Areas of Focus
- Macrophage immune regulation and related immunotherapy technologies
- Reprogramming of macrophage functions
Work Experience
- Current - Nanjing University Model Animal Research Center - Principal Investigator
Academic Background & Achievements
- Selected for the Ministry of Education's New Century Excellent Talents Program in 2006
- Received over 30 grants including National Key R&D Program, NSFC Major Research Plan
Publications
- Intervening pyruvate carboxylase stunts tumor growth by strengthening anti-tumor actions of tumor-associated macrophages., Y.X. Shu, N.F. Yang, N. Cheng, Z.Y. Zou, W.L. Zhang, Y.C. Bei, Q. Shi, M.H. Qin, W.G. Zhu, P.P. Shen, 2022
- Blockage of PPARγ T166 phosphorylation enhances the inducibility of beige adipocytes and improves metabolic dysfunctions., N.F. Yang, Y.X. Wang, Q. Tian, Q.P. Wang, Y. Lu, L.C. Sun, S.J. Wang, Y.C. Bei, J.G. Ji, H. Zhou, W. Yang, P.J. Yao, W.Y. Zhu, L.Y. Sun, Z.F. Huang, X.K. Li, P.P. Shen, 2023
- Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs., Z.Y. Niu, Q. Shi, W.L. Zhang, B. Chen, Q.S. Wang, X.Y. Zhao, J.J. Chen, Y.X. Shu, N. Cheng, X.J. Feng, J.G. Ji, P.P. Shen, 2017
- CDK5 Inhibition Abrogates TNBC Stem-cell Property and Enhances Anti-PD-1 Therapy., Y.C. Bei, N. Cheng, T. Chen, Y.X. Shu, Y. Yang, N.F. Yang, X.Y. Zhou, B.R. Liu, J. Wei, Q. Liu, W. Zheng, W.L. Zhang, H.F. Su, W.G. Zhu, J.G. Ji, P.P. Shen, 2020
- Crosstalk between IL-15Rα+ tumor-associated macrophages and breast cancer cells reduces CD8+ T cell recruitment., W.L. Zhang, Q. Zhang, N.F. Yang, Q. Shi, H.F. Su, T.S. Lin, Z.L. He, W.X. Wang, H.Q. Guo, P.P. Shen, 2022
- Treatment of obesity-related inflammation with a novel synthetic pentacyclic oleanane triterpenoids via modulation of macrophage polarization., N.F. Yang, Q. Tang, W.T. Qin, Z.Y. Li, D.D. Wang, W.J. Zhang, X. Cao, Y. Lu, X.Y. Ge, H.B. Sun, P.P. Shen, 2019
- An ultrasensitive electrochemical immunosensor for procalcitonin detection based on the gold nanoparticles-enhanced tyramide signal amplification strategy., P. Liu, C. Li, R.X. Zhang, Q. Tang, J. Wei, Y. Lu, P.P. Shen, 2019
- Porous Silicon Nanocarriers Boost the Immunomodulation of Mitochondria Targeted Bovine Serum Albumins on Macrophage Polarization., J.L. Li, J.Q. Fan, Y. Gao, S.D. Huang, D. Huang, J.C. Li, X.Y. Wang, Hélder A. Santos, P.P. Shen, B. Xia, 2023
- Establishment of a novel mesenchymal stem cell-based regimen for chronic myeloid leukemia differentiation therapy., S.M. Zuo, L.C. Sun, Y.X. Wang, B. Chen, J.Y. Wang, X.Y. Ge, Y. Lu, N.F. Yang, P.P. Shen, 2021
- Chimeric antigen receptor macrophage therapy for breast tumours mediated by targeting the tumour extracellular matrix., W.L. Zhang, L. Liu, H.F. Su, Q. Liu, J. Shen, H.R. Dai, W. Zheng, Y. Lu, W.J. Zhang, Y.C. Bei, P.P. Shen, 2019
Awards
- 2014: Jiangsu Province Science and Technology First Prize
- 12th World Congress on Advances in Oncology: Outstanding Achievement Award