2006-2012: Ph.D. in Biochemistry and Molecular Biology, Shanghai Institute of Life Sciences, Chinese Academy of Sciences
2002-2006: Bachelor's in Life Sciences and Technology, Wuhan University
2020-present: Professor, College of Biomedical and Health Sciences, Huazhong Agricultural University
2019-2020: Lecturer, MD Anderson Cancer Center, University of Texas
2014-2019: Postdoctoral Fellow, MD Anderson Cancer Center, University of Texas
2012-2013: Assistant Researcher, Institute of Nutritional Sciences, Shanghai Institute of Life Sciences, Chinese Academy of Sciences
Research
Molecular mechanisms of tumorigenesis and tumor treatment resistance
A targetable LIFR- NF-κB -LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis., Yao F*#, Deng Y*, Zhao Y, Mei Y, Zhang Y, Liu X, Martinez C, Su X, Rosato R, Teng H, Hang Q, Yap S, Chen D, Wang Y, Chen M, Zhang M, Liang H, Xie D, Chen X, Zhu H, Chang J, You J, Sun Y, Gan B, Ma L#., 2021
Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance., Deng Y, Xia X, Zhao Y, Zhao Z, Martinez C, Yin W, Yao J, Hang Q, Wu W, Zhang J, Yu Y, Xia W, Yao F, Zhao D, Sun Y, Ying H, Hung M, Ma L., 2021
Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance., Hang Q, Zeng L, Wang L, Nie L, Yao F, Teng H, Deng Y, Yap S, Sun Y, Frank SJ, Chen J, Ma L., 2021
Proteome-wide Analysis Reveals Substrates of E3 Ligase RNF146 Targeted for Degradation., Nie L, Wang C, Li N, Feng X, Lee N, Su D, Tang M, Yao F, Chen J., 2020
Challenges and Strategies in Ascribing Functions to Long Noncoding RNAs., Zhao Y, Teng H, Yao F, Yap S, Sun Y, Ma L., 2020
piRNA-unbound PIWIL1 promotes metastasis., Yao F, Ma L., 2020
Long noncoding RNA MALAT1 suppresses breast cancer metastasis., Kim J, Piao HL, Kim BJ, Yao F, Han Z, Wang Y, Xiao Z, Siverly AN, Lawhon SE, Ton BN, Lee H, Zhou Z, Gan B, Nakagawa S, Ellis MJ, Liang H, Hung MC, You MJ, Sun Y, Ma L., 2018
SKP2 and OTUD1 govern non-proteolytic ubiquitination of YAP that promotes YAP nuclear localization and activity., Yao F, Xiao Z, Sun Y, Ma L., 2018
SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity., Yao F, Zhou Z, Kim J, Hang Q, Xiao Z, Ton BN, Chang L, Liu N, Zeng L, Wang W, Wang Y, Zhang P, Hu X, Su X, Liang H, Sun Y, Ma L., 2018
ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer., Zhang P, Xiao Z, Wang S, Zhang M, Wei Y, Hang Q, Kim J, Yao F, Rodriguez-Aguayo C, Ton BN, Lee M, Wang Y, Zhou Z, Zeng L, Hu X, Lawhon SE, Siverly AN, Su X, Li J, Xie X, Cheng X, Liu LC, Chang HW, Chiang SF, Lopez-Berestein G, Sood AK, Chen J, You MJ, Sun SC, Liang H, Huang Y, Yang X, Sun D, Sun Y, Hung MC, Ma L., 2018
Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types., Ge Z, Leighton JS, Wang Y, Peng X, Chen Z, Chen H, Sun Y, Yao F, Li J, Zhang H, Liu J, Shriver CD, Hu H; Cancer Genome Atlas Research Network, Piwnica-Worms H, Ma L, Liang H., 2018
MicroRNAs and metastasis: small RNAs play big roles., Kim J, Yao F, Xiao Z, Sun Y, Ma L., 2018
USP51 promotes deubiquitination and stabilization of ZEB1., Zhou Z, Zhang P, Hu X, Kim J, Yao F, Xiao Z, Zeng L, Chang L, Sun Y, Ma L., 2017
Iron overload in hereditary tyrosinemia type 1 induces liver injury through the Sp1/Tfr2/hepcidin axis., Bao WD, Yao F, Deng YZ, Long LY, Wang JJ, Guan DX, Qian ZY, An P, Feng YY, He ZY, Wang XF, Phillip Koeffler H, Hu R, Wang J, Wang X, Wang F, Li JJ, Xie D., 2016
Recruitment of the phosphatase PP2A by RACK1 adaptor protein deactivates the transcription factor IRF3 and limits type I interferon signaling., Long L, Deng Y, Yao F, Guan D, Feng Y, Jiang H, Li X, Hu P, Lu X, Wang H, Li J, Gao X, Xie D., 2014
RACK1 modulates NF-kappaB activation by interfering with the interaction between TRAF2 and the IKK complex., Yao F, Long LY, Deng YZ, Feng YY, Ying GY, Bao WD, Li G, Guan DX, Zhu YQ, Li JJ and Xie D., 2014
RACK1 suppresses gastric tumorigenesis by stabilizing the beta-catenin destruction complex., Deng YZ, Yao F, Li JJ, Mao ZF, Hu PT, Long LY, Li G, Ji XD, Shi S, Guan DX, et al., 2012
Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model., Feng YX, Wang T, Deng YZ, Yang P, Li JJ, Guan DX, Yao F, Zhu YQ, Qin Y, Wang H, et al., 2011
Area of Focus
Molecular Genetics | Biochemistry | Molecular Biology | Enzymology | Glycobiology | Liver Cancer | Cancer Development | Cancer Treatment | Cancer Diagnosis | Molecular Mechanisms
Area of Focus
Liver Cancer | Molecular Mechanisms | Precision Diagnosis | Biomarkers | Cancer Development | Non-Coding Rna | Protein Interaction | Tumor Growth | Metastasis | Therapeutic Strategies
Area of Focus
Cell Adhesion | Kidney Development | Disease Mechanisms | Lung Cancer | Breast Cancer | Cancer Metastasis | Adenosine | Inflammatory Responses | Molecular Mechanisms | Protein Roles
