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Jun Li
Basic Medical Sciences
Peking Union Medical College
Beijing
Language: English, Chinese
Nad Metabolism
Cellular Senescence
Dna Damage
Dna Repair
Aging
Anti-Aging
Molecular Biology
Biochemistry
Intervention
Research
Areas of Focus
- Molecular mechanisms of aging
- Anti-aging interventions
Work Experience
- 2010-2018 - Harvard Medical School, Postdoctoral Research under David Sinclair
- 2018-present - Chinese Academy of Medical Sciences, Researcher and Group Leader
Academic Background & Achievements
- Bachelor's Degree: Peking University Health Science Center, Basic Medicine
- 2010 - PhD in Biochemistry and Biophysics: Texas A&M University
- 2018 - Selected for the 'Outstanding Young Talent' program by the Chinese Academy of Medical Sciences
Publications
- DMT1 differentially regulates mitochondrial complex activities to reduce glutathione loss and mitigate ferroptosis., Qing Tan, Xiaoqian Zhang, Shuxiang Li, Wenbin Liu, Jiaqi Yan, Siqi Wang, Feng Cui, Dan Li, Jun Li*, 2023
- ML216 Prevents DNA Damage-Induced Senescence by Modulating DBC1–BLM Interaction., Feng Cui, Xueying Han, Xiaoqian Zhang, Siqi Wang, Na Liang, Qing Tan, Wuga Sha, Jun Li*, 2023
- Dynamic aging: channeled through microenvironment., Qing Tan, Na Liang, Xiaoqian Zhang, Jun Li*, 2021
- A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks., Evandro F. Fang, Chenglong Xie, Joseph A. Schenkel, Chenkai Wu, Qian Long, Honghua Cui, Yahyah Aman, Johannes Frank, Jing Liao, Huachun Zou, Ninie Y. Wang, Jing Wu, Xiaoting Liu, Tao Li, Yuan Fang, Zhangming Niu, Guang Yang, Jiangshui Hong, Qian Wang, Guobing Chen, Jun Li, Hou-Zao Chen, Lin Kang, Huanxing Su, Brian C. Gilmour, Xinqiang Zhu, Hong Jiang, Na He, Jun Tao, Sean Xiao Leng, Tanjun Tong, Jean Woo*, 2020
- Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage., Emma Bolderson*, Joshua T Burgess, Jun Li, Neha S Gandhi, Didier Boucher, Laura V Croft, Samuel Beard, Jennifer J Plowman, Amila Suraweera, Mark N Adams, Ali Naqi, Shu-Dong Zhang, David A Sinclair, Kenneth J O'Byrne, Derek J Richard*, 2019
- A conserved NAD+ binding pocket that regulates protein-protein interactions during aging., Jun Li, Michael S. Bonkowski, Sébastien Moniot, Dapeng Zhang, Basil P. Hubbard, Alvin J.Y. Ling, Luis A. Rajman, Bo Qin, Zhenkun Lou, Vera Gorbunova, L. Aravind, Clemens Steegborn and David A. Sinclair*, 2017
- NAD+ replenishment significantly improves outcomes in Ataxia telangiectasia models via mitophagy and DNA repair., Evandro Fei Fang, Henok Kassahun, Deborah L. Croteau, Morten Scheibye-Knudsen, Huiming Lu, Raghavendra A. Shamanna, Sumana Kalyanasundaram, Ravi Chand Bollineni, Mark A. Wilson, Wendy B. Iser, Bradley N. Wollman, Marya Morevati, Jun Li, Jesse S. Kerr, Qiping Lu, Tyler B. Waltz, Jane Tian, David A. Sinclair, Mark P. Mattson, Hilde Nilsen, Vilhelm A. Bohr*, 2016
- Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism., Hubbard BP, Loh C, Gomes AP, Li J, Lu Q, Doyle TL, Disch JS, Armour SM, Ellis JL, Vlasuk GP, Sinclair DA*, 2013
- Evidence for a common mechanism of Sirt1 activation by small molecules., Hubbard, P., Gomes, A., Dai, H., Li, J., Case, A., Considine, T., Riera, T., Lee, J., Yen, ES, Lamming, D., Pentelute, B., Schuman, E., Stevens, L., Ling, A., Armour, S., Michan, S., Zhao, H., Jiang, Y., Sweitzer, S., Blum, C., Disch, J., Ng, PY., Howitz, K., Hamaro, Y., Moss, J., Perni, R., Ellis, J., Vlasuk, G. and Sinclair, D.A*, 2013
- Regulation of Phenylalanine Hydroxylase: Conformational changes upon phosphorylation detected by H/D exchange and mass spectrometry., Jun Li and Paul Fitzpatrick*, 2013
- Direct evidence for a phenylalanine site in the regulatory domain of phenylalanine hydroxylase., Jun Li, Udayar Ilangovan, Susan Daubner, Andy Hinck, Paul Fitzpatrick*, 2011
- Regulation of phenylalanine Hydroxylase: Conformational changes upon phenylalanine binding detected by H/D exchange and mass spectrometry., Jun Li, Larry Dangott, and Paul Fitzpatrick*, 2010
- Characterization of metal ligand mutants of phenylalanine hydroxylase: Insights into the plasticity of a 2-histidine-1-carboxylate triad., Jun Li and Paul Fitzpatrick*, 2008
Awards
- 2018: Selected for the 'Outstanding Young Talent' program by the Chinese Academy of Medical Sciences
