2007 - Bachelor's Degree: Minzu University of China
2012 - Doctorate: Peking University
Selected for the National Youth Talent Support Program
2012-09 to 2021-06 - Johns Hopkins University School of Medicine, Sidney Kimmel Comprehensive Cancer Center - Postdoctoral Researcher and Research Associate
2021 - Present - University of Science and Technology of China, School of Life Sciences and Medicine - Established the Tumor Epigenetics Laboratory
2009 - Peking University Corning Doctoral Scholarship
2011 - Peking University Corning Doctoral Scholarship
2012 - Outstanding Graduate of Peking University
2018 - Keystone Symposia Future of Science Fund Scholarship
2019 - National Youth Talent Support Program
Research
Biological functions and molecular mechanisms of epigenetic abnormalities in tumor development Epigenetic changes in cell senescence and tissue aging and their role in tumorigenesis Development of anti-tumor and anti-aging drugs targeting epigenetic molecules
DNA methylation patterns separate senescence from transformation potential and indicate cancer risk, Wenbing Xie, Ioannis Kagiampakis, Lixia Pan, Yang W. Zhang, Lauren Murphy, Xiangqian Kong, Limin Xia, Fillipe LF Carvlho, Subhojit Sen, Ray-Whay Chiu Yen, Cynthia A. Zahnow, Nita Ahuja, Stephen B. Baylin* and Hariharan Easwaran*, 2018
Defining UHRF1 Domains That Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties, Xiangqian Kong#, Jie Chen#, Wenbing Xie#, Stephen M. Brown, Yi Cai, Kaichun Wu, Daiming Fan, Yongzhan Nie, Rochelle L. Tiedemann, Yong Tao, Ray-Whay Chiu Yen, Michael J. Topper, Cynthia A. Zahnow, Hariharan Easwaran, Scott B. Rothbart*, Limin Xia*, Stephen B. Baylin*, 2019
DNA methylation in senescence, aging and cancer, Wenbing Xie, Stephen B. Baylin, Hariharan Easwaran, 2019
The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions, Wenbing Xie#, Te Ling#, Yonggang Zhou#, Weijun Feng, Qiaoyun Zhu, Henk Stunnenberg, Ingrid Grummt and Wei Tao, 2012
NuRD blocks reprogramming of mouse somatic cells into pluripotent stem cells, Min Luo#, Te Ling#, Wenbing Xie#, He Sun#, Yonggang Zhou, Qiaoyun Zhu, Meili Shen, Le Zong, Guoliang Lyu, Yun Zhao, Tao Ye, Jun Gu, Wei Tao, Zhigang Lu and Ingrid Grummt, 2013
CHD4/NuRD maintains demethylation state of rDNA promoters through inhibiting the expression of the rDNA methyltransferase recruiter TIP5, Te Ling#, Wenbing Xie#, Min Luo#, Meili Shen, Qiaoyun Zhu, Le Zong, Tingting Zhou, Jun Gu, Zhigang Lu, Feixiong Zhang and Wei Tao, 2013
Epigenetic therapy inhibits metastases by disrupting premetastatic niches, Zhihao Lu#, Jianling Zou#, Shuang Li#, Michael J. Topper, Yong Tao, Hao Zhang, Xi Jiao, Wenbing Xie, Xiangqian Kong, Michelle Vaz, Huili Li, Yi Cai, Limin Xia, Kristen Rodgers, Beverly Lee, Joanne B. Riemer, Xi Jiao, Ray-Whay Chiu Yen, Chi-Ping Day, Weiqiang Zhang, Ying Cui, Hariharan Easwaran, Alicia Hulbert, KiBem Kim, Shibin Zhou, Stephen C. Yang, Richard J. Battafarano, Errol L. Bush, Stephen R. Broderick, Stephen M. Cattaneo, Julie R. Brahmer, Charles M. Rudin, John Wrangle, Yuping Mei, Young J. Kim, Bin Zhang, Ken Kang-Hsin Wang, Patrick M. Forde, Joseph B. Margolick, Barry D. Nelkin, Cynthia A. Zahnow, Drew M. Pardoll1, Franck Housseau, Stephen B. Baylin*, Lin Shen*, Malcolm V. Brock*, 2020
Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and BrafV600E-Induced Tumorigenesis, Yong Tao#, Byunghak Kang#, Daniel Petkovich, Julie In, Genevieve Stein-O'Brien, Xiangqian Kong, Wenbing Xie, Nicholas Zachos, Shinji Maegawa, Stephen Brown, Ray-Whay Chiu Yen, Jai Thakor, Zhihao Lu, Yuezheng Zhang, Izaskun Mallona Gonzalez, Miguel Angel Peinado, Cynthia A. Zahnow, Nita Ahuja, Elana Fertig, Jean-Pierre Issa, Stephen B. Baylin*, Hariharan Easwaran*, 2019
Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1, Fei Ye#, Xiangqian Kong#, Shijie Chen, Hao Zhang, Yan Liu, Zhiyuan Shao, Jia Jin, Yi Cai, Rukang Zhang, Linjuan Li, Yang W. Zhang, Yu-Chih Liu, Chenhua Zhang, Wenbing Xie, Kunqian Yu, Hong Ding, Kehao Zhao, Hualiang Jiang, Stephen B. Baylin* and Cheng Luo*, 2018
Metastasis-related methyltransferase Merm1 represses the methyltransferase activity of Dnmt3a and facilitates RNA polymerase I transcriptional elongation, Guoliang Lyu#, Le Zong#, Chao Zhang, Xiaoke Huang, Wenbing Xie, Junnan Fang, Yiting Guan, Lijun Zhang, Ting Ni, Jun Gu, Wei Tao, 2018
CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes, Limin Xia#, Wenjie Huang#, Marina Bellani, Michael M. Seidman, Kaichun Wu, Daiming Fan, Yongzhan Nie, Yi Cai, Yang W. Zhang, Lirong Yu, Huili Li, Cynthia A. Zahnow, Wenbing Xie, Ray-Whay Chiu Yen, Feyruz V. Rassool, Stephen B. Baylin, 2017
Acetylation enhances TET2 function in protecting against abnormal DNA methylation during oxidative stress, Yang W. Zhang, Zhihong Wang, Wenbing Xie, Yi Cai, Limin Xia, Hariharan Easwaran, Jianjun Luo, Ray-Whay Chiu Yen, Yana Li, Stephen B. Baylin, 2017
DNA Replication Initiator Cdc6 also Regulates Ribosomal DNA Transcription Initiation, Shijiao Huang, Xiaowei Xu, Guopeng Wang, Guoliang Lu, Wenbing Xie, Wei Tao, Hongyin Zhang, Qing Jiang and Chuanmao Zhang, 2016
Heterochromatin remodeling by CDK12 contributes to learning in Drosophila, Lixia Pan, Wenbing Xie, Kai-Le Li, Zhihao Yang, Jiang Xu, Wenhao Zhang, Lu-Ping Liu, Xingjie Ren, Zhimin He, Junyu Wu, Jin Sun, Hui-Min Wei, Da-Liang Wang, Wei Xie, Wei Li, Jian-Quan Ni*, and Fang-Lin Sun*, 2015
