Professor | Xu Chao | Asia Growth Partners

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Name	Xu Chao
Contact Information	xuchaor@ustc.edu.cn
Language ability	English, Chinese
Province	Anhui

Upload Avatar (500 x 500)

Name

Xu Chao

Contact Information

xuchaor@ustc.edu.cn

Language ability

English, Chinese

Province

Anhui

University/Lab Affiliation and Title	University of Science and Technology of China
Faculty	Life Sciences
Academic Background & Achievements	2000 - Bachelor's degree: University of Science and Technology of China 2005 - Doctorate: University of Science and Technology of China Published over 80 SCI research papers with more than 4600 citations
Work Experience	2006-2008 - Postdoctoral Researcher at Mayo Clinic, USA 2009-2015 - Researcher at University of Toronto, Structural Genomics Consortium

University/Lab Affiliation and Title

University of Science and Technology of China

Faculty

Life Sciences

Academic Background & Achievements

2000 - Bachelor's degree: University of Science and Technology of China
2005 - Doctorate: University of Science and Technology of China
Published over 80 SCI research papers with more than 4600 citations

Work Experience

2006-2008 - Postdoctoral Researcher at Mayo Clinic, USA
2009-2015 - Researcher at University of Toronto, Structural Genomics Consortium

Areas of Focus	Structural biology and chemical biology techniques Molecular mechanisms of chemical modifications in eukaryotic macromolecules Pathogenic mechanisms of abnormal modifications (tumors and neurodegenerative diseases) Drug design through chemical small molecule screening
Publications	Mechanism of Ψ-Pro/C-degron recognition by the CRL2FEM1B ubiquitin ligase, Chen X., Raiff A., Li S., Guo Q., Zhang J., Zhou H., Timms R.T., Yao X., Elledge S.J., Koren I., Zhang K, Xu C., 2024 Molecular basis for C-degron recognition by CRL2APPBP2 ubiquitin ligase, Zhao S., Olmayev-Yaakobov D., Ru W., Li S., Chen X., Zhang J., Yao X., Koren I., Zhang K., Xu C., 2023 Molecular basis for METTL9-mediated N1-histidine methylation, Wang X., Xie H., Guo Q., Cao D., Ru W., Zhao S., Zhu Z., Zhang J., Pan W., Yao X., Xu C., 2023 Molecular basis for Eaf3-mediated assembly of Rpd3S and NuA4, Chen Z., Lundy T., Zhu Z., Hoskins V.E., Zhang J., Yao X., Strahl B.D., Xu C., 2023 TRIM-away via Gln/C-degrons, Guo Q., Chen X., Xu C., 2022 Structural basis for Gemin5 decamer-mediated mRNA binding, Guo Q., Zhao S., Francisco-Velilla R., Zhang J., Embarc-Buh A., Abellan S., Lv M., Tang P., Gong Q., Shen H., Sun L., Yao X., Min J., Shi Y., Martínez-Salas E., Zhang K., Xu C., 2022 Molecular basis for PICS-mediated piRNA biogenesis and cell division, Wang X., Zeng C., Liao S., Zhu Z., Zhang J., Tu X., Yao X., Feng