Professor | 颜彦 | 数字化转型顾问

Name	颜彦
Contact Information	yanyan@mail.hzau.edu.cn
Language ability	英语, 中文
Province	湖北

Name

颜彦

Contact Information

yanyan@mail.hzau.edu.cn

Language ability

英语, 中文

Province

湖北

University/Lab Affiliation and Title	华中农业大学
Faculty	Life Sciences
Academic Background & Achievements	2011/01-2018/08 遗传学博士: 赫尔辛基大学 2006/09-2008/06 微生物学硕士: 武汉大学 2002/09-2006/06 生物技术学士: 湖南农业大学
Work Experience	2022/04-至今 - 华中农业大学 - 研究员, 博士生导师 2023/07-至今 - 湖北洪山实验室 - 固定研究人员 2021/07-2022/03 - 美国纪念斯隆-凯特琳癌症中心 - 副研究员 2018/08-2021/06 - 美国纪念斯隆-凯特琳癌症中心 - 博士后 2008/08-2010/12 - 赫尔辛基大学 - 研究助理
Awards	2024: 国家级引进海外高层次青年人才 2022: 湖北省引进海外高层次人才 2023: 华中农业大学教学质量优秀奖 2017: 赫尔辛基大学校长奖学金 2016: 赫尔辛基生物医学中心优秀青年科学家 2016: 国家优秀自费留学生奖学金 2005: 全国大学生英语竞赛二等奖

University/Lab Affiliation and Title

华中农业大学

Faculty

Life Sciences

Academic Background & Achievements

2011/01-2018/08 遗传学博士: 赫尔辛基大学
2006/09-2008/06 微生物学硕士: 武汉大学
2002/09-2006/06 生物技术学士: 湖南农业大学

Work Experience

2022/04-至今 - 华中农业大学 - 研究员, 博士生导师
2023/07-至今 - 湖北洪山实验室 - 固定研究人员
2021/07-2022/03 - 美国纪念斯隆-凯特琳癌症中心 - 副研究员
2018/08-2021/06 - 美国纪念斯隆-凯特琳癌症中心 - 博士后
2008/08-2010/12 - 赫尔辛基大学 - 研究助理

Awards

2024: 国家级引进海外高层次青年人才
2022: 湖北省引进海外高层次人才
2023: 华中农业大学教学质量优秀奖
2017: 赫尔辛基大学校长奖学金
2016: 赫尔辛基生物医学中心优秀青年科学家
2016: 国家优秀自费留学生奖学金
2005: 全国大学生英语竞赛二等奖

Areas of Focus	系统性鉴定具有肿瘤干细胞特性的细胞群体鉴定维持肿瘤干细胞特性、异质性以及耐药的关键基因和信号通路解析肿瘤干细胞巢、肿瘤转移灶中微环境的细胞特征
Publications	A classical epithelial state drives acute resistance to KRAS inhibition in pancreas cancer., Singhal A, Styers HC, Rub J, Li Z, Torborg SR, Kim JY, Grbovic-Huezo O, Feng H, Tarcan ZC, Sahin Ozkan H, Hallin J, Basturk O, Yaeger R, Christensen JG, Betel D, Yan Y, Chio IIC, de Stanchina E, Tammela T., 2024 Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma., Li Z, Zhuang X, Pan CH, Yan Y, Thummalapalli R, Hallin J, Torborg S, Singhal A, Chang JC, Manchado E, Dow LE, Yaeger R, Christensen JG, Lowe SW, Rudin CM, Joost S, Tammela T., 2024 Inactivation of AMPK leads to attenuation of antigen presentation and immune evasion in lung adenocarcinoma., Gao Y, Päivinen P, Tripathi S, Domènech-Moreno E, Wong IP, Vaahtomeri K, Nagaraj AS, Talwelkar SS, Foretz M, Verschuren EW, Viollet B, Yan Y, Mäkelä TP., 2022 A MASCOT for mosaic analysis., Yan Y and Tammela T., 2020 LKB1 represses ATOH1 via PDK4 and energy metabolism and regulates intestinal stem cell fate., Gao Y, Yan Y, Tripathi S, Pentinmikko N, Amaral A, Pävinen P, Domènech-Moreno E, Andersson S, Wong IP, Clevers H, Katajisto P, Mäkelä TP., 2020 SUMOylation of AMPKα1 by PIAS4 specifically regulates mTORC1 signaling., Yan Y, Ollila S, Wong IP, Vallenius T, Palvimo JJ, Vaahtomeri K, Mäkelä TP., 2015 Emergence of a high-plasticity cell state during lung cancer evolution., Marjanovic ND, Hofree M, Chan JE, Canner D, Wu K, Trakala M, Hartmann G, Smith O, Kim J, Evans KV, Hudson A, Ashenberg O, Porter C, Subramanian A, Pitter K, Yan Y, Delroy T, Philips DR, Tsankov A, Shah N, Chaudhary O, Hollmann T, Rekhtman N, Massion PP, Poirier JT, Mazutis L, Lee JH, Amon A, Rudin CM, Jacks T, Regev A, Tammela T., 2020 Stromal loss of Lkb1 drives gastrointestinal tumorigenesis involving the IL-11-Jak/Stat3 pathway., Ollila S, Domènech-Moreno E, Laajanen K, Wong IP, Tripathi S, Pentinmikko N, Gao Y, Yan Y, Niemelä EH, Wang TC, Viollet B, Leone G, Katajisto P, Vaahtomeri K, Mäkelä TP., 2018 AMPK negatively regulates tensin-dependent integrin activity., Georgiadou M, Lilja J, Jacquemet G, Guzman C, Rafaeva M, Alibert C, Yan Y, Sahgal P, Lerche M, Manneville JB, Mäkelä TP, Ivaska J., 2017 Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis., Nieminen AI, Eskelinen VM, Haikala HM, Tervonen TA, Yan Y, Partanen JI, Klefström J., 2013 Borna disease virus P protein affects neural transmission through interactions with gamma-aminobutyric acid receptor-associated protein., Peng G, Yan Y, Zhu C, Wang S, Yan X, Lu L, Li W, Hu J, Wei W, Mu Y, Chen Y, Feng Y, Gong R, Wu K, Zhang F, Zhang X, Zhu Y, Wu J., 2008

