Professor | Cheng Sun | Asia Growth Partners

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Name	Cheng Sun
Contact Information	charless@ustc.edu.cn
Language ability	English, Chinese
Province	Anhui

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Name

Cheng Sun

Contact Information

charless@ustc.edu.cn

Language ability

English, Chinese

Province

Anhui

University/Lab Affiliation and Title	University of Science and Technology of China
Faculty	Basic Medical Sciences
Academic Background & Achievements	2012 - PhD in Life Sciences: University of Science and Technology of China Recipient of the Chinese Academy of Sciences President's Award 2014 - Young Scholar Award from the Chinese Society of Immunology 2015 - International Young Scholar Award from the Society for Immunotherapy of Cancer, USA 2020 - Supported by the Anhui Provincial Outstanding Youth Fund Supported by the National Natural Science Foundation of China Excellent Youth Fund
Awards	Chinese Academy of Sciences President's Award Young Scholar Award from the Chinese Society of Immunology (2014) International Young Scholar Award from the Society for Immunotherapy of Cancer, USA (2015) Anhui Provincial Outstanding Youth Fund (2020) National Natural Science Foundation of China Excellent Youth Fund

University/Lab Affiliation and Title

University of Science and Technology of China

Faculty

Basic Medical Sciences

Academic Background & Achievements

2012 - PhD in Life Sciences: University of Science and Technology of China
Recipient of the Chinese Academy of Sciences President's Award
2014 - Young Scholar Award from the Chinese Society of Immunology
2015 - International Young Scholar Award from the Society for Immunotherapy of Cancer, USA
2020 - Supported by the Anhui Provincial Outstanding Youth Fund
Supported by the National Natural Science Foundation of China Excellent Youth Fund

Awards

Chinese Academy of Sciences President's Award
Young Scholar Award from the Chinese Society of Immunology (2014)
International Young Scholar Award from the Society for Immunotherapy of Cancer, USA (2015)
Anhui Provincial Outstanding Youth Fund (2020)
National Natural Science Foundation of China Excellent Youth Fund

Areas of Focus	Human liver NK cell immune properties and functional regulation Bioinformatics analysis of liver spatiotemporal heterogeneity Discovery and validation of human NK cell immunotherapy targets
Publications	Human CD96 correlates to NK cell exhaustion and predicts the prognosis of human hepatocellular carcinoma., Sun H, Huang Q, Huang M, Wen H, Lin R, Zheng M, Qu K, Li K, Wei H, Xiao W, Sun R, Tian Z, Sun C, 2018 Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion., Sun C, Lan P, Han Q, Huang M, Zhang Z, Xu G, Song J, Wang J, Wei H, Zhang J, Sun R, Zhang C, Tian Z, 2018 Accumulation of Tumor-Infiltrating CD49a+ NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma., Sun H, Liu L, Huang Q, Liu H, Huang M, Wang J, Wen H, Lin R, Qu K, Li K, Wei H, Xiao W, Sun R, Tian Z, Sun C, 2019 Reduced CD160 Expression Contributes to Impaired NK-cell Function and Poor Clinical Outcomes in Patients with HCC., Sun H, Xu J, Huang Q, Huang M, Li K, Qu K, Wen H, Lin R, Zheng M, Wei H, Xiao W, Sun R, Tian Z, Sun C, 2018 TGF-β1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence., Sun C, Fu B, Gao Y, Liao X, Sun R, Tian Z, Wei H, 2012 High NKG2A Expression Contributes to NK Cell Exhaustion and Predicts a Poor Prognosis of Patients with Liver Cancer., Sun C, Xu J, Huang Q, Huang M, Wen H, Zhang C, Wang J, Song J, Zheng M, Sun H, Wei H, Xiao W, Sun R, Tian Z, 2017 NK cell receptor imbalance and NK cell dysfunction in HBV infection and hepatocellular carcinoma., Sun C, Sun H, Zhang C, Tian Z, 2015 Natural killer cell dysfunction in hepatocellular carcinoma and NK cell-based immunotherapy., Sun C, Sun HY, Xiao WH, Zhang C, Tian Z, 2015 CD4+ T Cells Play a Critical Role in Microbiota-Maintained Anti-HBV Immunity in a Mouse Model., Wu T, Li F, Chen Y, Wei H, Tian Z, Sun C, Sun R, 2019 The Rise of NK Cell Checkpoints as Promising Therapeutic Targets in Cancer Immunotherapy., Sun H, Sun C, 2019 Association of decreased expression of the macrophage scavenger receptor MARCO with tumor progression and poor prognosis in human hepatocellular carcinoma., Sun H, Song J, Weng C, Xu J, Huang M, Huang Q, Sun R, Xiao W, Sun C, 2017 CD200R, a co-inhibitory receptor on immune cells, predicts the prognosis of human hepatocellular carcinoma., Sun H, Xu J, Huang M, Huang Q, Sun R, Xiao W, Sun C, 2016 Establishment and Preclinical Therapy of Patient-derived Hepatocellular Carcinoma Xenograft Model., Yuwei Wu, Jinyu Wang, Xiaodong Zheng, Yongyan Chen, Mei Huang, Qiang Huang, Weihua Xiao, Haiming Wei, Zhigang Tian, Rui Sun, Sun C, 2020 The predictive value of centre tumour CD8⁺ T cells in patients with hepatocellular carcinoma: comparison with Immunoscore., Sun C, Xu J, Song J, Liu C, Wang J, Weng C, Sun H, Wei H, Xiao W, Sun R, Tian Z, 2015 NK cells in immunotolerant organs., Sun H, Sun C, Tian Z, Xiao W, 2013 Tissue-resident lymphocytes: from adaptive to innate immunity., Sun H, Sun C, Xiao W, Sun R, 2019

