Professor | Aidong Zhou | Asia Growth Partners

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Name	Aidong Zhou
Contact Information	aidern0927@smu.edu.cn
Language ability	English, Chinese
Province	Guangdong

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Name

Aidong Zhou

Contact Information

aidern0927@smu.edu.cn

Language ability

English, Chinese

Province

Guangdong

University/Lab Affiliation and Title	Southern Medical University
Faculty	Basic Medical Sciences
Academic Background & Achievements	2011 - PhD in Biochemistry and Molecular Biology: Sun Yat-sen University Published over 20 research papers in renowned journals
Work Experience	2011-2018 - University of Texas MD Anderson Cancer Center - Postdoctoral Researcher and Lecturer 2018-present - Southern Medical University - Professor
Awards	2019: Guangdong Province Talent Program High-Level Talent Introduction 2017: Caroline Rose Fellowship Award, MD Anderson Cancer Center

University/Lab Affiliation and Title

Southern Medical University

Faculty

Basic Medical Sciences

Academic Background & Achievements

2011 - PhD in Biochemistry and Molecular Biology: Sun Yat-sen University
Published over 20 research papers in renowned journals

Work Experience

2011-2018 - University of Texas MD Anderson Cancer Center - Postdoctoral Researcher and Lecturer
2018-present - Southern Medical University - Professor

Awards

2019: Guangdong Province Talent Program High-Level Talent Introduction
2017: Caroline Rose Fellowship Award, MD Anderson Cancer Center

Areas of Focus	Cellular and molecular basis of glioblastoma multiforme radio/chemotherapy resistance Tumor microenvironment and tumor cell response mechanisms in glioblastoma Molecular mechanisms of lung cancer brain metastasis and development of new intervention drugs
Publications	Aberrant Activation of β-Catenin Signaling Drives Glioma Tumorigenesis via USP1-Mediated Stabilization of EZH2, Li Ma, Kangyu Lin, Guoqiang Chang, Chen Yue, Qing Guo, Sicong Zhang, Yiwen Chen, Tony T. Huang, Aidong Zhou, Suyun Huang, 2019 Targeting Protein Kinases for the Treatment of Glioblastoma Multiforme: Linking Basic Studies to Clinical Applications, Aidong Zhou, 2017 Gli1-induced deubiquitinase USP48 aids glioblastoma tumorigenesis by stabilizing Gli1, Aidong Zhou, Kangyu Lin, Sicong Zhang, Li Ma, Jianfei Xue, Saint-Aaron Morris, Kenneth D Aldape, Suyun Huang, 2017 A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program, Sicong Zhang, Boxuan Zhao, Aidong Zhou, Kangyu Lin, Shaoping Zheng, Zhike Lu, Yaohui Chen, Erik P. Sulman, Keping Xie, Oliver Bogler, Sadhan Majumder, Chuan He, Suyun Huang, 2017 Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22, Aidong Zhou, Kangyu Lin, Sicong Zhang, Yaohui Chen, Nu Zhang, Jianfei Xue, Zhongyong Wang, Kenneth D. Aldape, Keping Xie, James R. Woodgett, Suyun Huang, 2016 Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22, Jianfei Xue, Aidong Zhou, Yamei Wu, Saint-Aaron Morris, Kangyu Lin, Samirkumar Amin, Roeland Verhaak, Gregory Fuller, Keping Xie, Amy B. Heimberger, Suyun Huang, 2016 β-catenin/LEF1 transactivates the microRNA-371-373 cluster that modulates the Wnt/β-catenin signaling pathway, Aidong Zhou, Li-Ting Diao, Hui Xu, Zhen-Dong Xiao, Jun-Hao Li, Hui Zhou, Liang-Hu Qu, 2012 Tumour suppressor TRIM33 targets nuclear β-catenin degradation, Jianfei Xue, Yaohui Chen, Yamei Wu, Zhongyong Wang, Aidong Zhou, Sicong Zhang, Kangyu Lin, Kenneth Aldape, Sadhan Majumder, Zhimin Lu, Suyun Huang, 2015 Wnt-Induced Deubiquitination of FoxM1 Ensures Nucleus β-catenin Transactivation, Chen Y, Yu Li, Xue J, Gong A, Yu G, Aidong Zhou, et al., 2016 Forkhead Box M1 Is Essential for Nuclear Localization of Glioma-associated Oncogene Homolog 1 in Glioblastoma Multiforme Cells by Promoting Importin-7 Expression, Xue J, Aidong Zhou, Tan C, Wu Y, Lee HT, Li W, Xie K, Huang S, 2015

