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Yunyu Shi
Life Science
University of Science and Technology of China
Anhui
Language: Chinese, English
Aging
Degenerative Diseases
Structural Biology
Molecular Mechanisms
Epigenetic Regulation
Mitochondrial Genome
Neurodegenerative Diseases
Biophysics
Biochemistry
Cell Biology
Areas of Focus
- Structural biology and molecular cellular mechanisms of aging and degenerative diseases
- Epigenetic regulation of mitochondrial genome and degenerative diseases
- Membrane-less organelles, biomolecular condensates, biological phase separation and phase transition mechanisms
Work Experience
- 1965-1970: Intern Researcher at the Ministry of Health's Institute of Traditional Chinese Medicine
- 1970-present: Assistant, Lecturer, Associate Professor, Professor at University of Science and Technology of China
- 1998-2002: First Dean of the School of Life Sciences, University of Science and Technology of China
- 2002-2012: Chairman of the Teaching Steering Committee for Biology and Bioengineering, Ministry of Education
Academic Background & Achievements
- 1960-1965: Studied at University of Science and Technology of China, graduated in Biophysics
- 1997: Elected as Academician of the Chinese Academy of Sciences
- 2009: Elected as Academician of the Academy of Sciences for the Developing World
Publications
- Structural insights into the specific recognition of mitochondrial ribosome-binding factor hsRBFA and 12 S rRNA by methyltransferase METTL15, MQ Lv, WW Zhou, YJ Hao, FD Li, HF Zhang H, XB Yao, YY Shi*, L Zhang*, 2024
- Phase separation of hnRNPA1 and TERRA regulates telomeric stability, ZY Xu, YR Liu Y, FD Li, Y Yang, H Zhang, X Liu, X Xie, XJ Chen, YY Shi*, L Zhang*, 2024
- Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function, X.D. Liu, S.Q. Shen, P.Z. Wu. F.D. Li, X. Liu, C. Y. Wang, Q.G. Gong, J.H. Wu, X.B. Yao, H. F Zhang,* and Y. Y. Shi*, 2019
- Application of NMR Spectroscopy to Determine Small RNA Structure, P.Z. Wu, X. Liu, G.G. Gong, Y.Y. Shi, J.H. Wu, 2020
- A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing, G.D. Xie, TV. Vo, G. Thillainadesan, S. Holla, B. Zhang, Y. Jiang, M.Q. Lv, Z. Xu, C.Y. Wang, V. Balachandran, Y.Y. Shi Y, F.D Li*, S. Grewal*, 2019
- TRIM66 Reads Unmodified H3R2K4 and H3K56ac to Respond to DNA Damage in Embryonic Stem Cells, J.J. Chen, Z. Wang, X. Guo, F.D. Li, Q.T. Wei, X. Chen, D.S. Gong , Y. Xu, W. Chen, Y. Liu, J. H. Kang*, Y.Y. Shi*, 2019
- Structural Insights Into ceNAP1 Chaperoning Activity Toward ceH2A-H2B, Y. Liu, L.Xu, C. Xie, J. Hong, FD Li, K. Ruan K, JJ. Chen, JH Wu*, YY Shi*, 2019
Awards
- 1994: Award for Outstanding Young and Middle-aged Experts with Contributions by the Chinese Academy of Sciences
- 2007: Third National Teaching Master Award by the Ministry of Education
- 2021: Bei Shizhang Outstanding Contribution Award by the Biophysical Society of China
