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周爱冬
Basic Medical Sciences
南方医科大学
广东
Language: 英语, 中文
胶质母细胞瘤
肿瘤微环境
耐药
脑转移
分子机制
干预药物
细胞基础
放/化疗
肿瘤发生
微环境
Areas of Focus
- 胶质母细胞瘤放/化疗耐药的细胞和分子基础
- 肿瘤微环境与肿瘤细胞应答机制在胶质母细胞瘤中的作用
- 肺癌脑转移的分子机制及新型干预药物的开发
Work Experience
- 2011-2018 - 德克萨斯大学MD安德森癌症中心 - 博士后和讲师
- 2018至今 - 南方医科大学 - 教授
Academic Background & Achievements
- 2011 - 生化与分子生物学博士: 中山大学
- 在著名杂志上发表了20余篇研究论文
Publications
- Aberrant Activation of β-Catenin Signaling Drives Glioma Tumorigenesis via USP1-Mediated Stabilization of EZH2, Li Ma, Kangyu Lin, Guoqiang Chang, Chen Yue, Qing Guo, Sicong Zhang, Yiwen Chen, Tony T. Huang, Aidong Zhou, Suyun Huang, 2019
- Targeting Protein Kinases for the Treatment of Glioblastoma Multiforme: Linking Basic Studies to Clinical Applications, Aidong Zhou, 2017
- Gli1-induced deubiquitinase USP48 aids glioblastoma tumorigenesis by stabilizing Gli1, Aidong Zhou, Kangyu Lin, Sicong Zhang, Li Ma, Jianfei Xue, Saint-Aaron Morris, Kenneth D Aldape, Suyun Huang, 2017
- A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program, Sicong Zhang, Boxuan Zhao, Aidong Zhou, Kangyu Lin, Shaoping Zheng, Zhike Lu, Yaohui Chen, Erik P. Sulman, Keping Xie, Oliver Bogler, Sadhan Majumder, Chuan He, Suyun Huang, 2017
- Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22, Aidong Zhou, Kangyu Lin, Sicong Zhang, Yaohui Chen, Nu Zhang, Jianfei Xue, Zhongyong Wang, Kenneth D. Aldape, Keping Xie, James R. Woodgett, Suyun Huang, 2016
- Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22, Jianfei Xue, Aidong Zhou, Yamei Wu, Saint-Aaron Morris, Kangyu Lin, Samirkumar Amin, Roeland Verhaak, Gregory Fuller, Keping Xie, Amy B. Heimberger, Suyun Huang, 2016
- β-catenin/LEF1 transactivates the microRNA-371-373 cluster that modulates the Wnt/β-catenin signaling pathway, Aidong Zhou, Li-Ting Diao, Hui Xu, Zhen-Dong Xiao, Jun-Hao Li, Hui Zhou, Liang-Hu Qu, 2012
- Tumour suppressor TRIM33 targets nuclear β-catenin degradation, Jianfei Xue, Yaohui Chen, Yamei Wu, Zhongyong Wang, Aidong Zhou, Sicong Zhang, Kangyu Lin, Kenneth Aldape, Sadhan Majumder, Zhimin Lu, Suyun Huang, 2015
- Wnt-Induced Deubiquitination of FoxM1 Ensures Nucleus β-catenin Transactivation, Chen Y, Yu Li, Xue J, Gong A, Yu G, Aidong Zhou, et al., 2016
- Forkhead Box M1 Is Essential for Nuclear Localization of Glioma-associated Oncogene Homolog 1 in Glioblastoma Multiforme Cells by Promoting Importin-7 Expression, Xue J, Aidong Zhou, Tan C, Wu Y, Lee HT, Li W, Xie K, Huang S, 2015
Awards
- 2019: 广东省人才计划高层引进人才
- 2017: Caroline Rose Fellowship Award, MD安德森癌症中心
