Professor | Wen Liu | Asia Growth Partners

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Name	Wen Liu
Contact Information	liuwen@nju.edu.cn
Language ability	Chinese, English
Province	Jiangsu

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Name

Wen Liu

Contact Information

liuwen@nju.edu.cn

Language ability

Chinese, English

Province

Jiangsu

University/Lab Affiliation and Title	Nanjing University
Faculty	Life Sciences
Academic Background & Achievements	2006.9-2010.6 Bachelor's in Biochemistry: Nanjing University 2010.9-2013.6 Master's in Pharmaceutical Engineering: Nanjing University 2013.9-2016.6 PhD in Pharmacology: Nanjing University
Work Experience	2016.7-2018.12 - Nanjing University - Postdoctoral Researcher 2019.1-2023.02 - Nanjing University - Associate Researcher 2023.3-Present - Nanjing University - Assistant Professor / Distinguished Researcher

University/Lab Affiliation and Title

Nanjing University

Faculty

Life Sciences

Academic Background & Achievements

2006.9-2010.6 Bachelor's in Biochemistry: Nanjing University
2010.9-2013.6 Master's in Pharmaceutical Engineering: Nanjing University
2013.9-2016.6 PhD in Pharmacology: Nanjing University

Work Experience

2016.7-2018.12 - Nanjing University - Postdoctoral Researcher
2019.1-2023.02 - Nanjing University - Associate Researcher
2023.3-Present - Nanjing University - Assistant Professor / Distinguished Researcher

Areas of Focus	Coagulation and Inflammation
Publications	Spirodalesol analog 8A inhibits NLRP3 inflammasome activation and attenuates inflammatory disease by directly targeting adaptor protein ASC., Wen Liu, Jiashu Yang, Shihao Fang, Chenyang Jiao, Jianhua Gao, Aihua Zhang, Tiancong Wu, Renxiang Tan, Qiang Xu, Wenjie Guo, 2022 Apo-form selective inhibition of indoleamine-2,3-dioxygenase for tumor immunotherapy., Liu Wen, Zou Yi, Li Kaiming, Zhong Haiqing, Yu Longbo, Ge Shushan, Lai Yisheng, Xianchi Dong, Xu Qiang, Guo Wenjie, 2022 SHP2-mediated mitophagy boosted by lovastatin in neuronal cells alleviates parkinsonism in mice., Wen Liu, Meijing Wang, Lihong Shen, Yuyu Zhu, Hongyue Ma, Bo Liu, Liang Ouyang, Wenjie Guo, Qiang Xu, Yang Sun, 2021 SHP2-mediated inhibition of DNA repair contributes to cGAS-STING activation and chemotherapeutic sensitivity in colon cancer., Bin Wei, Lingyan Xu, Wenjie Guo, Yuanyuan Wang, Jingjing Wu, Xiaofei Li, Xiaomin Cai, Jinbo Hu, Meijing Wang, Qiang Xu, Wen Liu, Yanhong Gu, 2021 DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS‒STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis., Yuanyuan Wang, Bin Wei, Danping Wang, Jingjing Wu, Jianhua Gao, Haiqing Zhong, Yang Sun, Qiang Xu, Wen Liu, Yanhong Gu, Wenjie Guo, 2021 Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet–induced hepatic steatosis and insulin resistance by elevating IL-18 levels., Wen Liu, Ye Yin, Meijing Wang, Ting Fan, Yuyu Zhu, Lihong Shen, Shuang Peng, Jian Gao, Guoliang Deng, Xiangbao Meng, Lingdong Kong, Gensheng Feng, Wenjie Guo, Qiang Xu, Yang Sun, 2020 Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis., Wenjie Guo, Wen Liu, Z Chen, Y Gu, S Peng, L Shen, Y Shen, X Wang, GS Feng, Y Sun, Q Xu, 2017

Areas of Focus

Coagulation and Inflammation

Publications

Spirodalesol analog 8A inhibits NLRP3 inflammasome activation and attenuates inflammatory disease by directly targeting adaptor protein ASC., Wen Liu, Jiashu Yang, Shihao Fang, Chenyang Jiao, Jianhua Gao, Aihua Zhang, Tiancong Wu, Renxiang Tan, Qiang Xu, Wenjie Guo, 2022
Apo-form selective inhibition of indoleamine-2,3-dioxygenase for tumor immunotherapy., Liu Wen, Zou Yi, Li Kaiming, Zhong Haiqing, Yu Longbo, Ge Shushan, Lai Yisheng, Xianchi Dong, Xu Qiang, Guo Wenjie, 2022
SHP2-mediated mitophagy boosted by lovastatin in neuronal cells alleviates parkinsonism in mice., Wen Liu, Meijing Wang, Lihong Shen, Yuyu Zhu, Hongyue Ma, Bo Liu, Liang Ouyang, Wenjie Guo, Qiang Xu, Yang Sun, 2021
SHP2-mediated inhibition of DNA repair contributes to cGAS-STING activation and chemotherapeutic sensitivity in colon cancer., Bin Wei, Lingyan Xu, Wenjie Guo, Yuanyuan Wang, Jingjing Wu, Xiaofei Li, Xiaomin Cai, Jinbo Hu, Meijing Wang, Qiang Xu, Wen Liu, Yanhong Gu, 2021
DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS‒STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis., Yuanyuan Wang, Bin Wei, Danping Wang, Jingjing Wu, Jianhua Gao, Haiqing Zhong, Yang Sun, Qiang Xu, Wen Liu, Yanhong Gu, Wenjie Guo, 2021
Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet–induced hepatic steatosis and insulin resistance by elevating IL-18 levels., Wen Liu, Ye Yin, Meijing Wang, Ting Fan, Yuyu Zhu, Lihong Shen, Shuang Peng, Jian Gao, Guoliang Deng, Xiangbao Meng, Lingdong Kong, Gensheng Feng, Wenjie Guo, Qiang Xu, Yang Sun, 2020
Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis., Wenjie Guo, Wen Liu, Z Chen, Y Gu, S Peng, L Shen, Y Shen, X Wang, GS Feng, Y Sun, Q Xu, 2017

Coagulation Inflammation Molecular Biology Chemical Biology Pharmacology Omics Structural Biology Regulatory Factors Drug Targets Therapeutic Candidates

Yihua Chen - East China Normal University

Li Ruixi - Southern University of Science and Technology

Yihua Chen - East China Normal University

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