X., Guang S., Xu C., 2021 Molecular basis for arginine C-terminal degron recognition by Cul2FEM1 E3 ligase, Chen X., Liao X., Makaros Y, Guo Q., Zhu Z., Krizelman R., Dahan K., Tu X., Yao X., Koren I., Xu C., 2021 Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis, Liao S., Rajendraprasad G., Wang N., Eibes S., Gao J., Yu H., Wu G., Tu X., Huang H., Barisic M. Xu C., 2019 Functional proteomics identified a PICS complex required for piRNA maturation and chromosome segregation, Zeng C., Weng C., Wang X., Yan Y., Li W., Xu D., Hong M., Liao S., Dong M., Feng X., Xu C., Guang S., 2019 Structural insights into SETD3-mediated histidine methylation on β-actin, Guo Q., Liao S., Kwiatkowski S., Tomaka W., Yu H., Wu G., Tu X., Min J., Drozak J., Xu C., 2019 Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly, Xu C., Ishikawa H., Izumikawa K., Li L., He H., Nobe Y., Yamauchi Y., Shahjee M.H., Wu X., Yu Y., Isobe T., Takahashi N., Min J., 2016 Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain, Xu C., Wang X., Liu K., Roundtree I., Tempel W., Li Y., Lu Z., He C., Min J., 2014 RPRD1A and RPRD1B Serve as RNAPolymerase II Carboxyl-Terminal Domain Scaffolds to Recruit RPAP2 for Serine 5 Dephosphorylation, Ni Z., Xu C., Guo X., Hunter G., Kuznetsova O., Tempel W., Marcon E., Zhong G., Guo H., Kuo W., Li J., Young P., Olsen J., Wan C., Loppnau P., Bakkouri M., Senisterra G., He H., Huang H., Sidhu S., Emili A., Murphy S., Mosley A., Arrowsmith C., Min J., Greenblatt J., 2014 Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development, Xu Y., Xu C., Kato A., Tempel W., Abreu J.C., Bian C., Hu Y., Hu D., Zhao B., Cerovina T., Diao J., Wu F., He H.H., Cui Q., Clark E., Ma C., Barbara A., Veenstra G.J.C., Xu G., Kaiser U.B., Liu X.S., Sugrue S.P., He X., Min J., Kato Y., Shi Y.G., 2012 Sequence-specific Recognition of a PxLPxI/L Motif by the Ankyrin-repeat Tumbler Lock, Xu C., Jin J., Bian C., Lam R., Tian R., Weist R., You L., Nie J., Bochkarev A., Tempel W., Tan C., Wasney G., Vedadi M., Gish G., Arrowsmith C., Pawson T., Yang X., Min J., 2012 Structural Basis of Sgf29 Tandem Tudor Domains Selectively Binding Methylated Histone H3K4 to Regulate Enzymatic Activity of the SAGA Complex, Bian C., Xu C., Ruan J., Lee K., Burke T., Tempel W., Barsyte D., Li J., Wu M., Zhou B., Fleharty B., Paulson A., Allali-Hassani A., Zhou J., Mer G., Grant P., Workman J., Zang J., Min J., 2011 Structural Basis of Selective Binding of Nonmethylated CpG islands by the CXXC Domain of CFP1, Xu C., Bian C., Lam R., Dong A. Min J., 2011 Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2), Xu C., Bian C., Yang W., Galka M., Ouyang H., Chen C., Qiu W., Liu H., Jones A., MacKenzie F., Pan P., Li S., Wang H., Min J., 2010

