Professor | Jian Li | Asia Growth Partners

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Name	Jian Li
Contact Information	jianli_204@xmu.edu.cn
Language ability	English, Chinese
Province	Fujian

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Name

Jian Li

Contact Information

jianli_204@xmu.edu.cn

Language ability

English, Chinese

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Life Sciences
Academic Background & Achievements	2005-2011 Ph.D.: Xiamen University, Biochemistry and Molecular Biology 2000-2004 B.S.: Nanchang University, Biological Sciences
Work Experience	2019-present - Xiamen University - Associate Professor 2011-2019 - Xiamen University - Assistant Professor 2009-2011 - National Institutes of Health, USA - Joint PhD student

University/Lab Affiliation and Title

Xiamen University

Faculty

Life Sciences

Academic Background & Achievements

2005-2011 Ph.D.: Xiamen University, Biochemistry and Molecular Biology
2000-2004 B.S.: Nanchang University, Biological Sciences

Work Experience

2019-present - Xiamen University - Associate Professor
2011-2019 - Xiamen University - Assistant Professor
2009-2011 - National Institutes of Health, USA - Joint PhD student

Areas of Focus	Molecular mechanism of virulence involved in Plasmodium-host interactions Genetic basis of drug resistance in malaria parasite Mechanisms that control the parasite development at different stages
Publications	Deaggregation of mutant Plasmodium yoelii de-ubiquitinase UBP1 alters MDR1 localization to confer multidrug resistance., Xu R#, Lin L#, Jiao Z, Liang R, Guo Y, Zhang Y, Shang X, Wang Y, Wang X, Yao L, Liu S, Deng X, Yuan J, Su X-z, Li J, 2024 Human ApoE2 protects mice against Plasmodium berghei ANKA experimental cerebral malaria., Liang R#, Rao H#, Pang Q, Xu R, Jiao Z, Lin L, Li L, Zhong L, Zhang Y, Guo Y, Xiao N, Liu S, Chen X-F, Su X-z, Li J, 2023 Inner membrane complex proteomics reveals a palmitoylation regulation critical for intraerythrocytic development of malaria parasite., Qian P#, Wang X#, Zhong C-Q#, Wang J#, Cai M, Nguitragoo W, Li J, Cui H, Yuan J, 2022 The hepatic AMPK-TET1-SIRT1 axis regulates glucose homeostasis., Zhang C#, Zhong T#, Li Y#, Li X#, Yuan X, Liu L, Wu W, Wu J, Wu Y, Liang R, Xie X, Kang C, Liu Y, Lai Z, Xiao J, Tang Z, Jin R, Wang Y, Xiao Y, Zhang J, Li J, Liu Q, Sun Z, Zhong J, 2021 Generation and functional characterisation of Plasmodium yoelii csp deletion mutants using a microhomology-based CRISPR/Cas9 method., Xu R, Liu Y, Fan R, Liang R, Yue L, Liu S, Su X-z, Li J, 2019 A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence., Nair SC#, Xu R#, Pattaradilokrat S, Wu J, Qi Y, Zilversmit M, Ganesan S, Nagarajan V, Eastman RT, Orandle MS, Tan JC, Myers TG, Liu S, Long CA, Li J, Su X-z, 2017 Artemisinin and malaria: Current understandings of drug activation, action, and resistance., Su XZ, Li J., 2017 Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality., Yu X#, Cai B#, Wang M, Tan P, Ding X, Wu J, Li J, Li Q, Liu P, Xing C, Wang HY, Su X-z, Wang R-F, 2016 UTR introns, antisense RNA and differentially spliced transcripts between Plasmodium yoelii subspecies., Li J, Cai B, Qi Y, Zhao W, Liu J, Xu R, Pang Q, Tao Z, Hong L, Liu S, Leerkes M, Quiñones M, Su X-z, 2016 Regulation of Plasmodium yoelii Oocyst Development by Strain- and Stage-Specific Small-Subunit rRNA., Qi Y, Zhu F, Eastman RT, Fu Y, Zilversmit M, Pattaradilokrat S, Hong L, Liu S, McCutchan TF, Pan W, Xu W, Li J, Huang F, Su X-z, 2015 Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality., Wu J, Tian L, Yu X, Pattaradilokrat S, Li J, Wang M, Yu W, Qi Y, Zeituni AE, Nair SC, Crampton SP, Orandle MS, Bolland SM, Qi CF, Long CA, Myers TG, Coligan JE, Wang R, Su X-z, 2014 Chemical genomics for studying parasite gene function and interaction., Li J, Yuan J, Chen CC, Inglese J, Su X-z, 2013 Linkage maps from multiple genetic crosses and loci linked to growth-related virulent phenotype in Plasmodium yoelii., Li J#, Pattaradilokrat S#, Zhu F#, Jiang H, Liu S, Hong L, Fu Y, Koo L, Xu W, Pan W, Carlton JM, Kaneko O, Carter R, Wootton JC, Su X-z, 2011 Hundreds of microsatellites for genotyping Plasmodium yoelii parasites., Li J, Zhang Y, Liu S, Hong L, Sullivan M, McCutchan TF, Carlton JM, Su X-z, 2009 Typing Plasmodium yoelii microsatellites using a simple and affordable fluorescent labeling method., Li J, Zhang Y, Sullivan M, Hong L, Huang L, Lu F, McCutchan TF, Su X-z*, 2007

