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Jian-Fei Pei
Life Science
China Medical University
Liaoning
Language: Chinese, English
Circadian Rhythms
Eukaryotic
Ttfl
Feedback Loop
Cardiovascular
Molecular Mechanisms
Aging
Redox Oscillation
Biological Rhythms
Gene Expression
Areas of Focus
- Transcription-Translation Feedback Loop (TTFL) in Eukaryotic Circadian Rhythms
- Molecular Mechanisms of Cardiovascular Events with 24-hour Rhythmicity
- Role of Redox Oscillation Rhythms in Mammalian Aging
Work Experience
- 2016-2021 - Chinese Academy of Medical Sciences, National Key Laboratory of Medical Molecular Biology - Researcher
- 2021-present - China Medical University, Department of Medical Genetics - Associate Researcher, Doctoral Supervisor, Independent PI
Academic Background & Achievements
- 2016 - PhD in Biochemistry and Molecular Biology: Tsinghua University
- Revealed a new theoretical model for biological rhythm regulation
- Proposed new strategies for treating aging-related cardiovascular diseases
- Identified molecular mechanisms of susceptibility to abdominal aortic aneurysm due to aging
Publications
- Diurnal oscillations of endogenous H2O2 sustained by p66Shc regulate circadian clocks, Jian-Fei Pei, Xun-Kai Li, Wen-Qi Li, Qian Gao, Yang Zhang, Xiao-Man Wang, Jia-Qi Fu, Shen-Shen Cui, Jia-Hua Qu, Xiang Zhao, De-Long Hao, Dapeng Ju, Na Liu, Kate S. Caroll, Jing Yang, Eric Erquan Zhang, Ji-Min Cao, Hou-Zao Chen, De-Pei Liu, 2019
- The paraoxonase gene cluster protects against abdominal aortic aneurysm formation, Yun-Fei Yan, Jian-Fei Pei, Yang Zhang, Ran Zhang, Fang Wang, Peng Gao, Zhu-Qin Zhang, Ting-Ting Wang, Zhi-Gang She, Hou-Zao Chen, De-Pei Liu, 2017
- Age-associated sirtuin 1 reduction in vascular smooth muscle links vascular senescence and inflammation to abdominal aortic aneurysm, Hou-Zao Chen, Fang Wang, Peng Gao, Jian-Fei Pei, Yue Liu, Ting-Ting Xu, Xiaoqiang Tang, Wen-Yan Fu, Jie Lu, Yun-Fei Yan, Xiao-Man Wang, Lei Han, Zhu-Qin Zhang, Ran Zhang, Ming-Hui Zou, De-Pei Liu, 2016
- Human paraoxonase gene cluster overexpression alleviates angiotensin II-induced cardiac hypertrophy in mice, Jian-Fei Pei, Yun-Fei Yan, Xiaoqiang Tang, Yang Zhang, Shen-Shen Cui, Zhu-Qin Zhang, Hou-Zao Chen, De-Pei Liu, 2016
Awards
- National Gold Award for Undergraduate Innovation and Entrepreneurship Competition
