Areas of Focus
- Mechanisms and regulatory networks of inflammation during aging
- Development of gene therapy strategies for rare diseases, especially genetic progeria using animal models
Work Experience
- 2018/10-2023/11 - Wuhan University Medical Research Institute - Postdoctoral Researcher
- 2023/12-present - Huazhong Agricultural University, College of Biomedical and Health Sciences - Associate Professor, Doctoral Supervisor
Academic Background & Achievements
- 2012/09-2018/06 PhD in Cell Biology: Wuhan University
- 2008/09-2012/06 Bachelor in Life Sciences and Technology: Lanzhou University
Publications
- Enhancement of the viability of T cells electroporated with DNA via osmotic dampening of the DNA-sensing cGAS-STING pathway., An, J., Zhang, C.P., Qiu, H.Y., Zhang, H.X., Chen, Q.B., Zhang, C.X., Yin, H., Zhang, Y., 2023
- Cas12a-based one-pot SNP detection with high accuracy., Zhang, H.X., Zhang, C.X., Lu, S.H., Tong, X.H., Zhang, K., Yin, H., Zhang, Y., 2023
- Eliminating base-editor-induced genome-wide and transcriptome-wide off-target mutations., Wang, L.J., Xue, W., Zhang, H.X., Gao, R.Z., Qiu, H.Y., Wei, J., Zhou, L.N., Lei, Y.N., Wu, X.C., Li, X., Liu, C.F., Wu, J., Chen, Q.B., Ma, H.H., Huang, X.X., Cai, C.G., Zhang, Y., Yang, B., Hao, Y., Yang, L., Chen, J., 2021
- FAM64A positively regulates STAT3 activity to promote Th17 differentiation and colitis-associated carcinogenesis., Xu, Z.S., Zhang, H.X., Li, W.W., Ran, Y., Liu, T.T., Xiong, M.G., Li, Q.L., Wang, S.Y., Wu, M., Shu, H.B., Xia, H.M., Wang, Y.Y., 2019
- Genome Editing with mRNA Encoding ZFN, TALEN, and Cas9., Zhang, H.X., Zhang, Y., Yin, H., 2019
- TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis., Zhang, H.X., Xu, Z.S., Lin, H., Li, M., Xia, T., Cui, K., Wang, S.Y., Li, Y.J., Shu, H.B., Wang, Y.Y., 2018
- MARCH3 attenuates IL-1 beta-triggered inflammation by mediating K48-linked polyubiquitination and degradation of IL-1RI., Lin, H., Gao, D., Hu, M.M., Zhang, M., Wu, X.X., Feng, L., Xu, W.H., Yang, Q., Zhong, X., Wei, J., Xu, Z.S., Zhang, H.X., Song, Z.M., Zhou, Q., Ye, W., Liu, Y., Li, S., Shu, H.B., 2018
- PASD1 promotes STAT3 activity and tumor growth by inhibiting TC45-mediated dephosphorylation of STAT3 in the nucleus., Xu, Z.S., Zhang, H.X., Zhang, Y.L., Liu, T.T., Ran, Y., Chen, L.T., Wang, Y.Y., Shu, H.B., 2016
Awards
- National Natural Science Foundation Youth Fund (2022-2024): Principal Investigator
- China Postdoctoral Science Foundation General Grant (2019-2021): Principal Investigator
- Fourth Batch of National Postdoctoral Innovative Talent Support Program (2019-2021): Principal Investigator
