Upload Avatar (500 x 500)
李华兵
Basic Medical Sciences
重庆医科大学
重庆
Language: 英语, 中文
Rna
修饰
表观遗传
免疫
免疫细胞
分子机制
生理
病理
调控
功能
Areas of Focus
- RNA修饰与表观免疫
Work Experience
- 2024-至今: 重庆医科大学教授
- 2022.3-至今: 上海交通大学医学院附属瑞金医院特聘教授
- 2020.5-至今: 癌基因与相关基因国家重点实验室研究组长
- 2019.5-至今: 上海交通大学医学院-耶鲁大学免疫代谢研究院研究员
- 2017.8-至今: 上海交通大学医学院上海市免疫学研究所资深研究员；耶鲁大学医学院客座助理教授
Academic Background & Achievements
- 2012-2017: 耶鲁大学博士后
- 2011-2012: 新泽西州立大学博士后
- 2005-2011: 新泽西州立大学博士
- 2002-2005: 南开大学硕士
- 1999-2002: 南开大学理学学士
Publications
- A Treg specific long non-coding RNA maintains immune-metabolic homeostasis in ageing liver., Ding C#, Yu Z#, Sefik E#, Zhou J#, Kaffe E, Wang G, Li B, Flavell RA, Hu W, Ye Y, Li HB*., 2023
- tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis., Liu Y#, Zhou J#, Li X#, Zhang X#, Shi J#, Wang X, Li H, Miao S, Chen H, He X, Dong L, Lee GR, Zhen J, Liu RJ, Su B, Ye Y, Flavell RA*, Yi C*, Wu Y*, Li HB*., 2022
- RNA m6A demethylase ALKBH5 regulates the development of γδ T cells., Ding C#, Xu H#, Yu Z#, Roulis M, Qu R, Zhou J, Oh J, Crawford J, Gao Y, Jackson R, Sefik E, Li S, Wei Z, Skadow M, Yin Z, Ouyang X, Wang L, Zou Q, Su B, Hu W*, Flavell R*, Li HB*., 2022
- DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion., Chen B#, Hu J#, Chen H, Bao R, Zhou Y, Zhan M*, Ye Y*, Li H*, Li HB*., 2022
- m6A mRNA modification maintains colonic epithelial cell homeostasis via NF-κb-mediated anti-apoptotic pathway., Zhang T#, Ding C#*, Chen H# Zhao J, Chen J, Chen B, Mao K, Hao Y, Roulis M, Xu H, Kluger Y, Zou Q, Ye Y, Zhan M*, Flavell RA*, Li HB*., 2022
- m6A Demethylase ALKBH5 Controls CD4+ T cell Pathogenicity and Promotes Autoimmunity., Zhou J#, Zhang X#, Hu J, Qu R, Yu Z, Xu H, Chen H, Yan L, Ding C, Zou Q, Ye Y, Wang Z, Flavell RA*, Li HB*., 2021
- Pooled CRISPR Screening Identifies m6A as a Positive Regulator of Macrophage Activation., Tong J#, Wang X#, Liu Y#, Ren X, Wang A, Chen Z, Yao J, Mao K, Liu T, Meng FL, Pan W, Zou Q, Zhou Y, Xia Q*, Flavell RA*, Zhu S*, Li HB*., 2021
- Cross-talk of Four Types of RNA Modification Writers Defines Tumor Microenvironment and Pharmacogenomic Landscape in Colorectal Cancer., Chen H#, Yao J#, Bao R, Dong Y, Zhang T, Du Y, Wang G, Ni D, Xun Z, Niu X, Ye Y*, Li HB*., 2021
- m6A mRNA methylation sustains Treg suppressive functions., Tong J#, Cao G#, Zhang T#, Sefik E, Vesely M, Broughton J, Zhu S, Li H, Li B, Chen L, Chang HY, Su B, Flavell RA*, Li HB*., 2018
- m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway., Li HB#*, Tong J#, Zhu S#, Batista PJ, Duffy EE, Zhao J, Bailis W, Cao G, Kroehling L, Chen Y, Wang G, Broughton JP, Chen YG, Kluger Y, Simon MD, Chang HY, Yin Z*, Flavell RA*., 2017
Awards
- 2023: 国家杰出青年科学基金
- 2022: 上海市卫生健康学科带头人
- 2018: 国家高层次海外人才青年项目
- 2018: 上海市“东方学者”特聘教授
