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Wu Yan
Life Science
Sun Yat-Sen University
Guangdong
Language: Chinese, English
Tumor
Immunology
Macrophages
Metabolism
Reprogramming
Hepatocellular Carcinoma
Immune Escape
Microenvironment
Therapy
Targets
Areas of Focus
- Tumor Immunology
Work Experience
- 2011-08 to 2013-08: Postdoctoral Fellow, Sun Yat-sen University
- 2013-08 to 2014-01: Lecturer, Sun Yat-sen University
- 2014-01 to 2023-06: Associate Professor, Sun Yat-sen University
- 2023-06 to present: Professor, Sun Yat-sen University
Academic Background & Achievements
- 2002-09 to 2006-06: Bachelor of Science, Sun Yat-sen University
- 2006-09 to 2011-06: Doctor of Science, Sun Yat-sen University
- Achievement: Revealed new mechanisms of tumor immune escape and identified potential immunotherapy targets
Publications
- Downregulation of phosphoserine phosphatase potentiates tumor immune environments to enhance immune checkpoint blockade therapy., Peng ZP, Liu XC, Ruan YH, Jiang D, Huang AQ, Ning WR, Jiang ZZ, Zheng L, Wu Y., 2023
- Neutrophil extracellular traps induce tumor metastasis through dual effects on cancer and endothelial cells., Jiang ZZ, Peng ZP, Liu XC, Guo HF, Zhou MM, Jiang D, Ning WR, Huang YF, Zheng L, Wu Y., 2022
- Carbonic anhydrase XII mediates the survival and pro-metastatic functions of macrophages in human hepatocellular carcinoma., Ning WR, Jiang D, Liu XC, Huang YF, Peng ZP, Jiang ZZ, Kang T, Zhuang SM, Wu Y, Zheng L., 2022
- Type I IFNs repolarized a CD169+ macrophage population with anti-tumor potentials in hepatocellular carcinoma., Liao J, Zeng DN, Li JZ, Hua QM, Huang CX, Xu J, Wu C, Zheng L, Wen WP, Wu Y., 2022
- Glycolytic activation of monocytes regulates the accumulation and function of neutrophils in human hepatocellular carcinoma., Peng ZP, Jiang ZZ, Guo HF, Zhou MM, Huang YF, Ning WR, Huang JH, Zheng L, Wu Y., 2020
- Targeting adenosinergic pathway enhances the anti-tumor efficacy of sorafenib in hepatocellular carcinoma., Liao J, Zeng DN, Li JZ, Hua QM, Xiao Z, He C, Mao K, Zhu LY, Chu Y, Wen W, Zheng L, Wu Y., 2020
- Glycolytic activation of peritumoral monocytes fosters immune privilege via PFKFB3-PD-L1 axis in human hepatocellular carcinoma., Chen DP, Ning WR, Jiang ZZ, Peng ZP, Zhu LY, Zhuang SM, Kuang DM, Zheng L, Wu Y., 2019
- Peritumoral monocytes induce cancer cell autophagy to facilitate the progression of human hepatocellular carcinoma., Chen DP, Ning WR, Li XF, Wei Y, Lao XM, Wang JC, Wu Y, Zheng L., 2018
Awards
- 2019: Selected for Guangdong Province Special Support Plan for Young Top Talents
- 2014: National Natural Science Second Prize as the fourth contributor