Areas of Focus

Structural biology and chemical biology techniques
Molecular mechanisms of chemical modifications in eukaryotic macromolecules
Pathogenic mechanisms of abnormal modifications (tumors and neurodegenerative diseases)
Drug design through chemical small molecule screening

Publications

Mechanism of Ψ-Pro/C-degron recognition by the CRL2FEM1B ubiquitin ligase, Chen X., Raiff A., Li S., Guo Q., Zhang J., Zhou H., Timms R.T., Yao X., Elledge S.J., Koren I., Zhang K, Xu C., 2024
Molecular basis for C-degron recognition by CRL2APPBP2 ubiquitin ligase, Zhao S., Olmayev-Yaakobov D., Ru W., Li S., Chen X., Zhang J., Yao X., Koren I., Zhang K., Xu C., 2023
Molecular basis for METTL9-mediated N1-histidine methylation, Wang X., Xie H., Guo Q., Cao D., Ru W., Zhao S., Zhu Z., Zhang J., Pan W., Yao X., Xu C., 2023
Molecular basis for Eaf3-mediated assembly of Rpd3S and NuA4, Chen Z., Lundy T., Zhu Z., Hoskins V.E., Zhang J., Yao X., Strahl B.D., Xu C., 2023
TRIM-away via Gln/C-degrons, Guo Q., Chen X., Xu C., 2022
Structural basis for Gemin5 decamer-mediated mRNA binding, Guo Q., Zhao S., Francisco-Velilla R., Zhang J., Embarc-Buh A., Abellan S., Lv M., Tang P., Gong Q., Shen H., Sun L., Yao X., Min J., Shi Y., Martínez-Salas E., Zhang K., Xu C., 2022
Molecular basis for PICS-mediated piRNA biogenesis and cell division, Wang X., Zeng C., Liao S., Zhu Z., Zhang J., Tu X., Yao X., Feng X., Guang S., Xu C., 2021
Molecular basis for arginine C-terminal degron recognition by Cul2FEM1 E3 ligase, Chen X., Liao X., Makaros Y, Guo Q., Zhu Z., Krizelman R., Dahan K., Tu X., Yao X., Koren I., Xu C., 2021
Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis, Liao S., Rajendraprasad G., Wang N., Eibes S., Gao J., Yu H., Wu G., Tu X., Huang H., Barisic M. Xu C., 2019
Functional proteomics identified a PICS complex required for piRNA maturation and chromosome segregation, Zeng C., Weng C., Wang X., Yan Y., Li W., Xu D., Hong M., Liao S., Dong M., Feng X., Xu C., Guang S., 2019
Structural insights into SETD3-mediated histidine methylation on β-actin, Guo Q., Liao S., Kwiatkowski S., Tomaka W., Yu H., Wu G., Tu X., Min J., Drozak J., Xu C., 2019
Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly, Xu C., Ishikawa H., Izumikawa K., Li L., He H., Nobe Y., Yamauchi Y., Shahjee M.H., Wu X., Yu Y., Isobe T., Takahashi N., Min J., 2016
Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain, Xu C., Wang X., Liu K., Roundtree I., Tempel W., Li Y., Lu Z., He C., Min J., 2014
RPRD1A and RPRD1B Serve as RNAPolymerase II Carboxyl-Terminal Domain Scaffolds to Recruit RPAP2 for Serine 5 Dephosphorylation, Ni Z., Xu C., Guo X., Hunter G., Kuznetsova O., Tempel W., Marcon E., Zhong G., Guo H., Kuo W., Li J., Young P., Olsen J., Wan C., Loppnau P., Bakkouri M., Senisterra G., He H., Huang H., Sidhu S., Emili A., Murphy S., Mosley A., Arrowsmith C., Min J., Greenblatt J., 2014
Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development, Xu Y., Xu C., Kato A., Tempel W., Abreu J.C., Bian C., Hu Y., Hu D., Zhao B., Cerovina T., Diao J., Wu F., He H.H., Cui Q., Clark E., Ma C., Barbara A., Veenstra G.J.C., Xu G., Kaiser U.B., Liu X.S., Sugrue S.P., He X., Min J., Kato Y., Shi Y.G., 2012
Sequence-specific Recognition of a PxLPxI/L Motif by the Ankyrin-repeat Tumbler Lock, Xu C., Jin J., Bian C., Lam R., Tian R., Weist R., You L., Nie J., Bochkarev A., Tempel W., Tan C., Wasney G., Vedadi M., Gish G., Arrowsmith C., Pawson T., Yang X., Min J., 2012
Structural Basis of Sgf29 Tandem Tudor Domains Selectively Binding Methylated Histone H3K4 to Regulate Enzymatic Activity of the SAGA Complex, Bian C., Xu C., Ruan J., Lee K., Burke T., Tempel W., Barsyte D., Li J., Wu M., Zhou B., Fleharty B., Paulson A., Allali-Hassani A., Zhou J., Mer G., Grant P., Workman J., Zang J., Min J., 2011
Structural Basis of Selective Binding of Nonmethylated CpG islands by the CXXC Domain of CFP1, Xu C., Bian C., Lam R., Dong A. Min J., 2011
Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2), Xu C., Bian C., Yang W., Galka M., Ouyang H., Chen C., Qiu W., Liu H., Jones A., MacKenzie F., Pan P., Li S., Wang H., Min J., 2010

Structural Biology Chemical Biology Molecular Mechanisms Eukaryotic Macromolecules Chemical Modifications Pathogenic Mechanisms Tumors Neurodegenerative Diseases Drug Design Small Molecule Screening

Yihua Chen - East China Normal University

Yihua Chen - East China Normal University

Sarah Perrett - University of Chinese Academy of Sciences

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