Professor | Jun Li | Asia Growth Partners

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Name	Jun Li
Contact Information	jun_li@ibms.pumc.edu.cn
Language ability	English, Chinese
Province	Beijing

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Name

Jun Li

Contact Information

jun_li@ibms.pumc.edu.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	Peking Union Medical College
Faculty	Basic Medical Sciences
Academic Background & Achievements	Bachelor's Degree: Peking University Health Science Center, Basic Medicine 2010 - PhD in Biochemistry and Biophysics: Texas A&M University 2018 - Selected for the 'Outstanding Young Talent' program by the Chinese Academy of Medical Sciences
Work Experience	2010-2018 - Harvard Medical School, Postdoctoral Research under David Sinclair 2018-present - Chinese Academy of Medical Sciences, Researcher and Group Leader
Awards	2018: Selected for the 'Outstanding Young Talent' program by the Chinese Academy of Medical Sciences

University/Lab Affiliation and Title

Peking Union Medical College

Faculty

Basic Medical Sciences

Academic Background & Achievements

Bachelor's Degree: Peking University Health Science Center, Basic Medicine
2010 - PhD in Biochemistry and Biophysics: Texas A&M University
2018 - Selected for the 'Outstanding Young Talent' program by the Chinese Academy of Medical Sciences

Work Experience

2010-2018 - Harvard Medical School, Postdoctoral Research under David Sinclair
2018-present - Chinese Academy of Medical Sciences, Researcher and Group Leader

Awards

2018: Selected for the 'Outstanding Young Talent' program by the Chinese Academy of Medical Sciences

Areas of Focus	Molecular mechanisms of aging Anti-aging interventions
Publications	DMT1 differentially regulates mitochondrial complex activities to reduce glutathione loss and mitigate ferroptosis., Qing Tan, Xiaoqian Zhang, Shuxiang Li, Wenbin Liu, Jiaqi Yan, Siqi Wang, Feng Cui, Dan Li, Jun Li, 2023 ML216 Prevents DNA Damage-Induced Senescence by Modulating DBC1–BLM Interaction., Feng Cui, Xueying Han, Xiaoqian Zhang, Siqi Wang, Na Liang, Qing Tan, Wuga Sha, Jun Li, 2023 Dynamic aging: channeled through microenvironment., Qing Tan, Na Liang, Xiaoqian Zhang, Jun Li, 2021 A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks., Evandro F. Fang, Chenglong Xie, Joseph A. Schenkel, Chenkai Wu, Qian Long, Honghua Cui, Yahyah Aman, Johannes Frank, Jing Liao, Huachun Zou, Ninie Y. Wang, Jing Wu, Xiaoting Liu, Tao Li, Yuan Fang, Zhangming Niu, Guang Yang, Jiangshui Hong, Qian Wang, Guobing Chen, Jun Li, Hou-Zao Chen, Lin Kang, Huanxing Su, Brian C. Gilmour, Xinqiang Zhu, Hong Jiang, Na He, Jun Tao, Sean Xiao Leng, Tanjun Tong, Jean Woo, 2020 Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage., Emma Bolderson, Joshua T Burgess, Jun Li, Neha S Gandhi, Didier Boucher, Laura V Croft, Samuel Beard, Jennifer J Plowman, Amila Suraweera, Mark N Adams, Ali Naqi, Shu-Dong Zhang, David A Sinclair, Kenneth J O'Byrne, Derek J Richard, 2019 A conserved NAD+ binding pocket that regulates protein-protein interactions during aging., Jun Li, Michael S. Bonkowski, Sébastien Moniot, Dapeng Zhang, Basil P. Hubbard, Alvin J.Y. Ling, Luis A. Rajman, Bo Qin, Zhenkun Lou, Vera Gorbunova, L. Aravind, Clemens Steegborn and David A. Sinclair, 2017 NAD+ replenishment significantly improves outcomes in Ataxia telangiectasia models via mitophagy and DNA repair., Evandro Fei Fang, Henok Kassahun, Deborah L. Croteau, Morten Scheibye-Knudsen, Huiming Lu, Raghavendra A. Shamanna, Sumana Kalyanasundaram, Ravi Chand Bollineni, Mark A. Wilson, Wendy B. Iser, Bradley N. Wollman, Marya Morevati, Jun Li, Jesse S. Kerr, Qiping Lu, Tyler B. Waltz, Jane Tian, David A. Sinclair, Mark P. Mattson, Hilde Nilsen, Vilhelm A. Bohr, 2016 Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism., Hubbard BP, Loh C, Gomes AP, Li J, Lu Q, Doyle TL, Disch JS, Armour SM, Ellis JL, Vlasuk GP, Sinclair DA, 2013 Evidence for a common mechanism of Sirt1 activation by small molecules., Hubbard, P., Gomes, A., Dai, H., Li, J., Case, A., Considine, T., Riera, T., Lee, J., Yen, ES, Lamming, D., Pentelute, B., Schuman, E., Stevens, L., Ling, A., Armour, S., Michan, S., Zhao, H., Jiang, Y., Sweitzer, S., Blum, C., Disch, J., Ng, PY., Howitz, K., Hamaro, Y., Moss, J., Perni, R., Ellis, J., Vlasuk, G. and Sinclair, D.A, 2013 Regulation of Phenylalanine Hydroxylase: Conformational changes upon phosphorylation detected by H/D exchange and mass spectrometry., Jun Li and Paul Fitzpatrick, 2013 Direct evidence for a phenylalanine site in the regulatory domain of phenylalanine hydroxylase., Jun Li, Udayar Ilangovan, Susan Daubner, Andy Hinck, Paul Fitzpatrick, 2011 Regulation of phenylalanine Hydroxylase: Conformational changes upon phenylalanine binding detected by H/D exchange and mass spectrometry., Jun Li, Larry Dangott, and Paul Fitzpatrick, 2010 Characterization of metal ligand mutants of phenylalanine hydroxylase: Insights into the plasticity of a 2-histidine-1-carboxylate triad., Jun Li and Paul Fitzpatrick, 2008

