Professor | Shan Tang | Asia Growth Partners

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Name	Shan Tang
Contact Information	stang@ustc.edu.cn
Language ability	Chinese, English
Province	Anhui

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Name

Shan Tang

Contact Information

stang@ustc.edu.cn

Language ability

Chinese, English

Province

Anhui

University/Lab Affiliation and Title	University of Science and Technology of China
Faculty	Life Sciences
Academic Background & Achievements	2007-2011 Bachelor: Tsinghua University, Department of Chemistry 2011-2016 PhD: Tsinghua University, Department of Chemistry, Supervisor: Lei Liu Awarded 2022 National Youth High-Level Overseas Talent Program
Work Experience	2016-2022 - MRC-Laboratory of Molecular Biology, UK - Postdoctoral Research 2022-present - University of Science and Technology of China, Division of Life Sciences and Medicine - Specially Appointed Professor
Awards	EMBO Long-Term Fellowship (2017-2018) Postdoctoral Research Associate at Queen's College, Cambridge (2018-2020)

University/Lab Affiliation and Title

University of Science and Technology of China

Faculty

Life Sciences

Academic Background & Achievements

2007-2011 Bachelor: Tsinghua University, Department of Chemistry
2011-2016 PhD: Tsinghua University, Department of Chemistry, Supervisor: Lei Liu
Awarded 2022 National Youth High-Level Overseas Talent Program

Work Experience

2016-2022 - MRC-Laboratory of Molecular Biology, UK - Postdoctoral Research
2022-present - University of Science and Technology of China, Division of Life Sciences and Medicine - Specially Appointed Professor

Awards

EMBO Long-Term Fellowship (2017-2018)
Postdoctoral Research Associate at Queen's College, Cambridge (2018-2020)

