Professor | 王冬来 | 数字化转型顾问

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Name	王冬来
Contact Information	ndwang@ibms.pumc.edu.cn
Language ability	中文, 英语
Province	北京

Upload Avatar (500 x 500)

Name

王冬来

Contact Information

ndwang@ibms.pumc.edu.cn

Language ability

中文, 英语

Province

北京

University/Lab Affiliation and Title	北京协和医学院
Faculty	Basic Medical Sciences
Academic Background & Achievements	2007 - 医学学士学位：中国医科大学 2012 - 理学博士学位：北京大学医学部入选国家级青年人才项目
Work Experience	2012-09 至 2018-03 - 博士后训练：UT MD安德森癌症中心和哥伦比亚大学 2018-04 至今 - 研究员和课题组长：中国医学科学院基础医学研究所&北京协和医学院
Awards	国家级青年人才项目高端科技人才引进专项支持计划

University/Lab Affiliation and Title

北京协和医学院

Faculty

Basic Medical Sciences

Academic Background & Achievements

2007 - 医学学士学位：中国医科大学
2012 - 理学博士学位：北京大学医学部
入选国家级青年人才项目

Work Experience

2012-09 至 2018-03 - 博士后训练：UT MD安德森癌症中心和哥伦比亚大学
2018-04 至今 - 研究员和课题组长：中国医学科学院基础医学研究所&北京协和医学院

Awards

国家级青年人才项目
高端科技人才引进专项支持计划

Areas of Focus	蛋白质翻译后修饰与肿瘤发生表观遗传修饰与基因转录调控生物大分子相互作用网络
Publications	Interplay between Posttranslational Modifications and Liquid‒liquid Phase Separation in Tumors, Yan X, Zhang M, Wang D, 2024 Oncoprotein SET-associated Transcription Factor ZBTB11 Triggers Lung Cancer Metastasis, Xu W#, Yao H#, Wu Z, Yan X, Jiao Z, Liu Y, Zhang M, Wang D, 2024 Emerging Posttranslational Modifications and Their Roles in DNA Damage Response, Wu Z, Liu Y, Zhang M, Wang D, 2024 The Next Decade of SET: from an Oncoprotein to Beyond, Yao H, Zhang M, Wang D, 2023 Genome-wide CRISPR Screening Reveals ADCK3 as a Key Regulator in Sensitizing Endometrial Carcinoma Cells to MPA Therapy, Zhang Z, Zhang M, Zhou J, Wang D, 2023 A p53/LINC00324 Positive Feedback Loop Suppresses Tumor Growth by Counteracting SET-mediated Transcriptional Repression, Zhang L, Zhang J, Xuan X, Wu D, Yu J, Wang P, Yang X, Zhang J, Gan W, He M, Liu X-M, Zhou J, Wang D, Gu W, Li D, 2023 Coupled Deglycosylation-ubiquitination Cascade in Regulating PD-1 Degradation by MDM2, Wu Z, Cao Z, Yao H, Yan X, Xu W, Zhang M, Jiao Z, Zhang Z, Chen J, Liu Y, Zhang M, Wang D, 2023 Alternatively Mechanistic Insights into Acetylation in p53-mediated Transcriptional Regulation of Cancer Cell-intrinsic PD-1, Wen J, Yao H, Cao Z, Wang D, 2023 Targeting USP2 Regulation of VPRBP-mediated Degradation of p53 and PD-L1 for Cancer Therapy, Yi J, Tavana O, Li H, Wang D, Baer R, Gu W, 2023 The Repression of Oncoprotein SET by the Tumor Suppressor p53 Reveals a p53-SET-PP2A Feedback Loop for Cancer Therapy, Yao H#, Xu W#, Liu Y, Cao Z, Wen J, Zhang M, Wu Z, Yan X, Jiao Z, Zhang Z, Chen J, Zhang M, Zhu W-G, Wang D, 2023 抑癌蛋白p53乙酰化修饰的调控网络, 闫晓俊，文佳，王冬来, 2022 做客肿瘤细胞的免疫检查点分子：不在其位，也谋其政, 闫晓俊，王冬来, 2022 羧基末端乙酰化修饰调控抑癌蛋白p53转录特异性, 闫晓俊，徐文彬，王冬来, 2021 Deciphering the PTM Codes of the Tumor Suppressor p53, Wen J, Wang D, 2021 An Unexpected Role for p53 in Regulating Cancer Cell-intrinsic PD-1 by Acetylation, Cao Z, Kon N, Liu Y, Xu W, Wen J, Yao H, Zhang M, Wu Z, Yan X, Zhu W-G, Gu W,Wang D, 2021 抗肿瘤药物FTY720对p53依赖的基因转录调控, 姚涵，徐文彬，王冬来, 2021 Loss of SET Reveals both the p53-dependent and the p53-independent Functions in vivo, Kon N#, Wang D#, Gu W, 2019 Inhibition of Mdmx (Mdm4) in vivo Induces Anti-obesity Effects, Kon N#,Wang D#, Li T, Jiang L, Qiang L, Gu W, 2018 The 'Readers' of Unacetylated p53 Represent a New Class of Acidic Domain Proteins, Wang D, Kon N, Tavana O, Gu W, 2017 Acidic Domains: 'Converse Readers' for Acetylation Code, Wang D, Kon N, Gu W, 2016 Acetylation-regulated Interaction between p53 and SET Reveals a Widespread Regulatory Mode, Wang D#, Kon N#, Lasso G, Jiang L, Leng W, Zhu W-G, Qin J, Honig B, Gu W, 2016 Methylation of SUV39H1 by SET7/9 Results in Heterochromatin Relaxation and Genome Instability, Wang D#, Zhou J#, Liu X, Lu D, Shen C, Du Y, Wei F-Z, Song B, Lu X, Yu Y, Wang L, Zhao Y, Wang H, Yang Y, Yoshimitsu A, Zhang H, Zhu W-G, 2013 Methyltransferase Set7/9 Regulates p53 Activity by Interacting with Sirtuin 1 (SIRT1), Liu X#, Wang D#, Zhao Y, Tu B, Zheng Z, Wang L, Wang H, Gu W, Roeder RG, Zhu W-G, 2011

