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Huabing Li
Basic Medical Sciences
Chongqing Medical University
Chongqing
Language: English, Chinese
Rna
Modifications
Epigenetics
Immunity
Immune Cells
Molecular Mechanisms
Physiological
Pathological
Regulation
Function
Areas of Focus
- RNA Modifications and Epigenetic Immunity
Work Experience
- 2024-present: Professor at Chongqing Medical University
- 2022.3-present: Distinguished Professor at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- 2020.5-present: Principal Investigator at State Key Laboratory of Oncogenes and Related Genes
- 2019.5-present: Researcher at Shanghai Jiao Tong University School of Medicine-Yale University Institute of Immunometabolism
- 2017.8-present: Senior Researcher at Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine; Adjunct Assistant Professor at Yale University School of Medicine
Academic Background & Achievements
- 2012-2017: Postdoctoral Researcher at Yale University
- 2011-2012: Postdoctoral Researcher at Rutgers University
- 2005-2011: Ph.D. from Rutgers University
- 2002-2005: M.S. from Nankai University
- 1999-2002: B.S. from Nankai University
Publications
- A Treg specific long non-coding RNA maintains immune-metabolic homeostasis in ageing liver., Ding C#, Yu Z#, Sefik E#, Zhou J#, Kaffe E, Wang G, Li B, Flavell RA, Hu W, Ye Y, Li HB*., 2023
- tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis., Liu Y#, Zhou J#, Li X#, Zhang X#, Shi J#, Wang X, Li H, Miao S, Chen H, He X, Dong L, Lee GR, Zhen J, Liu RJ, Su B, Ye Y, Flavell RA*, Yi C*, Wu Y*, Li HB*., 2022
- RNA m6A demethylase ALKBH5 regulates the development of γδ T cells., Ding C#, Xu H#, Yu Z#, Roulis M, Qu R, Zhou J, Oh J, Crawford J, Gao Y, Jackson R, Sefik E, Li S, Wei Z, Skadow M, Yin Z, Ouyang X, Wang L, Zou Q, Su B, Hu W*, Flavell R*, Li HB*., 2022
- DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion., Chen B#, Hu J#, Chen H, Bao R, Zhou Y, Zhan M*, Ye Y*, Li H*, Li HB*., 2022
- m6A mRNA modification maintains colonic epithelial cell homeostasis via NF-κb-mediated anti-apoptotic pathway., Zhang T#, Ding C#*, Chen H# Zhao J, Chen J, Chen B, Mao K, Hao Y, Roulis M, Xu H, Kluger Y, Zou Q, Ye Y, Zhan M*, Flavell RA*, Li HB*., 2022
- m6A Demethylase ALKBH5 Controls CD4+ T cell Pathogenicity and Promotes Autoimmunity., Zhou J#, Zhang X#, Hu J, Qu R, Yu Z, Xu H, Chen H, Yan L, Ding C, Zou Q, Ye Y, Wang Z, Flavell RA*, Li HB*., 2021
- Pooled CRISPR Screening Identifies m6A as a Positive Regulator of Macrophage Activation., Tong J#, Wang X#, Liu Y#, Ren X, Wang A, Chen Z, Yao J, Mao K, Liu T, Meng FL, Pan W, Zou Q, Zhou Y, Xia Q*, Flavell RA*, Zhu S*, Li HB*., 2021
- Cross-talk of Four Types of RNA Modification Writers Defines Tumor Microenvironment and Pharmacogenomic Landscape in Colorectal Cancer., Chen H#, Yao J#, Bao R, Dong Y, Zhang T, Du Y, Wang G, Ni D, Xun Z, Niu X, Ye Y*, Li HB*., 2021
- m6A mRNA methylation sustains Treg suppressive functions., Tong J#, Cao G#, Zhang T#, Sefik E, Vesely M, Broughton J, Zhu S, Li H, Li B, Chen L, Chang HY, Su B, Flavell RA*, Li HB*., 2018
- m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway., Li HB#*, Tong J#, Zhu S#, Batista PJ, Duffy EE, Zhao J, Bailis W, Cao G, Kroehling L, Chen Y, Wang G, Broughton JP, Chen YG, Kluger Y, Simon MD, Chang HY, Yin Z*, Flavell RA*., 2017
Awards
- 2023: National Science Fund for Distinguished Young Scholars
- 2022: Shanghai Health and Family Planning Commission Academic Leader
- 2018: National High-level Overseas Talent Youth Project
- 2018: Shanghai 'Oriental Scholar' Distinguished Professor
