Professor | Yan Yan | Asia Growth Partners

Name	Yan Yan
Contact Information	yanyan@mail.hzau.edu.cn
Language ability	English, Chinese
Province	Hubei

Name

Yan Yan

Contact Information

yanyan@mail.hzau.edu.cn

Language ability

English, Chinese

Province

Hubei

University/Lab Affiliation and Title	Huazhong Agricultural University
Faculty	Life Sciences
Academic Background & Achievements	2011/01-2018/08 PhD in Genetics: University of Helsinki 2006/09-2008/06 Master's in Microbiology: Wuhan University 2002/09-2006/06 Bachelor's in Biotechnology: Hunan Agricultural University
Work Experience	2022/04-present - Huazhong Agricultural University - Researcher, Doctoral Supervisor 2023/07-present - Hubei Hongshan Laboratory - Fixed Researcher 2021/07-2022/03 - Memorial Sloan Kettering Cancer Center, USA - Associate Researcher 2018/08-2021/06 - Memorial Sloan Kettering Cancer Center, USA - Postdoctoral Researcher 2008/08-2010/12 - University of Helsinki - Research Assistant
Awards	2024: National Overseas High-Level Young Talent 2022: Hubei Province Overseas High-Level Talent 2023: Huazhong Agricultural University Teaching Excellence Award 2017: University of Helsinki President's Scholarship 2016: Outstanding Young Scientist at Helsinki Biomedical Center 2016: National Outstanding Self-Funded Student Scholarship 2005: Second Prize in National College English Competition

University/Lab Affiliation and Title

Huazhong Agricultural University

Faculty

Life Sciences

Academic Background & Achievements

2011/01-2018/08 PhD in Genetics: University of Helsinki
2006/09-2008/06 Master's in Microbiology: Wuhan University
2002/09-2006/06 Bachelor's in Biotechnology: Hunan Agricultural University

Work Experience

2022/04-present - Huazhong Agricultural University - Researcher, Doctoral Supervisor
2023/07-present - Hubei Hongshan Laboratory - Fixed Researcher
2021/07-2022/03 - Memorial Sloan Kettering Cancer Center, USA - Associate Researcher
2018/08-2021/06 - Memorial Sloan Kettering Cancer Center, USA - Postdoctoral Researcher
2008/08-2010/12 - University of Helsinki - Research Assistant

Awards

2024: National Overseas High-Level Young Talent
2022: Hubei Province Overseas High-Level Talent
2023: Huazhong Agricultural University Teaching Excellence Award
2017: University of Helsinki President's Scholarship
2016: Outstanding Young Scientist at Helsinki Biomedical Center
2016: National Outstanding Self-Funded Student Scholarship
2005: Second Prize in National College English Competition

Areas of Focus	Systematic identification of tumor stem cell-like populations Identification of key genes and signaling pathways maintaining tumor stem cell characteristics, heterogeneity, and drug resistance Analysis of cellular characteristics in tumor stem cell niches and metastatic sites
Publications	A classical epithelial state drives acute resistance to KRAS inhibition in pancreas cancer., Singhal A, Styers HC, Rub J, Li Z, Torborg SR, Kim JY, Grbovic-Huezo O, Feng H, Tarcan ZC, Sahin Ozkan H, Hallin J, Basturk O, Yaeger R, Christensen JG, Betel D, Yan Y, Chio IIC, de Stanchina E, Tammela T., 2024 Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma., Li Z, Zhuang X, Pan CH, Yan Y, Thummalapalli R, Hallin J, Torborg S, Singhal A, Chang JC, Manchado E, Dow LE, Yaeger R, Christensen JG, Lowe SW, Rudin CM, Joost S, Tammela T., 2024 Inactivation of AMPK leads to attenuation of antigen presentation and immune evasion in lung adenocarcinoma., Gao Y, Päivinen P, Tripathi S, Domènech-Moreno E, Wong IP, Vaahtomeri K, Nagaraj AS, Talwelkar SS, Foretz M, Verschuren EW, Viollet B, Yan Y, Mäkelä TP., 2022 A MASCOT for mosaic analysis., Yan Y and Tammela T., 2020 LKB1 represses ATOH1 via PDK4 and energy metabolism and regulates intestinal stem cell fate., Gao Y, Yan Y, Tripathi S, Pentinmikko N, Amaral A, Pävinen P, Domènech-Moreno E, Andersson S, Wong IP, Clevers H, Katajisto P, Mäkelä TP., 2020 SUMOylation of AMPKα1 by PIAS4 specifically regulates mTORC1 signaling., Yan Y, Ollila S, Wong IP, Vallenius T, Palvimo JJ, Vaahtomeri K, Mäkelä TP., 2015 Emergence of a high-plasticity cell state during lung cancer evolution., Marjanovic ND, Hofree M, Chan JE, Canner D, Wu K, Trakala M, Hartmann G, Smith O, Kim J, Evans KV, Hudson A, Ashenberg O, Porter C, Subramanian A, Pitter K, Yan Y, Delroy T, Philips DR, Tsankov A, Shah N, Chaudhary O, Hollmann T, Rekhtman N, Massion PP, Poirier JT, Mazutis L, Lee JH, Amon A, Rudin CM, Jacks T, Regev A, Tammela T., 2020 Stromal loss of Lkb1 drives gastrointestinal tumorigenesis involving the IL-11-Jak/Stat3 pathway., Ollila S, Domènech-Moreno E, Laajanen K, Wong IP, Tripathi S, Pentinmikko N, Gao Y, Yan Y, Niemelä EH, Wang TC, Viollet B, Leone G, Katajisto P, Vaahtomeri K, Mäkelä TP., 2018 AMPK negatively regulates tensin-dependent integrin activity., Georgiadou M, Lilja J, Jacquemet G, Guzman C, Rafaeva M, Alibert C, Yan Y, Sahgal P, Lerche M, Manneville JB, Mäkelä TP, Ivaska J., 2017 Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis., Nieminen AI, Eskelinen VM, Haikala HM, Tervonen TA, Yan Y, Partanen JI, Klefström J., 2013 Borna disease virus P protein affects neural transmission through interactions with gamma-aminobutyric acid receptor-associated protein., Peng G, Yan Y, Zhu C, Wang S, Yan X, Lu L, Li W, Hu J, Wei W, Mu Y, Chen Y, Feng Y, Gong R, Wu K, Zhang F, Zhang X, Zhu Y, Wu J., 2008

