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Chunlei Cang
ccang@ustc.edu.cn
English, Chinese
Anhui
University of Science and Technology of China
Basic Medical Sciences
  • 1999-2003 Bachelor of Science: Fudan University
  • 2003-2009 Ph.D. in Neurobiology: Fudan University
  • 2009-2014 Postdoctoral Research: University of Pennsylvania
  • Discovery of a novel potassium ion channel KEL
  • Discovery of an ATP-sensitive sodium ion channel complex composed of TPC and mTORC1
  • Discovery of a voltage-gated sodium ion channel with a 2x6 transmembrane structure
  • 2009-2014 - University of Pennsylvania - Postdoctoral Researcher
  • 2014-2015 - University of Pennsylvania - Assistant Researcher
  • 2015-present - University of Science and Technology of China - Professor
Characteristics, functions, and modulation of lysosomal membrane ion channels
Role of lysosomal and other organelle ion channels in intracellular signal transduction
Mechanism research of organelle ion channel-related diseases and development of new drugs targeting organelle ion channels
  • TMEM175 is an Organelle K(+) Channel Regulating Lysosomal Function, Cang, C., Aranda, K., Seo, YJ., Gasnier, B., Ren, D., 2015
  • mTOR Regulates Lysosomal ATP-sensitive Two-Pore Na+ Channels to Adapt to Metabolic State, Cang, C., Zhou, Y., Navarro, B., Aranda, K., Shi, L., Battaglia-Hsu, S., Nissim, I., Clapham, D. and Ren, D., 2013
  • A non-inactivating high-voltage-activated two-pore Na+ channel that supports ultra-long action potentials and membrane bistability, Cang, C.*, Aranda, K., Ren, D.*, 2014
  • The voltage-gated sodium channel TPC1 confers endolysosomal excitability, Cang, C.*, Bekele, B., Ren, D.*, 2014
  • PKCepsilon-dependent potentiation of TTX-resistant Nav1.8 current by neurokinin-1 receptor activation in rat dorsal root ganglion neurons, Cang CL, Zhang H, Zhang YQ, Zhao ZQ, 2009
  • Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCe: a novel pathway for heat hyperalgesia, Zhang H., Cang CL, Kawasaki Y, Liang LL, Zhang YQ, Ji RR, Zhao ZQ, 2007
  • Thermal nociception in adult Drosophila: behavioral characterization and the role of the painless gene, Xu SY, Cang CL, Liu XF, Peng YQ, Ye YZ, Zhao ZQ, Guo AK, 2006
Lysosomal Membrane Ion Channels Modulation Signal Transduction Organelle Disease Mechanism Drug Development Potassium Channel Sodium Channel Membrane Potential

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