Areas of Focus

Molecular mechanisms of aging
Anti-aging interventions

Publications

DMT1 differentially regulates mitochondrial complex activities to reduce glutathione loss and mitigate ferroptosis., Qing Tan, Xiaoqian Zhang, Shuxiang Li, Wenbin Liu, Jiaqi Yan, Siqi Wang, Feng Cui, Dan Li, Jun Li*, 2023
ML216 Prevents DNA Damage-Induced Senescence by Modulating DBC1–BLM Interaction., Feng Cui, Xueying Han, Xiaoqian Zhang, Siqi Wang, Na Liang, Qing Tan, Wuga Sha, Jun Li*, 2023
Dynamic aging: channeled through microenvironment., Qing Tan, Na Liang, Xiaoqian Zhang, Jun Li*, 2021
A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks., Evandro F. Fang, Chenglong Xie, Joseph A. Schenkel, Chenkai Wu, Qian Long, Honghua Cui, Yahyah Aman, Johannes Frank, Jing Liao, Huachun Zou, Ninie Y. Wang, Jing Wu, Xiaoting Liu, Tao Li, Yuan Fang, Zhangming Niu, Guang Yang, Jiangshui Hong, Qian Wang, Guobing Chen, Jun Li, Hou-Zao Chen, Lin Kang, Huanxing Su, Brian C. Gilmour, Xinqiang Zhu, Hong Jiang, Na He, Jun Tao, Sean Xiao Leng, Tanjun Tong, Jean Woo*, 2020
Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage., Emma Bolderson*, Joshua T Burgess, Jun Li, Neha S Gandhi, Didier Boucher, Laura V Croft, Samuel Beard, Jennifer J Plowman, Amila Suraweera, Mark N Adams, Ali Naqi, Shu-Dong Zhang, David A Sinclair, Kenneth J O'Byrne, Derek J Richard*, 2019
A conserved NAD+ binding pocket that regulates protein-protein interactions during aging., Jun Li, Michael S. Bonkowski, Sébastien Moniot, Dapeng Zhang, Basil P. Hubbard, Alvin J.Y. Ling, Luis A. Rajman, Bo Qin, Zhenkun Lou, Vera Gorbunova, L. Aravind, Clemens Steegborn and David A. Sinclair*, 2017
NAD+ replenishment significantly improves outcomes in Ataxia telangiectasia models via mitophagy and DNA repair., Evandro Fei Fang, Henok Kassahun, Deborah L. Croteau, Morten Scheibye-Knudsen, Huiming Lu, Raghavendra A. Shamanna, Sumana Kalyanasundaram, Ravi Chand Bollineni, Mark A. Wilson, Wendy B. Iser, Bradley N. Wollman, Marya Morevati, Jun Li, Jesse S. Kerr, Qiping Lu, Tyler B. Waltz, Jane Tian, David A. Sinclair, Mark P. Mattson, Hilde Nilsen, Vilhelm A. Bohr*, 2016
Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism., Hubbard BP, Loh C, Gomes AP, Li J, Lu Q, Doyle TL, Disch JS, Armour SM, Ellis JL, Vlasuk GP, Sinclair DA*, 2013
Evidence for a common mechanism of Sirt1 activation by small molecules., Hubbard, P., Gomes, A., Dai, H., Li, J., Case, A., Considine, T., Riera, T., Lee, J., Yen, ES, Lamming, D., Pentelute, B., Schuman, E., Stevens, L., Ling, A., Armour, S., Michan, S., Zhao, H., Jiang, Y., Sweitzer, S., Blum, C., Disch, J., Ng, PY., Howitz, K., Hamaro, Y., Moss, J., Perni, R., Ellis, J., Vlasuk, G. and Sinclair, D.A*, 2013
Regulation of Phenylalanine Hydroxylase: Conformational changes upon phosphorylation detected by H/D exchange and mass spectrometry., Jun Li and Paul Fitzpatrick*, 2013
Direct evidence for a phenylalanine site in the regulatory domain of phenylalanine hydroxylase., Jun Li, Udayar Ilangovan, Susan Daubner, Andy Hinck, Paul Fitzpatrick*, 2011
Regulation of phenylalanine Hydroxylase: Conformational changes upon phenylalanine binding detected by H/D exchange and mass spectrometry., Jun Li, Larry Dangott, and Paul Fitzpatrick*, 2010
Characterization of metal ligand mutants of phenylalanine hydroxylase: Insights into the plasticity of a 2-histidine-1-carboxylate triad., Jun Li and Paul Fitzpatrick*, 2008

Nad Metabolism Cellular Senescence Dna Damage Dna Repair Aging Anti-Aging Molecular Biology Biochemistry Intervention Research

Guoheng Xu - Peking University

Genze Shao - Peking University

Tanjun Tong - Peking University

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