2017: Jiangsu Province Science and Technology First Prize
2020: China Invention Association Invention and Entrepreneurship Award (Achievement Award) First Prize
2017: Jiangsu Medical Science and Technology Progress Award Second Prize
Research
Non-apoptotic functions of classical apoptotic protein FADD Lipid metabolism, energy metabolism, and obesity intervention Tumor gene therapy
Combined Cellular Thermometry Reveals That Salmonella typhimurium Warms Macrophages by Inducing a Pyroptosis-like Phenotype, Wu L, Chen F, Chang X, Li L, Yin X, Li C, Wang F, Li C, Xu Q, Zhuang H, Gu N, Hua ZC, 2022
Herbal compound triptolide synergistically enhanced antitumor activity of amino-terminal fragment of urokinase, Lin Y, Peng N, Li J, Zhuang H, Hua ZC, 2013
FADD is a key regulator of lipid metabolism, Zhuang H, Wang X, Zha D, Gan Z, Cai F, Du P, Yang Y, Yang B, Zhang X, Yao C, Zhou Y, Jiang C, Guan S, Zhang X, Zhang J, Jiang W, Hu Q, Hua ZC, 2016
Extracellular signal regulated kinase 5 promotes cell migration, invasion and lung metastasis in a FAK-dependent manner, Jiang W, Cai F, Xu H, Lu Y, Chen J, Liu J, Cao N, Zhang X, Chen X, Huang Qilai, Zhuang H, Hua ZC, 2020
Extracellular signal-regulated kinase 5 increases radioresistance of lung cancer cells by enhancing the DNA damage response, Jiang W, Jin G, Cai F, Chen X, Cao N, Zhang X, Liu J, Chen F, Wang F, Dong W, Zhuang H, Hua ZC, 2019
Sulfide:quinone oxidoreductase alleviates ferroptosis in acute kidney injury via ameliorating mitochondrial dysfunction of renal tubular epithelial cells, Cai F, Li D, Xie Y, Wang X, Ma H, Xu H, Cheng J, Zhuang H, Hua ZC, 2023
Tannic acid assisted anti-TNF-α nanobody assembly modulating the epithelial barrier dysregulation of allergic rhinitis, Fu S, Cao Z, Huang B, Yin T, Huang C, Bi Z, Yao Y, Chang X, Zhuang H, Hua ZC, 2023
ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis, Bi Z, Chen J, Chang X, Li D, Yao Y, Cai F, Xu H, Cheng J, Hua ZC, Zhuang H, 2023
ADT-OH, a hydrogen sulfide-releasing donor, induces apoptosis and inhibits the development of melanoma in vivo by upregulating FADD, Cai F, Xu H, Cao N, Zhang X, Liu J, Lu Y, Chen J, Yang Y, Cheng J, Hua ZC, Zhuang H, 2020
Hydrogel-metal-organic-framework hybrids mediated efficient oral delivery of siRNA for the treatment of ulcerative colitis, Gao M, Yang C, Wu C, Chen Y, Zhuang H, Wang J, Cao Z, 2022
Characterization and Analysis of the Temporal and Spatial Dynamic of Several Enteritis Modeling Methodologies, Xu H, Cai F, Li P, Wang X, Yao Y, Chang X, Bi Z, Sun H, Zhuang H, Hua ZC, 2021
Emerging roles of hnRNP A2B1 in cancer and inflammation, Xu H, Li P, Wang X, Zhuang H, Hua ZC, 2022
ADT-OH inhibits malignant melanoma metastasis in mice via suppressing CSE/CBS and FAK/Paxillin signaling pathway, Cai FF, Xu HR, Yu SH, Li P, Lu YY, Chen J, Bi ZQ, Sun HS, Cheng J, Zhuang HQ, Hua ZC, 2022
Role of FADD Phosphorylation in Regulating Glucose Homeostasis: from Proteomic Discovery to Physiological Validation, Yao C, Zhuang H, Du P, Cheng W, Yang B, Guan S, Hu Y, Zhu D, Christine M, Shi L, Hua ZC, 2013
Proteomic screening of anaerobically regulated promoters from Salmonella and its antitumor applications, Chen J, Wei D, Zhuang H, Qiao Y, Tang B, Zhang X, Wei J, Fang S, Chen G, Du P, Huang X, Jiang W, Hu Q, Hua ZC, 2011
