J, Inoko H, Tan CC, Geng Z, Zhang R, Tu L, Jiang J., 1995
Cytogenetics studies of two Calyptrate Dipteras (Sarcophagidae and Calliphoridae: Diptera)., Pan X, He L., 1991
Keywords
Single CellTechnologyInnovationCancerHeterogeneityBiomarkerGenomeMedicineBioinformaticsStem Cell
Area of Focus
Bioinformatics | Mirna | Lncrna | Computational Biology | Disease Analysis | Data Mining | Rna | Drug Development | Cardiovascular Diseases | Cancer
Area of Focus
Multi-Omics | Statistics | Data Analysis | Cancer | Genomics | Bioinformatics | Computational Biology | Research | Development | Application
Area of Focus
Genome Bioinformatics | Ngs | Molecular Subtype | Big Data | Gene Expression | Dna Methylation | Cancer | Genomics | Bioinformatics | Precision Medicine