Areas of Focus

蛋白质翻译后修饰与肿瘤发生
表观遗传修饰与基因转录调控
生物大分子相互作用网络

Publications

Interplay between Posttranslational Modifications and Liquid‒liquid Phase Separation in Tumors, Yan X, Zhang M, Wang D*, 2024
Oncoprotein SET-associated Transcription Factor ZBTB11 Triggers Lung Cancer Metastasis, Xu W#, Yao H#, Wu Z, Yan X, Jiao Z, Liu Y, Zhang M, Wang D*, 2024
Emerging Posttranslational Modifications and Their Roles in DNA Damage Response, Wu Z, Liu Y, Zhang M, Wang D*, 2024
The Next Decade of SET: from an Oncoprotein to Beyond, Yao H, Zhang M, Wang D*, 2023
Genome-wide CRISPR Screening Reveals ADCK3 as a Key Regulator in Sensitizing Endometrial Carcinoma Cells to MPA Therapy, Zhang Z, Zhang M, Zhou J*, Wang D*, 2023
A p53/LINC00324 Positive Feedback Loop Suppresses Tumor Growth by Counteracting SET-mediated Transcriptional Repression, Zhang L, Zhang J, Xuan X, Wu D, Yu J, Wang P, Yang X, Zhang J, Gan W, He M, Liu X-M, Zhou J, Wang D, Gu W, Li D*, 2023
Coupled Deglycosylation-ubiquitination Cascade in Regulating PD-1 Degradation by MDM2, Wu Z, Cao Z, Yao H, Yan X, Xu W, Zhang M, Jiao Z, Zhang Z, Chen J, Liu Y, Zhang M, Wang D*, 2023
Alternatively Mechanistic Insights into Acetylation in p53-mediated Transcriptional Regulation of Cancer Cell-intrinsic PD-1, Wen J, Yao H, Cao Z, Wang D*, 2023
Targeting USP2 Regulation of VPRBP-mediated Degradation of p53 and PD-L1 for Cancer Therapy, Yi J, Tavana O, Li H, Wang D, Baer R, Gu W*, 2023
The Repression of Oncoprotein SET by the Tumor Suppressor p53 Reveals a p53-SET-PP2A Feedback Loop for Cancer Therapy, Yao H#, Xu W#, Liu Y, Cao Z, Wen J, Zhang M, Wu Z, Yan X, Jiao Z, Zhang Z, Chen J, Zhang M, Zhu W-G*, Wang D*, 2023
抑癌蛋白p53乙酰化修饰的调控网络, 闫晓俊，文佳，王冬来*, 2022
做客肿瘤细胞的免疫检查点分子：不在其位，也谋其政, 闫晓俊，王冬来*, 2022
羧基末端乙酰化修饰调控抑癌蛋白p53转录特异性, 闫晓俊，徐文彬，王冬来*, 2021
Deciphering the PTM Codes of the Tumor Suppressor p53, Wen J, Wang D*, 2021
An Unexpected Role for p53 in Regulating Cancer Cell-intrinsic PD-1 by Acetylation, Cao Z, Kon N, Liu Y, Xu W, Wen J, Yao H, Zhang M, Wu Z, Yan X, Zhu W-G, Gu W*,Wang D*, 2021
抗肿瘤药物FTY720对p53依赖的基因转录调控, 姚涵，徐文彬，王冬来*, 2021
Loss of SET Reveals both the p53-dependent and the p53-independent Functions in vivo, Kon N#, Wang D#, Gu W*, 2019
Inhibition of Mdmx (Mdm4) in vivo Induces Anti-obesity Effects, Kon N#,Wang D#, Li T, Jiang L, Qiang L*, Gu W*, 2018
The 'Readers' of Unacetylated p53 Represent a New Class of Acidic Domain Proteins, Wang D, Kon N, Tavana O, Gu W*, 2017
Acidic Domains: 'Converse Readers' for Acetylation Code, Wang D, Kon N, Gu W*, 2016
Acetylation-regulated Interaction between p53 and SET Reveals a Widespread Regulatory Mode, Wang D#, Kon N#, Lasso G, Jiang L, Leng W, Zhu W-G, Qin J, Honig B, Gu W*, 2016
Methylation of SUV39H1 by SET7/9 Results in Heterochromatin Relaxation and Genome Instability, Wang D#, Zhou J#, Liu X, Lu D, Shen C, Du Y, Wei F-Z, Song B, Lu X, Yu Y, Wang L, Zhao Y, Wang H, Yang Y, Yoshimitsu A, Zhang H, Zhu W-G*, 2013
Methyltransferase Set7/9 Regulates p53 Activity by Interacting with Sirtuin 1 (SIRT1), Liu X#, Wang D#, Zhao Y, Tu B, Zheng Z, Wang L, Wang H, Gu W, Roeder RG*, Zhu W-G*, 2011

蛋白质翻译后修饰肿瘤发生表观遗传修饰基因转录生物大分子网络蛋白质相互作用癌症研究遗传调控分子生物学细胞信号

邵根泽 - 北京大学

张晓伟 - 北京大学

张君 - 北京大学

Area of Focus
炎症 | 免疫学 | 癌症 | 调控 | 肿瘤 | 免疫反应 | 细胞信号 | 分子生物学 | 发病机制 | 治疗

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