Professor | Hongxia Zhang | Asia Growth Partners

Name	Hongxia Zhang
Contact Information	hongxiazhang@mail.hzau.edu.cn
Language ability	Chinese, English
Province	Hubei

Name

Hongxia Zhang

Contact Information

hongxiazhang@mail.hzau.edu.cn

Language ability

Chinese, English

Province

Hubei

University/Lab Affiliation and Title	Huazhong Agricultural University
Faculty	Life Sciences
Academic Background & Achievements	2012/09-2018/06 PhD in Cell Biology: Wuhan University 2008/09-2012/06 Bachelor in Life Sciences and Technology: Lanzhou University
Work Experience	2018/10-2023/11 - Wuhan University Medical Research Institute - Postdoctoral Researcher 2023/12-present - Huazhong Agricultural University, College of Biomedical and Health Sciences - Associate Professor, Doctoral Supervisor
Awards	National Natural Science Foundation Youth Fund (2022-2024): Principal Investigator China Postdoctoral Science Foundation General Grant (2019-2021): Principal Investigator Fourth Batch of National Postdoctoral Innovative Talent Support Program (2019-2021): Principal Investigator

University/Lab Affiliation and Title

Huazhong Agricultural University

Faculty

Life Sciences

Academic Background & Achievements

2012/09-2018/06 PhD in Cell Biology: Wuhan University
2008/09-2012/06 Bachelor in Life Sciences and Technology: Lanzhou University

Work Experience

2018/10-2023/11 - Wuhan University Medical Research Institute - Postdoctoral Researcher
2023/12-present - Huazhong Agricultural University, College of Biomedical and Health Sciences - Associate Professor, Doctoral Supervisor

Awards

National Natural Science Foundation Youth Fund (2022-2024): Principal Investigator
China Postdoctoral Science Foundation General Grant (2019-2021): Principal Investigator
Fourth Batch of National Postdoctoral Innovative Talent Support Program (2019-2021): Principal Investigator

Areas of Focus	Mechanisms and regulatory networks of inflammation during aging Development of gene therapy strategies for rare diseases, especially genetic progeria using animal models
Publications	Enhancement of the viability of T cells electroporated with DNA via osmotic dampening of the DNA-sensing cGAS-STING pathway., An, J., Zhang, C.P., Qiu, H.Y., Zhang, H.X., Chen, Q.B., Zhang, C.X., Yin, H., Zhang, Y., 2023 Cas12a-based one-pot SNP detection with high accuracy., Zhang, H.X., Zhang, C.X., Lu, S.H., Tong, X.H., Zhang, K., Yin, H., Zhang, Y., 2023 Eliminating base-editor-induced genome-wide and transcriptome-wide off-target mutations., Wang, L.J., Xue, W., Zhang, H.X., Gao, R.Z., Qiu, H.Y., Wei, J., Zhou, L.N., Lei, Y.N., Wu, X.C., Li, X., Liu, C.F., Wu, J., Chen, Q.B., Ma, H.H., Huang, X.X., Cai, C.G., Zhang, Y., Yang, B., Hao, Y., Yang, L., Chen, J., 2021 FAM64A positively regulates STAT3 activity to promote Th17 differentiation and colitis-associated carcinogenesis., Xu, Z.S., Zhang, H.X., Li, W.W., Ran, Y., Liu, T.T., Xiong, M.G., Li, Q.L., Wang, S.Y., Wu, M., Shu, H.B., Xia, H.M., Wang, Y.Y., 2019 Genome Editing with mRNA Encoding ZFN, TALEN, and Cas9., Zhang, H.X., Zhang, Y., Yin, H., 2019 TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis., Zhang, H.X., Xu, Z.S., Lin, H., Li, M., Xia, T., Cui, K., Wang, S.Y., Li, Y.J., Shu, H.B., Wang, Y.Y., 2018 MARCH3 attenuates IL-1 beta-triggered inflammation by mediating K48-linked polyubiquitination and degradation of IL-1RI., Lin, H., Gao, D., Hu, M.M., Zhang, M., Wu, X.X., Feng, L., Xu, W.H., Yang, Q., Zhong, X., Wei, J., Xu, Z.S., Zhang, H.X., Song, Z.M., Zhou, Q., Ye, W., Liu, Y., Li, S., Shu, H.B., 2018 PASD1 promotes STAT3 activity and tumor growth by inhibiting TC45-mediated dephosphorylation of STAT3 in the nucleus., Xu, Z.S., Zhang, H.X., Zhang, Y.L., Liu, T.T., Ran, Y., Chen, L.T., Wang, Y.Y., Shu, H.B., 2016

Areas of Focus

Mechanisms and regulatory networks of inflammation during aging
Development of gene therapy strategies for rare diseases, especially genetic progeria using animal models

Publications

Enhancement of the viability of T cells electroporated with DNA via osmotic dampening of the DNA-sensing cGAS-STING pathway., An, J., Zhang, C.P., Qiu, H.Y., Zhang, H.X., Chen, Q.B., Zhang, C.X., Yin, H., Zhang, Y., 2023
Cas12a-based one-pot SNP detection with high accuracy., Zhang, H.X., Zhang, C.X., Lu, S.H., Tong, X.H., Zhang, K., Yin, H., Zhang, Y., 2023
Eliminating base-editor-induced genome-wide and transcriptome-wide off-target mutations., Wang, L.J., Xue, W., Zhang, H.X., Gao, R.Z., Qiu, H.Y., Wei, J., Zhou, L.N., Lei, Y.N., Wu, X.C., Li, X., Liu, C.F., Wu, J., Chen, Q.B., Ma, H.H., Huang, X.X., Cai, C.G., Zhang, Y., Yang, B., Hao, Y., Yang, L., Chen, J., 2021
FAM64A positively regulates STAT3 activity to promote Th17 differentiation and colitis-associated carcinogenesis., Xu, Z.S., Zhang, H.X., Li, W.W., Ran, Y., Liu, T.T., Xiong, M.G., Li, Q.L., Wang, S.Y., Wu, M., Shu, H.B., Xia, H.M., Wang, Y.Y., 2019
Genome Editing with mRNA Encoding ZFN, TALEN, and Cas9., Zhang, H.X., Zhang, Y., Yin, H., 2019
TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis., Zhang, H.X., Xu, Z.S., Lin, H., Li, M., Xia, T., Cui, K., Wang, S.Y., Li, Y.J., Shu, H.B., Wang, Y.Y., 2018
MARCH3 attenuates IL-1 beta-triggered inflammation by mediating K48-linked polyubiquitination and degradation of IL-1RI., Lin, H., Gao, D., Hu, M.M., Zhang, M., Wu, X.X., Feng, L., Xu, W.H., Yang, Q., Zhong, X., Wei, J., Xu, Z.S., Zhang, H.X., Song, Z.M., Zhou, Q., Ye, W., Liu, Y., Li, S., Shu, H.B., 2018
PASD1 promotes STAT3 activity and tumor growth by inhibiting TC45-mediated dephosphorylation of STAT3 in the nucleus., Xu, Z.S., Zhang, H.X., Zhang, Y.L., Liu, T.T., Ran, Y., Chen, L.T., Wang, Y.Y., Shu, H.B., 2016

Inflammation Aging Regulatory Networks Gene Therapy Rare Diseases Genetic Progeria Animal Models Cell Biology Biomedical Applications Gene Editing

Jiayu Chen - Tongji University

Anke Geng - Tongji University

Chen Wang - Tongji University

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