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Shanshan Ai
Basic Medical Sciences
Southern Medical University
Guangdong
Language: Chinese, English
Cell Fate
Single-Cell Chip-Seq
Embryo Development
Epigenetic Regulation
Cardiac Development
Regeneration
Multi-Omics
Sequencing
Technology Development
Epigenetics
Areas of Focus
- Epigenetic regulation mechanisms in cardiac development and regeneration
- Development of new single-cell multi-omics sequencing technologies
Work Experience
- 2020-Present - Southern Medical University - Physiology Department
Academic Background & Achievements
- 2020 - PhD: Peking University
- Developed two universal single-cell ChIP-seq technologies: itChIP-seq and CoBATCH
Publications
- Profiling chromatin states using single-cell itchip-seq, Ai S, Xiong H, Li CC, Luo Y, Shi Q, Liu Y, Yu X, Li C, He A, 2019
- Cobatch for high-throughput single-cell epigenomic profiling, Wang Q, Xiong H, Ai S, Yu X, Liu Y, Zhang J, He A, 2019
- Replication-independent histone turnover underlines the epigenetic homeostasis in adult heart, Li Y, Ai S, Yu X, Li C, Li X, Yue Y, Wei Y, Li CY, He A, 2019
- Divergent requirements for ezh1 in heart development versus regeneration, Ai S, Yu X, Li Y, Peng Y, Li C, Yue Y, Tao G, Li C, Pu WT, He A, 2017
- Eed orchestration of heart maturation through interaction with hdacs is h3k27me3-independent, Ai S, Peng Y, Li C, Gu F, Yu X, Yue Y, Ma Q, Chen J, Lin Z, Zhou P, Xie H, Prendiville TW, Zheng W, Liu Y, Orkin SH, Wang DZ, Yu J, Pu WT, He A, 2017
- Single-cell transcriptomics reveals chemotaxis mediated intra-organ crosstalk during cardiogenesis, Xiong H, Luo Y, Yue Y, Zhang J, Ai S, Li X, Wang X, Zhang YL, Wei Y, Li H, Hu X, Li C, He A, 2019
- The lncrna hand2os1/uph locus orchestrates heart development through regulation of precise expression of hand2, Han X, Zhang JJ, Liu YX, Fan XY, Ai S, Luo YJ, Li X, Jin HW, Luo S, Zheng H, Yue YZ, Chang Z, Yang ZZ, Tang FC, He AB, Shen XH, 2019
- Mouse knockout models reveal largely dispensable but context-dependent functions of lncrnas during development, Han X, Luo S, Peng G, Lu JY, Cui G, Liu L, Yan P, Yin Y, Liu W, Wang R, Zhang J, Ai S, Chang Z, Na J, He A, Jing N, Shen X, 2018
