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Chunlei Cang
Basic Medical Sciences
University of Science and Technology of China
Anhui
Language: English, Chinese
Lysosomal Membrane
Ion Channels
Modulation
Signal Transduction
Organelle
Disease Mechanism
Drug Development
Potassium Channel
Sodium Channel
Membrane Potential
Areas of Focus
- Characteristics, functions, and modulation of lysosomal membrane ion channels
- Role of lysosomal and other organelle ion channels in intracellular signal transduction
- Mechanism research of organelle ion channel-related diseases and development of new drugs targeting organelle ion channels
Work Experience
- 2009-2014 - University of Pennsylvania - Postdoctoral Researcher
- 2014-2015 - University of Pennsylvania - Assistant Researcher
- 2015-present - University of Science and Technology of China - Professor
Academic Background & Achievements
- 1999-2003 Bachelor of Science: Fudan University
- 2003-2009 Ph.D. in Neurobiology: Fudan University
- 2009-2014 Postdoctoral Research: University of Pennsylvania
- Discovery of a novel potassium ion channel KEL
- Discovery of an ATP-sensitive sodium ion channel complex composed of TPC and mTORC1
- Discovery of a voltage-gated sodium ion channel with a 2x6 transmembrane structure
Publications
- TMEM175 is an Organelle K(+) Channel Regulating Lysosomal Function, Cang, C., Aranda, K., Seo, YJ., Gasnier, B., Ren, D., 2015
- mTOR Regulates Lysosomal ATP-sensitive Two-Pore Na+ Channels to Adapt to Metabolic State, Cang, C., Zhou, Y., Navarro, B., Aranda, K., Shi, L., Battaglia-Hsu, S., Nissim, I., Clapham, D. and Ren, D., 2013
- A non-inactivating high-voltage-activated two-pore Na+ channel that supports ultra-long action potentials and membrane bistability, Cang, C.*, Aranda, K., Ren, D.*, 2014
- The voltage-gated sodium channel TPC1 confers endolysosomal excitability, Cang, C.*, Bekele, B., Ren, D.*, 2014
- PKCepsilon-dependent potentiation of TTX-resistant Nav1.8 current by neurokinin-1 receptor activation in rat dorsal root ganglion neurons, Cang CL, Zhang H, Zhang YQ, Zhao ZQ, 2009
- Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCe: a novel pathway for heat hyperalgesia, Zhang H., Cang CL, Kawasaki Y, Liang LL, Zhang YQ, Ji RR, Zhao ZQ, 2007
- Thermal nociception in adult Drosophila: behavioral characterization and the role of the painless gene, Xu SY, Cang CL, Liu XF, Peng YQ, Ye YZ, Zhao ZQ, Guo AK, 2006
