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王冬来
Basic Medical Sciences
北京协和医学院
北京
Language: 中文, 英语
蛋白质翻译后修饰
肿瘤发生
表观遗传修饰
基因转录
生物大分子网络
蛋白质相互作用
癌症研究
遗传调控
分子生物学
细胞信号
Areas of Focus
- 蛋白质翻译后修饰与肿瘤发生
- 表观遗传修饰与基因转录调控
- 生物大分子相互作用网络
Work Experience
- 2012-09 至 2018-03 - 博士后训练：UT MD安德森癌症中心和哥伦比亚大学
- 2018-04 至今 - 研究员和课题组长：中国医学科学院基础医学研究所&北京协和医学院
Academic Background & Achievements
- 2007 - 医学学士学位：中国医科大学
- 2012 - 理学博士学位：北京大学医学部
- 入选国家级青年人才项目
Publications
- Interplay between Posttranslational Modifications and Liquid‒liquid Phase Separation in Tumors, Yan X, Zhang M, Wang D*, 2024
- Oncoprotein SET-associated Transcription Factor ZBTB11 Triggers Lung Cancer Metastasis, Xu W#, Yao H#, Wu Z, Yan X, Jiao Z, Liu Y, Zhang M, Wang D*, 2024
- Emerging Posttranslational Modifications and Their Roles in DNA Damage Response, Wu Z, Liu Y, Zhang M, Wang D*, 2024
- The Next Decade of SET: from an Oncoprotein to Beyond, Yao H, Zhang M, Wang D*, 2023
- Genome-wide CRISPR Screening Reveals ADCK3 as a Key Regulator in Sensitizing Endometrial Carcinoma Cells to MPA Therapy, Zhang Z, Zhang M, Zhou J*, Wang D*, 2023
- A p53/LINC00324 Positive Feedback Loop Suppresses Tumor Growth by Counteracting SET-mediated Transcriptional Repression, Zhang L, Zhang J, Xuan X, Wu D, Yu J, Wang P, Yang X, Zhang J, Gan W, He M, Liu X-M, Zhou J, Wang D, Gu W, Li D*, 2023
- Coupled Deglycosylation-ubiquitination Cascade in Regulating PD-1 Degradation by MDM2, Wu Z, Cao Z, Yao H, Yan X, Xu W, Zhang M, Jiao Z, Zhang Z, Chen J, Liu Y, Zhang M, Wang D*, 2023
- Alternatively Mechanistic Insights into Acetylation in p53-mediated Transcriptional Regulation of Cancer Cell-intrinsic PD-1, Wen J, Yao H, Cao Z, Wang D*, 2023
- Targeting USP2 Regulation of VPRBP-mediated Degradation of p53 and PD-L1 for Cancer Therapy, Yi J, Tavana O, Li H, Wang D, Baer R, Gu W*, 2023
- The Repression of Oncoprotein SET by the Tumor Suppressor p53 Reveals a p53-SET-PP2A Feedback Loop for Cancer Therapy, Yao H#, Xu W#, Liu Y, Cao Z, Wen J, Zhang M, Wu Z, Yan X, Jiao Z, Zhang Z, Chen J, Zhang M, Zhu W-G*, Wang D*, 2023
- 抑癌蛋白p53乙酰化修饰的调控网络, 闫晓俊，文佳，王冬来*, 2022
- 做客肿瘤细胞的免疫检查点分子：不在其位，也谋其政, 闫晓俊，王冬来*, 2022
- 羧基末端乙酰化修饰调控抑癌蛋白p53转录特异性, 闫晓俊，徐文彬，王冬来*, 2021
- Deciphering the PTM Codes of the Tumor Suppressor p53, Wen J, Wang D*, 2021
- An Unexpected Role for p53 in Regulating Cancer Cell-intrinsic PD-1 by Acetylation, Cao Z, Kon N, Liu Y, Xu W, Wen J, Yao H, Zhang M, Wu Z, Yan X, Zhu W-G, Gu W*,Wang D*, 2021
- 抗肿瘤药物FTY720对p53依赖的基因转录调控, 姚涵，徐文彬，王冬来*, 2021
- Loss of SET Reveals both the p53-dependent and the p53-independent Functions in vivo, Kon N#, Wang D#, Gu W*, 2019
- Inhibition of Mdmx (Mdm4) in vivo Induces Anti-obesity Effects, Kon N#,Wang D#, Li T, Jiang L, Qiang L*, Gu W*, 2018
- The 'Readers' of Unacetylated p53 Represent a New Class of Acidic Domain Proteins, Wang D, Kon N, Tavana O, Gu W*, 2017
- Acidic Domains: 'Converse Readers' for Acetylation Code, Wang D, Kon N, Gu W*, 2016
- Acetylation-regulated Interaction between p53 and SET Reveals a Widespread Regulatory Mode, Wang D#, Kon N#, Lasso G, Jiang L, Leng W, Zhu W-G, Qin J, Honig B, Gu W*, 2016
- Methylation of SUV39H1 by SET7/9 Results in Heterochromatin Relaxation and Genome Instability, Wang D#, Zhou J#, Liu X, Lu D, Shen C, Du Y, Wei F-Z, Song B, Lu X, Yu Y, Wang L, Zhao Y, Wang H, Yang Y, Yoshimitsu A, Zhang H, Zhu W-G*, 2013
- Methyltransferase Set7/9 Regulates p53 Activity by Interacting with Sirtuin 1 (SIRT1), Liu X#, Wang D#, Zhao Y, Tu B, Zheng Z, Wang L, Wang H, Gu W, Roeder RG*, Zhu W-G*, 2011
Awards
- 国家级青年人才项目
- 高端科技人才引进专项支持计划
