Professor | Donglai Wang | Asia Growth Partners

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Name	Donglai Wang
Contact Information	ndwang@ibms.pumc.edu.cn
Language ability	Chinese, English
Province	Beijing

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Name

Donglai Wang

Contact Information

ndwang@ibms.pumc.edu.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Peking Union Medical College
Faculty	Basic Medical Sciences
Academic Background & Achievements	2007 - Medical Bachelor's Degree: China Medical University 2012 - Doctor of Science: Peking University Health Science Center Selected for National Youth Talent Project
Work Experience	2012-09 to 2018-03 - Postdoctoral Training: UT MD Anderson Cancer Center and Columbia University 2018-04 to Present - Researcher and Group Leader: Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College
Awards	National Youth Talent Project High-end Scientific Talent Introduction Program

University/Lab Affiliation and Title

Peking Union Medical College

Faculty

Basic Medical Sciences

Academic Background & Achievements

2007 - Medical Bachelor's Degree: China Medical University
2012 - Doctor of Science: Peking University Health Science Center
Selected for National Youth Talent Project

Work Experience

2012-09 to 2018-03 - Postdoctoral Training: UT MD Anderson Cancer Center and Columbia University
2018-04 to Present - Researcher and Group Leader: Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College

Awards

National Youth Talent Project
High-end Scientific Talent Introduction Program

Areas of Focus	Post-translational Modifications and Tumorigenesis Epigenetic Modifications and Gene Transcription Regulation Biomolecular Interaction Networks
Publications	Interplay between Posttranslational Modifications and Liquid‒liquid Phase Separation in Tumors, Yan X, Zhang M, Wang D, 2024 Oncoprotein SET-associated Transcription Factor ZBTB11 Triggers Lung Cancer Metastasis, Xu W#, Yao H#, Wu Z, Yan X, Jiao Z, Liu Y, Zhang M, Wang D, 2024 Emerging Posttranslational Modifications and Their Roles in DNA Damage Response, Wu Z, Liu Y, Zhang M, Wang D, 2024 The Next Decade of SET: from an Oncoprotein to Beyond, Yao H, Zhang M, Wang D, 2023 Genome-wide CRISPR Screening Reveals ADCK3 as a Key Regulator in Sensitizing Endometrial Carcinoma Cells to MPA Therapy, Zhang Z, Zhang M, Zhou J, Wang D, 2023 A p53/LINC00324 Positive Feedback Loop Suppresses Tumor Growth by Counteracting SET-mediated Transcriptional Repression, Zhang L, Zhang J, Xuan X, Wu D, Yu J, Wang P, Yang X, Zhang J, Gan W, He M, Liu X-M, Zhou J, Wang D, Gu W, Li D, 2023 Coupled Deglycosylation-ubiquitination Cascade in Regulating PD-1 Degradation by MDM2, Wu Z, Cao Z, Yao H, Yan X, Xu W, Zhang M, Jiao Z, Zhang Z, Chen J, Liu Y, Zhang M, Wang D, 2023 Alternatively Mechanistic Insights into Acetylation in p53-mediated Transcriptional Regulation of Cancer Cell-intrinsic PD-1, Wen J, Yao H, Cao Z, Wang D, 2023 Targeting USP2 Regulation of VPRBP-mediated Degradation of p53 and PD-L1 for Cancer Therapy, Yi J, Tavana O, Li H, Wang D, Baer R, Gu W, 2023 The Repression of Oncoprotein SET by the Tumor Suppressor p53 Reveals a p53-SET-PP2A Feedback Loop for Cancer Therapy, Yao H#, Xu W#, Liu Y, Cao Z, Wen J, Zhang M, Wu Z, Yan X, Jiao Z, Zhang Z, Chen J, Zhang M, Zhu W-G, Wang D, 2023 抑癌蛋白p53乙酰化修饰的调控网络, 闫晓俊，文佳，王冬来, 2022 做客肿瘤细胞的免疫检查点分子：不在其位，也谋其政, 闫晓俊，王冬来, 2022 羧基末端乙酰化修饰调控抑癌蛋白p53转录特异性, 闫晓俊，徐文彬，王冬来, 2021 Deciphering the PTM Codes of the Tumor Suppressor p53, Wen J, Wang D, 2021 An Unexpected Role for p53 in Regulating Cancer Cell-intrinsic PD-1 by Acetylation, Cao Z, Kon N, Liu Y, Xu W, Wen J, Yao H, Zhang M, Wu Z, Yan X, Zhu W-G, Gu W,Wang D, 2021 抗肿瘤药物FTY720对p53依赖的基因转录调控, 姚涵，徐文彬，王冬来, 2021 Loss of SET Reveals both the p53-dependent and the p53-independent Functions in vivo, Kon N#, Wang D#, Gu W, 2019 Inhibition of Mdmx (Mdm4) in vivo Induces Anti-obesity Effects, Kon N#,Wang D#, Li T, Jiang L, Qiang L, Gu W, 2018 The 'Readers' of Unacetylated p53 Represent a New Class of Acidic Domain Proteins, Wang D, Kon N, Tavana O, Gu W, 2017 Acidic Domains: 'Converse Readers' for Acetylation Code, Wang D, Kon N, Gu W, 2016 Acetylation-regulated Interaction between p53 and SET Reveals a Widespread Regulatory Mode, Wang D#, Kon N#, Lasso G, Jiang L, Leng W, Zhu W-G, Qin J, Honig B, Gu W, 2016 Methylation of SUV39H1 by SET7/9 Results in Heterochromatin Relaxation and Genome Instability, Wang D#, Zhou J#, Liu X, Lu D, Shen C, Du Y, Wei F-Z, Song B, Lu X, Yu Y, Wang L, Zhao Y, Wang H, Yang Y, Yoshimitsu A, Zhang H, Zhu W-G, 2013 Methyltransferase Set7/9 Regulates p53 Activity by Interacting with Sirtuin 1 (SIRT1), Liu X#, Wang D#, Zhao Y, Tu B, Zheng Z, Wang L, Wang H, Gu W, Roeder RG, Zhu W-G, 2011