Areas of Focus	Development of functionalized cell and protein probes for biomedical applications
Publications	Enhanced native chemical ligation by peptide conjugation in trifluoroacetic acid, Dong-Liang Huang, Wu-Chen Guo, Wei-Wei Shi, Yun-Pu Gao, Yong-Kang Zhou, Long-Jie Wang, Chen Wang, Shan Tang, Lei Liu, Ji-Shen Zheng, 2024 Capturing acyl-enzyme intermediates with genetically encoded 2,3-diaminoproionic acid for hydrolase substrate identification, Juan Luo, Yao Yu, Ke Wang, Sizhe He, Longjie Wang, Fangfang Liang, Jason W. Chin, Shan Tang, 2024 Chemical synthesis of a 28kDa full-length PET degrading enzyme ICCG by the removable backbone modification strategy, Yun-Pu Gao, Peng-Fei Sun, Wu-Chen Guo, Yong-Kang Zhou, Ji-Shen Zheng, Shan Tang, 2024 An enzyme-cleavable solubilizing-tag facilitates the chemical synthesis of mirror-image proteins, Yupeng Zheng, Baochang Zhang, Wei-Wei Shi, Xiangyu Deng, Tong-Yue Wang, Dongyang Han, Yuxiang Ren, Ziyi Yang, Yong-Kang Zhou, Jian Kuang, Zhi-Wen Wang, Shan Tang, Ji-Shen Zheng, 2024 L-Glycodisase-cleavable natural glycans facilitate the chemical synthesis of correctly folded disulfide-bonded D-proteins, Weiwei Shi, Tongyue Wang, Ziyi Yang, Yuxiang Ren, Dongyang Han, Yupeng Zheng, Xiangyu Deng, Shan Tang, Ji-Shen Zheng, 2024 Backbone-installed split Intein-assisted ligation for the chemical synthesis of mirror-image proteins, Baochang Zhang, Yupeng Zheng, Guochao Chu, Xiangyu Deng, Tongyue Wang, Weiwei Shi, Yongkang Zhou, Shan Tang, Ji-Shen Zheng, Lei Liu, 2023 Capturing covalent catalytic intermediates by enzyme mutants: recent advances in methodologies and applications, Yongchao Wang, Shan Tang, 2023 Mechanism-based traps enable protease and hydrolase substrate discovery, S. Tang, A.T. Beattie, L. Kafkova, G. Petris, N. Huguenin-Dezot, M. Fiedler, M. Freeman, J.W. Chin, 2022 Rapid Discovery and Evolution of Orthogonal Aminoacyl-tRNA Synthetase-tRNA Pairs, D. Cervettini, S. Tang, S.D. Fried, J.C.W. Willis, L.F.H. Funke, L.J. Colwell, J.W. Chin, 2020 Practical Chemical Synthesis of Atypical Ubiquitin Chains by Using an Isopeptide-Linked Ub Isomer, S. Tang, L.-J. Liang, Y.-Y. Si, S. Gao, J.-X. Wang, J. Liang, Z.-Q. Mei, J.-S. Zheng, L. Liu, 2017 Chemical Synthesis of Membrane Proteins by the Removable Backbone Modification Method, S. Tang, C. Zuo, D.-L. Huang, X.-Y. Cai, L.-H. Zhang, C.-L. Tian, J.-S. Zheng, L. Liu, 2017 Removable Backbone Modification Method for the Chemical Synthesis of Membrane Proteins, J.-B. Li, S. Tang, J.-S. Zheng, C.-L. Tian, L. Liu, 2017 Total Chemical Synthesis of Photoactivatable Proteins for Light-controlled Manipulation of Antigen–antibody Interactions, S. Tang, Z. Wan, Y. Gao, J.-S. Zheng, J. Wang, Y.-Y. Si, X. Chen, H. Qi, L. Liu, W. Liu, 2016 Utilization of a Photoactivatable Antigen System to Illuminate the B Cell Fingering Termination and B Cell Receptor Sorting Mechanisms in the Initiation of B Cell Activation, J. Wang, S. Tang, Z. Wan, Y. Gao, Y. Cao, J. Yi, Y.-Y. Si, H. Zhang, L. Liu, W. Liu, 2016 An Efficient One-Pot Four-Segment Condensation Method for Protein Chemical Synthesis, S. Tang, Y.-Y. Si, Z.-P. Wang, K.-R. Mei, X. Chen, J.-Y. Cheng, J.-S. Zheng, L. Liu, 2015 Chemical Synthesis of a Two-photon-activatable Chemokine and Photon-guided Lymphocyte Migration in Vivo, X. Chen, S. Tang, J.-S. Zheng, R. Zhao, Z.-P. Wang, W. Shao, H.-N. Chang, J.-Y. Cheng, H. Zhao, L. Liu, H. Qi, 2015

Areas of Focus

Development of functionalized cell and protein probes for biomedical applications