Areas of Focus

Systematic identification of tumor stem cell-like populations
Identification of key genes and signaling pathways maintaining tumor stem cell characteristics, heterogeneity, and drug resistance
Analysis of cellular characteristics in tumor stem cell niches and metastatic sites

Publications

A classical epithelial state drives acute resistance to KRAS inhibition in pancreas cancer., Singhal A, Styers HC, Rub J, Li Z, Torborg SR, Kim JY, Grbovic-Huezo O, Feng H, Tarcan ZC, Sahin Ozkan H, Hallin J, Basturk O, Yaeger R, Christensen JG, Betel D, Yan Y, Chio IIC, de Stanchina E, Tammela T., 2024
Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma., Li Z, Zhuang X, Pan CH, Yan Y, Thummalapalli R, Hallin J, Torborg S, Singhal A, Chang JC, Manchado E, Dow LE, Yaeger R, Christensen JG, Lowe SW, Rudin CM, Joost S, Tammela T., 2024
Inactivation of AMPK leads to attenuation of antigen presentation and immune evasion in lung adenocarcinoma., Gao Y, Päivinen P, Tripathi S, Domènech-Moreno E, Wong IP, Vaahtomeri K, Nagaraj AS, Talwelkar SS, Foretz M, Verschuren EW, Viollet B, Yan Y, Mäkelä TP., 2022
A MASCOT for mosaic analysis., Yan Y and Tammela T., 2020
LKB1 represses ATOH1 via PDK4 and energy metabolism and regulates intestinal stem cell fate., Gao Y, Yan Y, Tripathi S, Pentinmikko N, Amaral A, Pävinen P, Domènech-Moreno E, Andersson S, Wong IP, Clevers H, Katajisto P, Mäkelä TP., 2020
SUMOylation of AMPKα1 by PIAS4 specifically regulates mTORC1 signaling., Yan Y, Ollila S, Wong IP, Vallenius T, Palvimo JJ, Vaahtomeri K, Mäkelä TP., 2015
Emergence of a high-plasticity cell state during lung cancer evolution., Marjanovic ND, Hofree M, Chan JE, Canner D, Wu K, Trakala M, Hartmann G, Smith O, Kim J, Evans KV, Hudson A, Ashenberg O, Porter C, Subramanian A, Pitter K, Yan Y, Delroy T, Philips DR, Tsankov A, Shah N, Chaudhary O, Hollmann T, Rekhtman N, Massion PP, Poirier JT, Mazutis L, Lee JH, Amon A, Rudin CM, Jacks T, Regev A, Tammela T., 2020
Stromal loss of Lkb1 drives gastrointestinal tumorigenesis involving the IL-11-Jak/Stat3 pathway., Ollila S, Domènech-Moreno E, Laajanen K, Wong IP, Tripathi S, Pentinmikko N, Gao Y, Yan Y, Niemelä EH, Wang TC, Viollet B, Leone G, Katajisto P, Vaahtomeri K, Mäkelä TP., 2018
AMPK negatively regulates tensin-dependent integrin activity., Georgiadou M, Lilja J, Jacquemet G, Guzman C, Rafaeva M, Alibert C, Yan Y, Sahgal P, Lerche M, Manneville JB, Mäkelä TP, Ivaska J., 2017
Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis., Nieminen AI, Eskelinen VM, Haikala HM, Tervonen TA, Yan Y, Partanen JI, Klefström J., 2013
Borna disease virus P protein affects neural transmission through interactions with gamma-aminobutyric acid receptor-associated protein., Peng G, Yan Y, Zhu C, Wang S, Yan X, Lu L, Li W, Hu J, Wei W, Mu Y, Chen Y, Feng Y, Gong R, Wu K, Zhang F, Zhang X, Zhu Y, Wu J., 2008

Tumor Stem Cells Heterogeneity Drug Resistance Genetic Tracing Organoid Culture Gene Editing Single-Cell Sequencing Lung Adenocarcinoma Pancreatic Cancer Liver Cancer

Shubing Zhang - Central South University

Shubing Zhang - Central South University

University of Chinese Academy of Sciences

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