Professor | Jing He | Asia Growth Partners

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Name	Jing He
Contact Information	hejingjj@mail.hzau.edu.cn
Language ability	English, Chinese, German
Province	Hubei

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Name

Jing He

Contact Information

hejingjj@mail.hzau.edu.cn

Language ability

English, Chinese, German

Province

Hubei

University/Lab Affiliation and Title	Huazhong Agricultural University
Faculty	Life Sciences
Academic Background & Achievements	1995-1999 Bachelor of Science in Biotechnology: Huazhong Agricultural University 1998-2001 Master of Science in Biochemistry and Molecular Biology: Huazhong Agricultural University 2001-2005 Doctor of Science: Friedrich-Schiller-Universität Jena
Work Experience	2005-2007 - Rheinische Friedrich-Wilhelms-Universität Bonn - Postdoctoral Researcher 2007-2008 - University of Chicago - Postdoctoral Researcher 2008-present - Huazhong Agricultural University - Professor
Awards	2009: Selected for the Ministry of Education's New Century Excellent Talents Support Program 2004: National Outstanding Self-Financed Student Scholarship

University/Lab Affiliation and Title

Huazhong Agricultural University

Faculty

Life Sciences

Academic Background & Achievements

1995-1999 Bachelor of Science in Biotechnology: Huazhong Agricultural University
1998-2001 Master of Science in Biochemistry and Molecular Biology: Huazhong Agricultural University
2001-2005 Doctor of Science: Friedrich-Schiller-Universität Jena

Work Experience

2005-2007 - Rheinische Friedrich-Wilhelms-Universität Bonn - Postdoctoral Researcher
2007-2008 - University of Chicago - Postdoctoral Researcher
2008-present - Huazhong Agricultural University - Professor

Awards

2009: Selected for the Ministry of Education's New Century Excellent Talents Support Program
2004: National Outstanding Self-Financed Student Scholarship

Areas of Focus	Streptomyces secondary metabolism synthesis, regulation, and resistance mechanisms
Publications	Identification of an unusual type II thioesterase in the dithiolopyrrolone antibiotics biosynthetic pathway., Ying Zhai, Silei Bai, Jingjing Liu, Liyuan Yang, Li Han, Xueshi Huang, Jing He, 2016 Characterization of a novel DNA glycosylase from S. sahachiroi involved in the reduction and repair of azinomycin B induced DNA damage., Shan Wang, Kai Liu, Le Xiao, LiYuan Yang, Hong Li, FeiXue Zhang, Lei Lei, ShengQing Li, Xu Feng, AiYing Li, Jing He, 2016 Accumulation of a bioactive benzoisochromanequinone compound kalafungin by wild type antitumor-medermycin-producing streptomycete strain., Jin Lu, Qiang He, Luyao Huang, Xiaofeng Cai, Wenwen Guo, Jing He, Lili Zhang, Aiying Li, 2015 Multifactorial control of iteration events in a modular polyketide assembly line., Benjamin Busch, Nico Ueberschaar, Swantje Behnken, Yuki Sugimoto, Martina Werneburg, Nelly Traitcheva, Jing He, Christian Hertweck, 2013 Essential role of an unknown gene aziU3 in the production of antitumor antibiotic azinomycin B verified by utilizing optimized genetic manipulation systems for Streptomyces sahachiroi., Shan Wang, Ruifang Zhao, Kai Liu, Mengyi Zhu, Aiying Li, Jing He, 2012 Identification and heterologous expression of the biosynthetic gene cluster for holomycin produced by Streptomyces clavuligerus., Sheng Huang, Yudong Zhao, Zhiwei Qin, Xiaoling Wang, Mayca Onega, Li Chen, Jing He, Yi Yu, Hai Deng*, 2011 Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues., Martina Werneburg, Benjamin Busch, Jing He, Martin E.A. Richter, Longkuan Xiang, Bradley S. Moore, Martin Roth, Hans-Martin Dahse, Christian Hertweck, 2010 Identifying natural product biosynthetic genes from a soil metagenome by using T7 phage selection., Keya Zhang, Jing He, Min Yang, Jun Yin, 2009 Non-colinear polyketide biosynthesis in the aureothin and neoaureothin pathways: an evolutionary perspective., Nelly Traitcheva, Holger Jenke-Kodama, Jing He, Elke Dittmann and Christian Hertweck, 2007 Dissection of the late steps in aureothin biosynthesis., Markus Muller, Jing He, Christian Hertweck, 2006 Functional Analysis of the Aureothin Iterative Type I Polyketide Synthase., Jing He and Christian Hertweck, 2005 Mutasynthesis of Aureonitrile, an Aureothin Derivative with Significant Cytostatic Effect., Martina Ziehl, Jing He, H.-M. Dahse and Christian Hertweck, 2005 Formation of the Aureothin Tetrahydrofuran Ring by a Bifunctional Cytochrome P450 Monooxygenase., Jing He, Markus Müller and Christian Hertweck, 2004 Biosynthetic Origin of the Rare Nitro Aryl Moiety of the Polyketide Antibiotic Aureothin: Discovery of an Unprecedented N-Oxygenase., Jing He and Christian Hertweck, 2004 Iteration as Programmed Event during Polyketide Assembly; Molecular Analysis of the Aureothin Biosynthesis Gene Cluster., Jing He and Christian Hertweck, 2003 Organizational and Mutational Analysis of a Complete FR-008/ Candicidin Gene Cluster Encoding a Structurally Related Polyene Complex., Shi Chen, Xi Huang, Xiufen Zhou, Linquan Bai, Jing He, Ki Jun Jeong, Sang Yup Lee, and Zixin Deng, 2003

