Areas of Focus
- Physiological functions, pathological significance, formation and maintenance mechanisms of higher-order chromatin structure
- Epigenetic mechanisms of cell fate transformation
Work Experience
- 2005.04—2009.03 - Johns Hopkins University - Postdoctoral Researcher
- 2009.04—2010.06 - Johns Hopkins University - Lecturer
- 2010.07—2017.02 - Fudan University, Institute of Biomedical Sciences - Researcher
- 2010.07—Present - Fudan University, School of Basic Medical Sciences - Researcher
Academic Background & Achievements
- 1993.09—1997.06 Bachelor's Degree: Yunnan University, Department of Biology
- 1997.09—2000.06 Master's Degree: Yunnan University, Department of Biology
- 2000.09—2004.01 PhD: Fudan University, Genetics
Publications
- The Nuclear Matrix Protein SAFB Cooperates with Major Satellite RNAs to Stabilize Heterochromatin Architecture Partially through Phase Separation, Huo X, Ji L, Zhang Y, Lv P, Cao X, Wang Q, Yan Z, Dong S, Du D, Zhang F, Wei G, Liu Y, Wen B*, 2020
- The nuclear matrix protein HNRNPU maintains 3D genome architecture globally in mouse hepatocytes, Fan H#, Lv P#, Huo X, Wu J, Wang Q, Cheng L, Liu Y, Tang QQ, Zhang L, Zhang F, Zheng X, Wu H, Wen B*, 2018
- The nuclear bodies formed by histone demethylase KDM7A, Ming H#, Wang Q#, Zhang Y, Ji L, Cheng L, Huo X, Yan Z, Dang Y and Wen B*, 2021
- G9a/GLP-Sensitivity of H3K9me2 Demarcates Two Types of Genomic Compartments, Yan Z#, Ji L,Huo X#, Wang Q, Zhang Y, Wen B*, 2020
- The Long Noncoding RNA Lncenc1 Maintains Naive States of Mouse ESCs by Promoting the Glycolysis Pathway, Sun Z#, Zhu M#, Lv P, Cheng L, Wang Q, Tian P, Yan Z, Wen B*, 2018
- Disruption of nuclear speckles reduces chromatin interactions in active compartments, Hu S#, Lv P#, Yan Z, Wen B*, 2019
- A long non-coding RNA specifically expressed in early embryos programs the metabolic balance in adult mice, Zhu M, Wang Q, Tian P, Cheng L, Sun Z, Hong Q, Lv P, Ji L, Liu Y, Tang QQ, Wen B*, 2020
- Large histone H3 lysine-9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells, Wen B, Wu H, Shinkai Y, Irizarry R and Feinberg AP*, 2009
- Differential methylation of tissue- and cancer specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts, Doi A#, Park IH#, Wen B#, Murakami P, Aryee M, Irizarry R, Herb B, Ladd-Acosta C, Rho J, Loewer S, Miller J, Schlaeger T, Daley GQ and Feinberg AP*, 2009
- Genetic Evidence Supports Demic Diffusion of Han Culture, Wen B, Li H, Lu DR, Song XF, Zhang F, He YG, Li F, Gao Y, Mao XY, Zhang L, Qian J, Tan JZ, Huang W, Deka R, Su B, Chakraborty R, Jin L*, 2004
Awards
- 2012: Outstanding Young Talent in Shanghai Health System, Shanghai Health Commission
- 2011: Pujiang Talent, Shanghai Science and Technology Commission
- 2010: Dawn Scholar, Shanghai Education Commission
- 2006: National Excellent Doctoral Dissertation, Ministry of Education
- 2005: First Prize in Natural Science of Yunnan Province, Yunnan Provincial Government
