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Jing He
Life Science
Huazhong Agricultural University
Hubei
Language: English, Chinese, German
Streptomyces
Secondary Metabolism
Synthesis
Regulation
Resistance
Mechanisms
Antibiotics
Biosynthesis
Genetic Manipulation
Microbiology
Areas of Focus
- Streptomyces secondary metabolism synthesis, regulation, and resistance mechanisms
Work Experience
- 2005-2007 - Rheinische Friedrich-Wilhelms-Universität Bonn - Postdoctoral Researcher
- 2007-2008 - University of Chicago - Postdoctoral Researcher
- 2008-present - Huazhong Agricultural University - Professor
Academic Background & Achievements
- 1995-1999 Bachelor of Science in Biotechnology: Huazhong Agricultural University
- 1998-2001 Master of Science in Biochemistry and Molecular Biology: Huazhong Agricultural University
- 2001-2005 Doctor of Science: Friedrich-Schiller-Universität Jena
Publications
- Identification of an unusual type II thioesterase in the dithiolopyrrolone antibiotics biosynthetic pathway., Ying Zhai, Silei Bai, Jingjing Liu, Liyuan Yang, Li Han, Xueshi Huang, Jing He*, 2016
- Characterization of a novel DNA glycosylase from S. sahachiroi involved in the reduction and repair of azinomycin B induced DNA damage., Shan Wang, Kai Liu, Le Xiao, LiYuan Yang, Hong Li, FeiXue Zhang, Lei Lei, ShengQing Li, Xu Feng, AiYing Li, Jing He*, 2016
- Accumulation of a bioactive benzoisochromanequinone compound kalafungin by wild type antitumor-medermycin-producing streptomycete strain., Jin Lu, Qiang He, Luyao Huang, Xiaofeng Cai, Wenwen Guo, Jing He, Lili Zhang, Aiying Li*, 2015
- Multifactorial control of iteration events in a modular polyketide assembly line., Benjamin Busch, Nico Ueberschaar, Swantje Behnken, Yuki Sugimoto, Martina Werneburg, Nelly Traitcheva, Jing He, Christian Hertweck, 2013
- Essential role of an unknown gene aziU3 in the production of antitumor antibiotic azinomycin B verified by utilizing optimized genetic manipulation systems for Streptomyces sahachiroi., Shan Wang, Ruifang Zhao, Kai Liu, Mengyi Zhu, Aiying Li, Jing He*, 2012
- Identification and heterologous expression of the biosynthetic gene cluster for holomycin produced by Streptomyces clavuligerus., Sheng Huang, Yudong Zhao, Zhiwei Qin, Xiaoling Wang, Mayca Onega, Li Chen, Jing He*, Yi Yu*, Hai Deng*, 2011
- Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues., Martina Werneburg, Benjamin Busch, Jing He, Martin E.A. Richter, Longkuan Xiang, Bradley S. Moore, Martin Roth, Hans-Martin Dahse, Christian Hertweck, 2010
- Identifying natural product biosynthetic genes from a soil metagenome by using T7 phage selection., Keya Zhang, Jing He, Min Yang, Jun Yin, 2009
- Non-colinear polyketide biosynthesis in the aureothin and neoaureothin pathways: an evolutionary perspective., Nelly Traitcheva, Holger Jenke-Kodama, Jing He, Elke Dittmann and Christian Hertweck, 2007
- Dissection of the late steps in aureothin biosynthesis., Markus Muller, Jing He, Christian Hertweck, 2006
- Functional Analysis of the Aureothin Iterative Type I Polyketide Synthase., Jing He and Christian Hertweck, 2005
- Mutasynthesis of Aureonitrile, an Aureothin Derivative with Significant Cytostatic Effect., Martina Ziehl, Jing He, H.-M. Dahse and Christian Hertweck, 2005
- Formation of the Aureothin Tetrahydrofuran Ring by a Bifunctional Cytochrome P450 Monooxygenase., Jing He, Markus Müller and Christian Hertweck, 2004
- Biosynthetic Origin of the Rare Nitro Aryl Moiety of the Polyketide Antibiotic Aureothin: Discovery of an Unprecedented N-Oxygenase., Jing He and Christian Hertweck, 2004
- Iteration as Programmed Event during Polyketide Assembly; Molecular Analysis of the Aureothin Biosynthesis Gene Cluster., Jing He and Christian Hertweck, 2003
- Organizational and Mutational Analysis of a Complete FR-008/ Candicidin Gene Cluster Encoding a Structurally Related Polyene Complex., Shi Chen, Xi Huang, Xiufen Zhou, Linquan Bai, Jing He, Ki Jun Jeong, Sang Yup Lee, and Zixin Deng, 2003
Awards
- 2009: Selected for the Ministry of Education's New Century Excellent Talents Support Program
- 2004: National Outstanding Self-Financed Student Scholarship