Areas of Focus

Post-translational Modifications and Tumorigenesis
Epigenetic Modifications and Gene Transcription Regulation
Biomolecular Interaction Networks

Publications

Interplay between Posttranslational Modifications and Liquid‒liquid Phase Separation in Tumors, Yan X, Zhang M, Wang D*, 2024
Oncoprotein SET-associated Transcription Factor ZBTB11 Triggers Lung Cancer Metastasis, Xu W#, Yao H#, Wu Z, Yan X, Jiao Z, Liu Y, Zhang M, Wang D*, 2024
Emerging Posttranslational Modifications and Their Roles in DNA Damage Response, Wu Z, Liu Y, Zhang M, Wang D*, 2024
The Next Decade of SET: from an Oncoprotein to Beyond, Yao H, Zhang M, Wang D*, 2023
Genome-wide CRISPR Screening Reveals ADCK3 as a Key Regulator in Sensitizing Endometrial Carcinoma Cells to MPA Therapy, Zhang Z, Zhang M, Zhou J*, Wang D*, 2023
A p53/LINC00324 Positive Feedback Loop Suppresses Tumor Growth by Counteracting SET-mediated Transcriptional Repression, Zhang L, Zhang J, Xuan X, Wu D, Yu J, Wang P, Yang X, Zhang J, Gan W, He M, Liu X-M, Zhou J, Wang D, Gu W, Li D*, 2023
Coupled Deglycosylation-ubiquitination Cascade in Regulating PD-1 Degradation by MDM2, Wu Z, Cao Z, Yao H, Yan X, Xu W, Zhang M, Jiao Z, Zhang Z, Chen J, Liu Y, Zhang M, Wang D*, 2023
Alternatively Mechanistic Insights into Acetylation in p53-mediated Transcriptional Regulation of Cancer Cell-intrinsic PD-1, Wen J, Yao H, Cao Z, Wang D*, 2023
Targeting USP2 Regulation of VPRBP-mediated Degradation of p53 and PD-L1 for Cancer Therapy, Yi J, Tavana O, Li H, Wang D, Baer R, Gu W*, 2023
The Repression of Oncoprotein SET by the Tumor Suppressor p53 Reveals a p53-SET-PP2A Feedback Loop for Cancer Therapy, Yao H#, Xu W#, Liu Y, Cao Z, Wen J, Zhang M, Wu Z, Yan X, Jiao Z, Zhang Z, Chen J, Zhang M, Zhu W-G*, Wang D*, 2023
抑癌蛋白p53乙酰化修饰的调控网络, 闫晓俊，文佳，王冬来*, 2022
做客肿瘤细胞的免疫检查点分子：不在其位，也谋其政, 闫晓俊，王冬来*, 2022
羧基末端乙酰化修饰调控抑癌蛋白p53转录特异性, 闫晓俊，徐文彬，王冬来*, 2021
Deciphering the PTM Codes of the Tumor Suppressor p53, Wen J, Wang D*, 2021
An Unexpected Role for p53 in Regulating Cancer Cell-intrinsic PD-1 by Acetylation, Cao Z, Kon N, Liu Y, Xu W, Wen J, Yao H, Zhang M, Wu Z, Yan X, Zhu W-G, Gu W*,Wang D*, 2021
抗肿瘤药物FTY720对p53依赖的基因转录调控, 姚涵，徐文彬，王冬来*, 2021
Loss of SET Reveals both the p53-dependent and the p53-independent Functions in vivo, Kon N#, Wang D#, Gu W*, 2019
Inhibition of Mdmx (Mdm4) in vivo Induces Anti-obesity Effects, Kon N#,Wang D#, Li T, Jiang L, Qiang L*, Gu W*, 2018
The 'Readers' of Unacetylated p53 Represent a New Class of Acidic Domain Proteins, Wang D, Kon N, Tavana O, Gu W*, 2017
Acidic Domains: 'Converse Readers' for Acetylation Code, Wang D, Kon N, Gu W*, 2016
Acetylation-regulated Interaction between p53 and SET Reveals a Widespread Regulatory Mode, Wang D#, Kon N#, Lasso G, Jiang L, Leng W, Zhu W-G, Qin J, Honig B, Gu W*, 2016
Methylation of SUV39H1 by SET7/9 Results in Heterochromatin Relaxation and Genome Instability, Wang D#, Zhou J#, Liu X, Lu D, Shen C, Du Y, Wei F-Z, Song B, Lu X, Yu Y, Wang L, Zhao Y, Wang H, Yang Y, Yoshimitsu A, Zhang H, Zhu W-G*, 2013
Methyltransferase Set7/9 Regulates p53 Activity by Interacting with Sirtuin 1 (SIRT1), Liu X#, Wang D#, Zhao Y, Tu B, Zheng Z, Wang L, Wang H, Gu W, Roeder RG*, Zhu W-G*, 2011

Post-Translational Modifications Tumorigenesis Epigenetic Modifications Gene Transcription Biomolecular Networks Protein Interactions Cancer Research Genetic Regulation Molecular Biology Cell Signaling

Genze Shao - Peking University

Shi Feng - Central South University

Zuping Zhang - Central South University

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