Areas of Focus
- Structural biology and molecular cellular mechanisms of aging and degenerative diseases
- Epigenetic regulation of mitochondrial genome and degenerative diseases
- Membrane-less organelles, biomolecular condensates, and phase separation in cells
Work Experience
- 1965-1970: Intern Researcher at Ministry of Health, Institute of Traditional Chinese Medicine
- 1970-present: University of Science and Technology of China, roles from Assistant to Professor
- 1998-2002: Dean of the School of Life Sciences, University of Science and Technology of China
- 2002-2012: Chair of the Teaching Steering Committee for Biology and Bioengineering, Ministry of Education
Academic Background & Achievements
- 1960-1965: Studied at University of Science and Technology of China, graduated in Biophysics
- 1997: Elected as Academician of the Chinese Academy of Sciences
- 2009: Elected as Academician of the Academy of Sciences for the Developing World
Publications
- Structural insights into the specific recognition of mitochondrial ribosome-binding factor hsRBFA and 12 S rRNA by methyltransferase METTL15, MQ Lv, WW Zhou, YJ Hao, FD Li, HF Zhang H, XB Yao, YY Shi*, L Zhang*, 2024
- Phase separation of hnRNPA1 and TERRA regulates telomeric stability, ZY Xu, YR Liu Y, FD Li, Y Yang, H Zhang, X Liu, X Xie, XJ Chen, YY Shi*, L Zhang*, 2024
- Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function, X.D. Liu, S.Q. Shen, P.Z. Wu. F.D. Li, X. Liu, C. Y. Wang, Q.G. Gong, J.H. Wu, X.B. Yao, H. F Zhang,* and Y. Y. Shi*, 2019
- Application of NMR Spectroscopy to Determine Small RNA Structure, P.Z. Wu, X. Liu, G.G. Gong, Y.Y. Shi, J.H. Wu, 2020
- A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing, G.D. Xie, TV. Vo, G. Thillainadesan, S. Holla, B. Zhang, Y. Jiang, M.Q. Lv, Z. Xu, C.Y. Wang, V. Balachandran, Y.Y. Shi Y, F.D Li*, S. Grewal*, 2019
- TRIM66 Reads Unmodified H3R2K4 and H3K56ac to Respond to DNA Damage in Embryonic Stem Cells, J.J. Chen, Z. Wang, X. Guo, F.D. Li, Q.T. Wei, X. Chen, D.S. Gong , Y. Xu, W. Chen, Y. Liu, J. H. Kang*, Y.Y. Shi*, 2019
- Structural Insights Into ceNAP1 Chaperoning Activity Toward ceH2A-H2B, Y. Liu, L.Xu, C. Xie, J. Hong, FD Li, K. Ruan K, JJ. Chen, JH Wu*, YY Shi*, 2019
Awards
- 1994: Awarded 'Outstanding Young and Middle-aged Expert with Outstanding Contributions' by the Chinese Academy of Sciences
- 2007: Awarded the Third National Higher Education Teaching Master Award by the Ministry of Education
- 2021: Awarded the Bei Shizhang Outstanding Contribution Award by the Chinese Biophysical Society