Areas of Focus

系统性鉴定具有肿瘤干细胞特性的细胞群体
鉴定维持肿瘤干细胞特性、异质性以及耐药的关键基因和信号通路
解析肿瘤干细胞巢、肿瘤转移灶中微环境的细胞特征

Publications

A classical epithelial state drives acute resistance to KRAS inhibition in pancreas cancer., Singhal A, Styers HC, Rub J, Li Z, Torborg SR, Kim JY, Grbovic-Huezo O, Feng H, Tarcan ZC, Sahin Ozkan H, Hallin J, Basturk O, Yaeger R, Christensen JG, Betel D, Yan Y, Chio IIC, de Stanchina E, Tammela T., 2024
Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma., Li Z, Zhuang X, Pan CH, Yan Y, Thummalapalli R, Hallin J, Torborg S, Singhal A, Chang JC, Manchado E, Dow LE, Yaeger R, Christensen JG, Lowe SW, Rudin CM, Joost S, Tammela T., 2024
Inactivation of AMPK leads to attenuation of antigen presentation and immune evasion in lung adenocarcinoma., Gao Y, Päivinen P, Tripathi S, Domènech-Moreno E, Wong IP, Vaahtomeri K, Nagaraj AS, Talwelkar SS, Foretz M, Verschuren EW, Viollet B, Yan Y, Mäkelä TP., 2022
A MASCOT for mosaic analysis., Yan Y and Tammela T., 2020
LKB1 represses ATOH1 via PDK4 and energy metabolism and regulates intestinal stem cell fate., Gao Y, Yan Y, Tripathi S, Pentinmikko N, Amaral A, Pävinen P, Domènech-Moreno E, Andersson S, Wong IP, Clevers H, Katajisto P, Mäkelä TP., 2020
SUMOylation of AMPKα1 by PIAS4 specifically regulates mTORC1 signaling., Yan Y, Ollila S, Wong IP, Vallenius T, Palvimo JJ, Vaahtomeri K, Mäkelä TP., 2015
Emergence of a high-plasticity cell state during lung cancer evolution., Marjanovic ND, Hofree M, Chan JE, Canner D, Wu K, Trakala M, Hartmann G, Smith O, Kim J, Evans KV, Hudson A, Ashenberg O, Porter C, Subramanian A, Pitter K, Yan Y, Delroy T, Philips DR, Tsankov A, Shah N, Chaudhary O, Hollmann T, Rekhtman N, Massion PP, Poirier JT, Mazutis L, Lee JH, Amon A, Rudin CM, Jacks T, Regev A, Tammela T., 2020
Stromal loss of Lkb1 drives gastrointestinal tumorigenesis involving the IL-11-Jak/Stat3 pathway., Ollila S, Domènech-Moreno E, Laajanen K, Wong IP, Tripathi S, Pentinmikko N, Gao Y, Yan Y, Niemelä EH, Wang TC, Viollet B, Leone G, Katajisto P, Vaahtomeri K, Mäkelä TP., 2018
AMPK negatively regulates tensin-dependent integrin activity., Georgiadou M, Lilja J, Jacquemet G, Guzman C, Rafaeva M, Alibert C, Yan Y, Sahgal P, Lerche M, Manneville JB, Mäkelä TP, Ivaska J., 2017
Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis., Nieminen AI, Eskelinen VM, Haikala HM, Tervonen TA, Yan Y, Partanen JI, Klefström J., 2013
Borna disease virus P protein affects neural transmission through interactions with gamma-aminobutyric acid receptor-associated protein., Peng G, Yan Y, Zhu C, Wang S, Yan X, Lu L, Li W, Hu J, Wei W, Mu Y, Chen Y, Feng Y, Gong R, Wu K, Zhang F, Zhang X, Zhu Y, Wu J., 2008

肿瘤干细胞异质性耐药性遗传谱系示踪类器官培养基因编辑单细胞测序肺腺癌胰腺癌肝癌

高睿 - 同济大学

苏海峰 - 上海大学

余勇 - 同济大学

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