Areas of Focus

Human liver NK cell immune properties and functional regulation
Bioinformatics analysis of liver spatiotemporal heterogeneity
Discovery and validation of human NK cell immunotherapy targets

Publications

Human CD96 correlates to NK cell exhaustion and predicts the prognosis of human hepatocellular carcinoma., Sun H, Huang Q, Huang M, Wen H, Lin R, Zheng M, Qu K, Li K, Wei H, Xiao W, Sun R, Tian Z, Sun C, 2018
Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion., Sun C, Lan P, Han Q, Huang M, Zhang Z, Xu G, Song J, Wang J, Wei H, Zhang J, Sun R, Zhang C, Tian Z, 2018
Accumulation of Tumor-Infiltrating CD49a+ NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma., Sun H, Liu L, Huang Q, Liu H, Huang M, Wang J, Wen H, Lin R, Qu K, Li K, Wei H, Xiao W, Sun R, Tian Z, Sun C, 2019
Reduced CD160 Expression Contributes to Impaired NK-cell Function and Poor Clinical Outcomes in Patients with HCC., Sun H, Xu J, Huang Q, Huang M, Li K, Qu K, Wen H, Lin R, Zheng M, Wei H, Xiao W, Sun R, Tian Z, Sun C, 2018
TGF-β1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence., Sun C, Fu B, Gao Y, Liao X, Sun R, Tian Z, Wei H, 2012
High NKG2A Expression Contributes to NK Cell Exhaustion and Predicts a Poor Prognosis of Patients with Liver Cancer., Sun C, Xu J, Huang Q, Huang M, Wen H, Zhang C, Wang J, Song J, Zheng M, Sun H, Wei H, Xiao W, Sun R, Tian Z, 2017
NK cell receptor imbalance and NK cell dysfunction in HBV infection and hepatocellular carcinoma., Sun C, Sun H, Zhang C, Tian Z, 2015
Natural killer cell dysfunction in hepatocellular carcinoma and NK cell-based immunotherapy., Sun C, Sun HY, Xiao WH, Zhang C, Tian Z, 2015
CD4+ T Cells Play a Critical Role in Microbiota-Maintained Anti-HBV Immunity in a Mouse Model., Wu T, Li F, Chen Y, Wei H, Tian Z, Sun C, Sun R, 2019
The Rise of NK Cell Checkpoints as Promising Therapeutic Targets in Cancer Immunotherapy., Sun H, Sun C, 2019
Association of decreased expression of the macrophage scavenger receptor MARCO with tumor progression and poor prognosis in human hepatocellular carcinoma., Sun H, Song J, Weng C, Xu J, Huang M, Huang Q, Sun R, Xiao W, Sun C, 2017
CD200R, a co-inhibitory receptor on immune cells, predicts the prognosis of human hepatocellular carcinoma., Sun H, Xu J, Huang M, Huang Q, Sun R, Xiao W, Sun C, 2016
Establishment and Preclinical Therapy of Patient-derived Hepatocellular Carcinoma Xenograft Model., Yuwei Wu, Jinyu Wang, Xiaodong Zheng, Yongyan Chen, Mei Huang, Qiang Huang, Weihua Xiao, Haiming Wei, Zhigang Tian, Rui Sun, Sun C, 2020
The predictive value of centre tumour CD8⁺ T cells in patients with hepatocellular carcinoma: comparison with Immunoscore., Sun C, Xu J, Song J, Liu C, Wang J, Weng C, Sun H, Wei H, Xiao W, Sun R, Tian Z, 2015
NK cells in immunotolerant organs., Sun H, Sun C, Tian Z, Xiao W, 2013
Tissue-resident lymphocytes: from adaptive to innate immunity., Sun H, Sun C, Xiao W, Sun R, 2019

Nk Cells Liver Immune Properties Functional Regulation Bioinformatics Spatiotemporal Heterogeneity Immunotherapy Target Discovery Validation Human

Xiao Zhang - Nanjing Medical University

Yang Li - Peking University

Rongqing Pan - Zhejiang University

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