Areas of Focus
- 凝血与炎症
Work Experience
- 2016.7-2018.12 - 南京大学 - 博士后
- 2019.1-2023.02 - 南京大学 - 副研究员
- 2023.3-至今 - 南京大学 - 助理教授/特聘研究员
Academic Background & Achievements
- 2006.9-2010.6 生物化学学士: 南京大学
- 2010.9-2013.6 制药工程硕士: 南京大学
- 2013.9-2016.6 药理学博士: 南京大学
Publications
- Spirodalesol analog 8A inhibits NLRP3 inflammasome activation and attenuates inflammatory disease by directly targeting adaptor protein ASC., 刘雯, 杨佳树, 方世豪, 焦晨阳, 高建华, 张爱华, 吴天聪, 谭仁祥, 徐强, 郭文杰, 2022
- Apo-form selective inhibition of indoleamine-2,3-dioxygenase for tumor immunotherapy., 刘雯, 邹毅, 李开明, 钟海清, 余龙波, 葛舒珊, 赖义生, 董显驰, 徐强, 郭文杰, 2022
- SHP2-mediated mitophagy boosted by lovastatin in neuronal cells alleviates parkinsonism in mice., 刘雯, 王美静, 沈丽红, 朱玉玉, 马红月, 刘波, 欧阳亮, 郭文杰, 徐强, 孙阳, 2021
- SHP2-mediated inhibition of DNA repair contributes to cGAS-STING activation and chemotherapeutic sensitivity in colon cancer., 魏斌, 徐凌燕, 郭文杰, 王媛媛, 吴晶晶, 李晓飞, 蔡晓敏, 胡金波, 王美静, 徐强, 刘雯, 顾艳红, 2021
- DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS‒STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis., 王媛媛, 魏斌, 王丹萍, 吴晶晶, 高建华, 钟海清, 孙阳, 徐强, 刘雯, 顾艳红, 郭文杰, 2021
- Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet–induced hepatic steatosis and insulin resistance by elevating IL-18 levels., 刘雯, 尹烨, 王美静, 范婷, 朱玉玉, 沈丽红, 彭爽, 高健, 邓国良, 孟祥宝, 孔令东, 冯根生, 郭文杰, 徐强, 孙阳, 2020
- Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis., 郭文杰, 刘雯, 陈Z, 顾Y, 彭S, 沈L, 沈Y, 王X, 冯GS, 孙Y, 徐Q, 2017