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Weihao Shang
Life Science
China Medical University
Liaoning
Language: Chinese, Japanese, English
Nucleolar
Histone
Molecular Chaperones
Biological Significance
Homeostasis
Molecular Mechanisms
Chromosome Biology
Genetics
Cell Biology
Epigenetics
Areas of Focus
- Nucleolar Localization and Biological Significance of Histone Molecular Chaperones
- Molecular Mechanisms of Nucleolar and Intracellular Homeostasis
Work Experience
- Former Special Researcher at Japan Society for the Promotion of Science (JSPS)
- Former Special Researcher at National Institute of Genetics (NIG), Japan
- Assistant Professor at Osaka University, Japan
Academic Background & Achievements
- Doctor of Medicine: China Medical University
- Member of the Japanese Society for Molecular and Biochemical Research
- Member of the Japanese Cancer Society
Publications
- Association of M18BP1/KNL2 with CENP-A Nucleosome Is Essential for Centromere Formation in Non-mammalian Vertebrates, Hori T, Shang WH, Hara M, Ariyoshi M, Arimura Y, Fujita R, Kurumizaka H, Fukagawa T., 2017
- Acetylation of histone H4 Lysine 5 and 12 is required for CENP-A deposition into centromeres, Shang WH, Hori T, Westhorpe FG, Godek KM, Toyoda A, Misu S, Monma N, Ikeo K, Carroll CW, Takami Y, Fujiyama A, Kimura H, Straight AF, Fukagawa T., 2016
- Histone H4 Lys 20 monomethylation of the CENP-A nucleosome is essential for kinetochore assembly, Hori T, Shang WH, Toyoda A, Misu S, Monma N, Ikeo K, Molina O, Vargiu G, Fujiyama A, Kimura H, Earnshaw WC, Fukagawa T., 2014
- Chromosome engineering allows the efficient isolation of vertebrate neocentromeres, Shang WH, Hori T, Martins NM, Toyoda A, Misu S, Monma N, Hiratani I, Maeshima K, Ikeo K, Fujiyama A, Kimura H, Earnshaw WC, Fukagawa T., 2013
- The CCAN recruits CENP-A to the centromere and forms the structural core for kinetochore assembly, Hori T, Shang WH, Takeuchi K, Fukagawa T., 2013
- Chickens possess centromeres with both extended tandem repeats and short non-tandem-repetitive sequences, Shang WH, Hori T, Toyoda A, Kato J, Popendorf K, Sakakibara Y, Fujiyama A, Fukagawa T., 2010
Awards
- Research Grant from the Japan-China Medical Association
- Special Research Grant from the Japan Society for the Promotion of Science
- Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Culture, Sports, Science and Technology of Japan