Areas of Focus

Streptomyces secondary metabolism synthesis, regulation, and resistance mechanisms

Publications

Identification of an unusual type II thioesterase in the dithiolopyrrolone antibiotics biosynthetic pathway., Ying Zhai, Silei Bai, Jingjing Liu, Liyuan Yang, Li Han, Xueshi Huang, Jing He*, 2016
Characterization of a novel DNA glycosylase from S. sahachiroi involved in the reduction and repair of azinomycin B induced DNA damage., Shan Wang, Kai Liu, Le Xiao, LiYuan Yang, Hong Li, FeiXue Zhang, Lei Lei, ShengQing Li, Xu Feng, AiYing Li, Jing He*, 2016
Accumulation of a bioactive benzoisochromanequinone compound kalafungin by wild type antitumor-medermycin-producing streptomycete strain., Jin Lu, Qiang He, Luyao Huang, Xiaofeng Cai, Wenwen Guo, Jing He, Lili Zhang, Aiying Li*, 2015
Multifactorial control of iteration events in a modular polyketide assembly line., Benjamin Busch, Nico Ueberschaar, Swantje Behnken, Yuki Sugimoto, Martina Werneburg, Nelly Traitcheva, Jing He, Christian Hertweck, 2013
Essential role of an unknown gene aziU3 in the production of antitumor antibiotic azinomycin B verified by utilizing optimized genetic manipulation systems for Streptomyces sahachiroi., Shan Wang, Ruifang Zhao, Kai Liu, Mengyi Zhu, Aiying Li, Jing He*, 2012
Identification and heterologous expression of the biosynthetic gene cluster for holomycin produced by Streptomyces clavuligerus., Sheng Huang, Yudong Zhao, Zhiwei Qin, Xiaoling Wang, Mayca Onega, Li Chen, Jing He*, Yi Yu*, Hai Deng*, 2011
Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues., Martina Werneburg, Benjamin Busch, Jing He, Martin E.A. Richter, Longkuan Xiang, Bradley S. Moore, Martin Roth, Hans-Martin Dahse, Christian Hertweck, 2010
Identifying natural product biosynthetic genes from a soil metagenome by using T7 phage selection., Keya Zhang, Jing He, Min Yang, Jun Yin, 2009
Non-colinear polyketide biosynthesis in the aureothin and neoaureothin pathways: an evolutionary perspective., Nelly Traitcheva, Holger Jenke-Kodama, Jing He, Elke Dittmann and Christian Hertweck, 2007
Dissection of the late steps in aureothin biosynthesis., Markus Muller, Jing He, Christian Hertweck, 2006
Functional Analysis of the Aureothin Iterative Type I Polyketide Synthase., Jing He and Christian Hertweck, 2005
Mutasynthesis of Aureonitrile, an Aureothin Derivative with Significant Cytostatic Effect., Martina Ziehl, Jing He, H.-M. Dahse and Christian Hertweck, 2005
Formation of the Aureothin Tetrahydrofuran Ring by a Bifunctional Cytochrome P450 Monooxygenase., Jing He, Markus Müller and Christian Hertweck, 2004
Biosynthetic Origin of the Rare Nitro Aryl Moiety of the Polyketide Antibiotic Aureothin: Discovery of an Unprecedented N-Oxygenase., Jing He and Christian Hertweck, 2004
Iteration as Programmed Event during Polyketide Assembly; Molecular Analysis of the Aureothin Biosynthesis Gene Cluster., Jing He and Christian Hertweck, 2003
Organizational and Mutational Analysis of a Complete FR-008/ Candicidin Gene Cluster Encoding a Structurally Related Polyene Complex., Shi Chen, Xi Huang, Xiufen Zhou, Linquan Bai, Jing He, Ki Jun Jeong, Sang Yup Lee, and Zixin Deng, 2003

Streptomyces Secondary Metabolism Synthesis Regulation Resistance Mechanisms Antibiotics Biosynthesis Genetic Manipulation Microbiology

Yinhua Lu - Shanghai Normal University

Hua Yuan - Shanghai Normal University

Xiaobin Wu - Shanghai Normal University

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