FADD phosphorylation impaired islet morphology and function, Yao C, Zhuang H, Cheng W, Lin Y, Du P, Yang B, Huang X, Chen S, Hu Q, Hua ZC, 2015
Recombinant Bifidobacterium longum Carrying Endostatin Protein Alleviates Dextran Sodium Sulfate-Induced Colitis and Colon Cancer in Rats, Bi Z, Cui E, Yao Y, Chang X, Wang X, Zhang Y, Xu GX, Zhuang H, Hua ZC, 2022
Down-regulation of HSP27 sensitizes TRAIL-resistant tumor cell to TRAIL-induced apoptosis, Zhuang H, Jiang W, Cheng W, Qian K, Dong W, Cao L, Huang Q, Li S, Dou F, Chiu JF, Fang XX, Lu M, Hua ZC, 2010
Metformin Synergistically Enhanced the Antitumor Activity of Celecoxib in Human Non-Small Cell Lung Cancer Cells, Cao N, Lu Y, Liu J, Cai F, Xu H, Chen J, Zhang X, Hua ZC, Zhuang H, 2020
AK2 Promotes the Migration and Invasion of Lung Adenocarcinoma by Activating TGF-β/Smad Pathway In vitro and In vivo, Cai F, Xu H, Zha D, Wang X, Li P, Yu S, Yao Y, Chang X, Chen J, Lu Y, Hua ZC, Zhuang H, 2021
Suppression of HSP70 expression sensitizes NSCLC cell lines to TRAIL-induced apoptosis by upregulating DR4 and DR5 and downregulating c-FLIP-L expressions, Zhuang H, Jiang W, Zhang X, Qiu F, Gan Z, Cheng W, Zhang J, Guan S, Tang B, Huang Q, Wu X, Huang X, Jiang W, Hu Q, Lu M, Hua ZC, 2013
Aspirin potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer by targeting GRP78 activity, Zhang X, Chen J, Cheng C, Li P, Cai F, Xu H, Lu Y, Cao N, Liu J, Wang J, Hua ZC, Zhuang H, 2020
Comparative proteomics analysis reveals roles for FADD in the regulation of energy metabolism and proteolysis pathway in mouse embryonic fibroblast, Zhuang H, Gan Z, Jiang W, Zhang X, Hua ZC, 2013
FADD phosphorylation contributes to development of renal fibrosis by accelerating epithelial-mesenchymal transition, Lin Y, Cai F, Wang X, Yang Y, Ren Y, Yao C, Yin X, Zhuang H, Hua Z, 2022
Apigenin potentiates TRAIL therapy of non-small cell lung cancer via upregulating DR4/DR5 expression in a p53-dependent manner, Chen M, Wang X, Zha D, Cai F, Zhang W, He Y, Huang Q, Zhuang H, Hua ZC, 2016
Heat shock proteins HSP70 and MRJ cooperatively regulate cell adhesion and migration through urokinase receptor, Lin Y, Peng N, Zhuang H, Zhang D, Wang Y, Hua ZC, 2014
FADD phosphorylation modulates blood glucose levels by decreasing the expression of insulin-degrading enzyme, Lin Y, Liu J, Chen J, Yao C, Yang Y, Wang J, Zhuang H, Hua ZC, 2020
Functional specific roles of FADD: comparative proteomic analyses from knockout cell lines, Zhuang H, Gan Z, Jiang W, Zhang X, Hua ZC, 2013
Expression, Purification and Biological Characterization of The Amino-Terminal Fragment of Urokinase in Pichia pastoris, Li J, Lin Y, Zhuang H, Hua ZC, 2013
Herbal compound triptolide synergistically enhanced antitumor activity of vasostatin120-180, Lin Y, Yang X, Lu M, Zheng W, Zhang J, Zhuang H, Hua ZC, 2013
Expression, purification and biological characterization of human vasostatin120–180 in Pichia pastoris, Lin Y, Yang X, Lu M, Zhuang H, Hua ZC, 2013
Area of Focus
Cancer | Cell Signaling | Tgf-Beta | Epithelial-Mesenchymal Transition | Cell Proliferation | Apoptosis | Breast Cancer | Gene Expression | Protein Degradation | Molecular Pathways