Areas of Focus

Cellular and molecular basis of glioblastoma multiforme radio/chemotherapy resistance
Tumor microenvironment and tumor cell response mechanisms in glioblastoma
Molecular mechanisms of lung cancer brain metastasis and development of new intervention drugs

Publications

Aberrant Activation of β-Catenin Signaling Drives Glioma Tumorigenesis via USP1-Mediated Stabilization of EZH2, Li Ma, Kangyu Lin, Guoqiang Chang, Chen Yue, Qing Guo, Sicong Zhang, Yiwen Chen, Tony T. Huang, Aidong Zhou, Suyun Huang, 2019
Targeting Protein Kinases for the Treatment of Glioblastoma Multiforme: Linking Basic Studies to Clinical Applications, Aidong Zhou, 2017
Gli1-induced deubiquitinase USP48 aids glioblastoma tumorigenesis by stabilizing Gli1, Aidong Zhou, Kangyu Lin, Sicong Zhang, Li Ma, Jianfei Xue, Saint-Aaron Morris, Kenneth D Aldape, Suyun Huang, 2017
A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program, Sicong Zhang, Boxuan Zhao, Aidong Zhou, Kangyu Lin, Shaoping Zheng, Zhike Lu, Yaohui Chen, Erik P. Sulman, Keping Xie, Oliver Bogler, Sadhan Majumder, Chuan He, Suyun Huang, 2017
Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22, Aidong Zhou, Kangyu Lin, Sicong Zhang, Yaohui Chen, Nu Zhang, Jianfei Xue, Zhongyong Wang, Kenneth D. Aldape, Keping Xie, James R. Woodgett, Suyun Huang, 2016
Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22, Jianfei Xue, Aidong Zhou, Yamei Wu, Saint-Aaron Morris, Kangyu Lin, Samirkumar Amin, Roeland Verhaak, Gregory Fuller, Keping Xie, Amy B. Heimberger, Suyun Huang, 2016
β-catenin/LEF1 transactivates the microRNA-371-373 cluster that modulates the Wnt/β-catenin signaling pathway, Aidong Zhou, Li-Ting Diao, Hui Xu, Zhen-Dong Xiao, Jun-Hao Li, Hui Zhou, Liang-Hu Qu, 2012
Tumour suppressor TRIM33 targets nuclear β-catenin degradation, Jianfei Xue, Yaohui Chen, Yamei Wu, Zhongyong Wang, Aidong Zhou, Sicong Zhang, Kangyu Lin, Kenneth Aldape, Sadhan Majumder, Zhimin Lu, Suyun Huang, 2015
Wnt-Induced Deubiquitination of FoxM1 Ensures Nucleus β-catenin Transactivation, Chen Y, Yu Li, Xue J, Gong A, Yu G, Aidong Zhou, et al., 2016
Forkhead Box M1 Is Essential for Nuclear Localization of Glioma-associated Oncogene Homolog 1 in Glioblastoma Multiforme Cells by Promoting Importin-7 Expression, Xue J, Aidong Zhou, Tan C, Wu Y, Lee HT, Li W, Xie K, Huang S, 2015

Glioblastoma Tumor Microenvironment Chemoresistance Brain Metastasis Molecular Mechanisms Intervention Drugs Cellular Basis Radio/Chemotherapy Tumorigenesis Microenvironment

Ze-Fen Wang - Wuhan University

Luqing Zhao - Central South University

Chen She - Fudan University

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