Publications

Enhanced native chemical ligation by peptide conjugation in trifluoroacetic acid, Dong-Liang Huang, Wu-Chen Guo, Wei-Wei Shi, Yun-Pu Gao, Yong-Kang Zhou, Long-Jie Wang, Chen Wang, Shan Tang, Lei Liu, Ji-Shen Zheng, 2024
Capturing acyl-enzyme intermediates with genetically encoded 2,3-diaminoproionic acid for hydrolase substrate identification, Juan Luo, Yao Yu, Ke Wang, Sizhe He, Longjie Wang, Fangfang Liang, Jason W. Chin, Shan Tang, 2024
Chemical synthesis of a 28kDa full-length PET degrading enzyme ICCG by the removable backbone modification strategy, Yun-Pu Gao, Peng-Fei Sun, Wu-Chen Guo, Yong-Kang Zhou, Ji-Shen Zheng, Shan Tang, 2024
An enzyme-cleavable solubilizing-tag facilitates the chemical synthesis of mirror-image proteins, Yupeng Zheng, Baochang Zhang, Wei-Wei Shi, Xiangyu Deng, Tong-Yue Wang, Dongyang Han, Yuxiang Ren, Ziyi Yang, Yong-Kang Zhou, Jian Kuang, Zhi-Wen Wang, Shan Tang, Ji-Shen Zheng, 2024
L-Glycodisase-cleavable natural glycans facilitate the chemical synthesis of correctly folded disulfide-bonded D-proteins, Weiwei Shi, Tongyue Wang, Ziyi Yang, Yuxiang Ren, Dongyang Han, Yupeng Zheng, Xiangyu Deng, Shan Tang, Ji-Shen Zheng, 2024
Backbone-installed split Intein-assisted ligation for the chemical synthesis of mirror-image proteins, Baochang Zhang, Yupeng Zheng, Guochao Chu, Xiangyu Deng, Tongyue Wang, Weiwei Shi, Yongkang Zhou, Shan Tang, Ji-Shen Zheng, Lei Liu, 2023
Capturing covalent catalytic intermediates by enzyme mutants: recent advances in methodologies and applications, Yongchao Wang, Shan Tang, 2023
Mechanism-based traps enable protease and hydrolase substrate discovery, S. Tang, A.T. Beattie, L. Kafkova, G. Petris, N. Huguenin-Dezot, M. Fiedler, M. Freeman, J.W. Chin, 2022
Rapid Discovery and Evolution of Orthogonal Aminoacyl-tRNA Synthetase-tRNA Pairs, D. Cervettini, S. Tang, S.D. Fried, J.C.W. Willis, L.F.H. Funke, L.J. Colwell, J.W. Chin, 2020
Practical Chemical Synthesis of Atypical Ubiquitin Chains by Using an Isopeptide-Linked Ub Isomer, S. Tang, L.-J. Liang, Y.-Y. Si, S. Gao, J.-X. Wang, J. Liang, Z.-Q. Mei, J.-S. Zheng, L. Liu, 2017
Chemical Synthesis of Membrane Proteins by the Removable Backbone Modification Method, S. Tang, C. Zuo, D.-L. Huang, X.-Y. Cai, L.-H. Zhang, C.-L. Tian, J.-S. Zheng, L. Liu, 2017
Removable Backbone Modification Method for the Chemical Synthesis of Membrane Proteins, J.-B. Li, S. Tang, J.-S. Zheng, C.-L. Tian, L. Liu, 2017
Total Chemical Synthesis of Photoactivatable Proteins for Light-controlled Manipulation of Antigen–antibody Interactions, S. Tang, Z. Wan, Y. Gao, J.-S. Zheng, J. Wang, Y.-Y. Si, X. Chen, H. Qi, L. Liu, W. Liu, 2016
Utilization of a Photoactivatable Antigen System to Illuminate the B Cell Fingering Termination and B Cell Receptor Sorting Mechanisms in the Initiation of B Cell Activation, J. Wang, S. Tang, Z. Wan, Y. Gao, Y. Cao, J. Yi, Y.-Y. Si, H. Zhang, L. Liu, W. Liu, 2016
An Efficient One-Pot Four-Segment Condensation Method for Protein Chemical Synthesis, S. Tang, Y.-Y. Si, Z.-P. Wang, K.-R. Mei, X. Chen, J.-Y. Cheng, J.-S. Zheng, L. Liu, 2015
Chemical Synthesis of a Two-photon-activatable Chemokine and Photon-guided Lymphocyte Migration in Vivo, X. Chen, S. Tang, J.-S. Zheng, R. Zhao, Z.-P. Wang, W. Shao, H.-N. Chang, J.-Y. Cheng, H. Zhao, L. Liu, H. Qi, 2015

Functionalized Cells Protein Probes Biomedical Applications Genetic Code Expansion Bioorthogonal Chemistry Enzyme Activity Post-Translational Modifications Cancer Therapy Pathogen Targeting Synthetic Biology

Ruilian Yao - Shanghai Jiao Tong University

Changbei Ma - Central South University

Yangyang Shao - Zhejiang University

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