Professor | Wen Bo | Asia Growth Partners

Name	Wen Bo
Contact Information	bowen75@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

Name

Wen Bo

Contact Information

bowen75@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Basic Medical Sciences
Academic Background & Achievements	1993.09—1997.06 Bachelor's Degree: Yunnan University, Department of Biology 1997.09—2000.06 Master's Degree: Yunnan University, Department of Biology 2000.09—2004.01 PhD: Fudan University, Genetics
Work Experience	2005.04—2009.03 - Johns Hopkins University - Postdoctoral Researcher 2009.04—2010.06 - Johns Hopkins University - Lecturer 2010.07—2017.02 - Fudan University, Institute of Biomedical Sciences - Researcher 2010.07—Present - Fudan University, School of Basic Medical Sciences - Researcher
Awards	2012: Outstanding Young Talent in Shanghai Health System, Shanghai Health Commission 2011: Pujiang Talent, Shanghai Science and Technology Commission 2010: Dawn Scholar, Shanghai Education Commission 2006: National Excellent Doctoral Dissertation, Ministry of Education 2005: First Prize in Natural Science of Yunnan Province, Yunnan Provincial Government

University/Lab Affiliation and Title

Fudan University

Faculty

Basic Medical Sciences

Academic Background & Achievements

1993.09—1997.06 Bachelor's Degree: Yunnan University, Department of Biology
1997.09—2000.06 Master's Degree: Yunnan University, Department of Biology
2000.09—2004.01 PhD: Fudan University, Genetics

Work Experience

2005.04—2009.03 - Johns Hopkins University - Postdoctoral Researcher
2009.04—2010.06 - Johns Hopkins University - Lecturer
2010.07—2017.02 - Fudan University, Institute of Biomedical Sciences - Researcher
2010.07—Present - Fudan University, School of Basic Medical Sciences - Researcher

Awards

2012: Outstanding Young Talent in Shanghai Health System, Shanghai Health Commission
2011: Pujiang Talent, Shanghai Science and Technology Commission
2010: Dawn Scholar, Shanghai Education Commission
2006: National Excellent Doctoral Dissertation, Ministry of Education
2005: First Prize in Natural Science of Yunnan Province, Yunnan Provincial Government

Areas of Focus	Physiological functions, pathological significance, formation and maintenance mechanisms of higher-order chromatin structure Epigenetic mechanisms of cell fate transformation
Publications	The Nuclear Matrix Protein SAFB Cooperates with Major Satellite RNAs to Stabilize Heterochromatin Architecture Partially through Phase Separation, Huo X, Ji L, Zhang Y, Lv P, Cao X, Wang Q, Yan Z, Dong S, Du D, Zhang F, Wei G, Liu Y, Wen B, 2020 The nuclear matrix protein HNRNPU maintains 3D genome architecture globally in mouse hepatocytes, Fan H#, Lv P#, Huo X, Wu J, Wang Q, Cheng L, Liu Y, Tang QQ, Zhang L, Zhang F, Zheng X, Wu H, Wen B, 2018 The nuclear bodies formed by histone demethylase KDM7A, Ming H#, Wang Q#, Zhang Y, Ji L, Cheng L, Huo X, Yan Z, Dang Y and Wen B, 2021 G9a/GLP-Sensitivity of H3K9me2 Demarcates Two Types of Genomic Compartments, Yan Z#, Ji L,Huo X#, Wang Q, Zhang Y, Wen B, 2020 The Long Noncoding RNA Lncenc1 Maintains Naive States of Mouse ESCs by Promoting the Glycolysis Pathway, Sun Z#, Zhu M#, Lv P, Cheng L, Wang Q, Tian P, Yan Z, Wen B, 2018 Disruption of nuclear speckles reduces chromatin interactions in active compartments, Hu S#, Lv P#, Yan Z, Wen B, 2019 A long non-coding RNA specifically expressed in early embryos programs the metabolic balance in adult mice, Zhu M, Wang Q, Tian P, Cheng L, Sun Z, Hong Q, Lv P, Ji L, Liu Y, Tang QQ, Wen B, 2020 Large histone H3 lysine-9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells, Wen B, Wu H, Shinkai Y, Irizarry R and Feinberg AP, 2009 Differential methylation of tissue- and cancer specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts, Doi A#, Park IH#, Wen B#, Murakami P, Aryee M, Irizarry R, Herb B, Ladd-Acosta C, Rho J, Loewer S, Miller J, Schlaeger T, Daley GQ and Feinberg AP, 2009 Genetic Evidence Supports Demic Diffusion of Han Culture, Wen B, Li H, Lu DR, Song XF, Zhang F, He YG, Li F, Gao Y, Mao XY, Zhang L, Qian J, Tan JZ, Huang W, Deka R, Su B, Chakraborty R, Jin L, 2004

Areas of Focus

Physiological functions, pathological significance, formation and maintenance mechanisms of higher-order chromatin structure
Epigenetic mechanisms of cell fate transformation

Publications

The Nuclear Matrix Protein SAFB Cooperates with Major Satellite RNAs to Stabilize Heterochromatin Architecture Partially through Phase Separation, Huo X, Ji L, Zhang Y, Lv P, Cao X, Wang Q, Yan Z, Dong S, Du D, Zhang F, Wei G, Liu Y, Wen B*, 2020
The nuclear matrix protein HNRNPU maintains 3D genome architecture globally in mouse hepatocytes, Fan H#, Lv P#, Huo X, Wu J, Wang Q, Cheng L, Liu Y, Tang QQ, Zhang L, Zhang F, Zheng X, Wu H, Wen B*, 2018
The nuclear bodies formed by histone demethylase KDM7A, Ming H#, Wang Q#, Zhang Y, Ji L, Cheng L, Huo X, Yan Z, Dang Y and Wen B*, 2021
G9a/GLP-Sensitivity of H3K9me2 Demarcates Two Types of Genomic Compartments, Yan Z#, Ji L,Huo X#, Wang Q, Zhang Y, Wen B*, 2020
The Long Noncoding RNA Lncenc1 Maintains Naive States of Mouse ESCs by Promoting the Glycolysis Pathway, Sun Z#, Zhu M#, Lv P, Cheng L, Wang Q, Tian P, Yan Z, Wen B*, 2018
Disruption of nuclear speckles reduces chromatin interactions in active compartments, Hu S#, Lv P#, Yan Z, Wen B*, 2019
A long non-coding RNA specifically expressed in early embryos programs the metabolic balance in adult mice, Zhu M, Wang Q, Tian P, Cheng L, Sun Z, Hong Q, Lv P, Ji L, Liu Y, Tang QQ, Wen B*, 2020
Large histone H3 lysine-9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells, Wen B, Wu H, Shinkai Y, Irizarry R and Feinberg AP*, 2009
Differential methylation of tissue- and cancer specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts, Doi A#, Park IH#, Wen B#, Murakami P, Aryee M, Irizarry R, Herb B, Ladd-Acosta C, Rho J, Loewer S, Miller J, Schlaeger T, Daley GQ and Feinberg AP*, 2009
Genetic Evidence Supports Demic Diffusion of Han Culture, Wen B, Li H, Lu DR, Song XF, Zhang F, He YG, Li F, Gao Y, Mao XY, Zhang L, Qian J, Tan JZ, Huang W, Deka R, Su B, Chakraborty R, Jin L*, 2004

Chromatin Structure Physiology Pathology Formation Maintenance Epigenetics Cell Fate Transformation Mechanisms

Hua Wang - Peking University

Shanshan Ai - Southern Medical University

Luyang Sun - Peking University

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