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Wang Chao
Life Science
University of Science and Technology of China
Anhui
Language: Chinese, English
Neuronal Cell Polarity
Chemical Intervention
Scaffold Proteins
Protein Complexes
Structural Biology
Chemical Biology
Molecular Mechanisms
Neural Network Regulation
Disease Pathogenesis
Drug Development
Areas of Focus
- Neuronal cell polarity maintenance and chemical intervention
Work Experience
- 2014/07-2016/02 Postdoctoral Researcher: Hong Kong University of Science and Technology
- 2016/03-Present Researcher/Professor: University of Science and Technology of China, School of Life Sciences
Academic Background & Achievements
- 2005/09-2009/06 Bachelor: Shanghai Jiao Tong University, Bioengineering
- 2009/08-2014/06 PhD: Hong Kong University of Science and Technology, Biochemistry
- 2013/04-2013/07 Visiting Scholar: Duke University School of Medicine
- National Science Foundation 'Outstanding Youth Science Fund' recipient (2021)
- Chinese Academy of Sciences 'Pioneer Initiative' participant (2016)
Publications
- Dynamic interactions between E-cadherin and Ankyrin-G mediate epithelial cell polarity maintenance., Kong C, Qu X, Liu M, Xu W, Chen D, Zhang Y, Zhang S, Zhu F, Liu Z, Li J, Huang C*, and Wang C*., 2023
- Crystal structure of Ankyrin-G in complex with a fragment of Neurofascin reveals binding mechanisms required for integrity of the axon initial segment., He L, Jiang W, Li J*, and Wang C*., 2022
- Promotion of row 1–specific tip complex condensates by Gpsm2-Gαi provides insights into row identity of the tallest stereocilia., Shi Y#, Lin L#, Wang C*, and Zhu J*., 2022
- 5-IP7 is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis., Zhang X#, Li N#, Zhang J#, Zhang Y#, Yang X#, Luo Y, Zhang B, Xu Z, Zhu Z, Yang X, Yan Y, Lin B, Wang S, Chen D, Ye C, Ding Y, Lou M, Wu Q, Hou Z, Zhang K, Liang Z, Wei A, Wang B, Wang C, Jiang N, Zhang W, Xiao G, Ma C, Ren Y, Qi X, Han W, Wang C*, and Rao F*., 2021
- Structural basis of GABARAP-mediated GABAA receptor trafficking and functions on GABAergic synaptic transmission., Ye J#, Zou G#, Zhu R, Kong C, Miao C, Zhang M, Li J*, Xiong W*, and Wang C*., 2021
- Double inhibition and activation mechanisms of Ephexin family RhoGEFs., Zhang M#, Lin L#, Wang C*, and Zhu J*., 2021
- Mechanistic insights into the interactions of dynein regulator Ndel1 with neuronal ankyrins and implications in polarity maintenance., Ye J#, Li J#, Ye F, Zhang Y, Zhang M, and Wang C*., 2020
- Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins., Li J#, Zhu R#, Chen K, Zheng H, Zhao H, Yuan C, Zhang H*, Wang C*, and Zhang M*., 2018
Awards
- USTC 'Academic Leading Talent Training Program' (2021)
- USTC 'Zhai Guanglong Scholar Fund' (2021)
- Life Sciences and Medicine Division Academic Career Development Award (2020)
- Ministry of Education Key Laboratory of Cell Dynamics Outstanding Research Award (2020)