Areas of Focus

Molecular mechanism of virulence involved in Plasmodium-host interactions
Genetic basis of drug resistance in malaria parasite
Mechanisms that control the parasite development at different stages

Publications

Deaggregation of mutant Plasmodium yoelii de-ubiquitinase UBP1 alters MDR1 localization to confer multidrug resistance., Xu R#, Lin L#, Jiao Z, Liang R, Guo Y, Zhang Y, Shang X, Wang Y, Wang X, Yao L, Liu S, Deng X, Yuan J*, Su X-z*, Li J*, 2024
Human ApoE2 protects mice against Plasmodium berghei ANKA experimental cerebral malaria., Liang R#, Rao H#, Pang Q, Xu R, Jiao Z, Lin L, Li L, Zhong L, Zhang Y, Guo Y, Xiao N, Liu S, Chen X-F*, Su X-z*, Li J*, 2023
Inner membrane complex proteomics reveals a palmitoylation regulation critical for intraerythrocytic development of malaria parasite., Qian P#, Wang X#, Zhong C-Q#, Wang J#, Cai M, Nguitragoo W, Li J*, Cui H*, Yuan J*, 2022
The hepatic AMPK-TET1-SIRT1 axis regulates glucose homeostasis., Zhang C#, Zhong T#, Li Y#, Li X#, Yuan X, Liu L, Wu W, Wu J, Wu Y, Liang R, Xie X, Kang C, Liu Y, Lai Z, Xiao J, Tang Z, Jin R, Wang Y, Xiao Y, Zhang J, Li J*, Liu Q*, Sun Z*, Zhong J*, 2021
Generation and functional characterisation of Plasmodium yoelii csp deletion mutants using a microhomology-based CRISPR/Cas9 method., Xu R, Liu Y, Fan R, Liang R, Yue L, Liu S, Su X-z*, Li J*, 2019
A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence., Nair SC#, Xu R#, Pattaradilokrat S, Wu J, Qi Y, Zilversmit M, Ganesan S, Nagarajan V, Eastman RT, Orandle MS, Tan JC, Myers TG, Liu S, Long CA, Li J*, Su X-z*, 2017
Artemisinin and malaria: Current understandings of drug activation, action, and resistance., Su XZ*, Li J., 2017
Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality., Yu X#, Cai B#, Wang M, Tan P, Ding X, Wu J, Li J, Li Q, Liu P, Xing C, Wang HY, Su X-z*, Wang R-F*, 2016
UTR introns, antisense RNA and differentially spliced transcripts between Plasmodium yoelii subspecies., Li J*, Cai B, Qi Y, Zhao W, Liu J, Xu R, Pang Q, Tao Z, Hong L, Liu S, Leerkes M, Quiñones M, Su X-z*, 2016
Regulation of Plasmodium yoelii Oocyst Development by Strain- and Stage-Specific Small-Subunit rRNA., Qi Y, Zhu F, Eastman RT, Fu Y, Zilversmit M, Pattaradilokrat S, Hong L, Liu S, McCutchan TF, Pan W, Xu W, Li J*, Huang F*, Su X-z*, 2015
Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality., Wu J, Tian L, Yu X, Pattaradilokrat S, Li J, Wang M, Yu W, Qi Y, Zeituni AE, Nair SC, Crampton SP, Orandle MS, Bolland SM, Qi CF, Long CA, Myers TG, Coligan JE, Wang R*, Su X-z*, 2014
Chemical genomics for studying parasite gene function and interaction., Li J, Yuan J, Chen CC, Inglese J, Su X-z*, 2013
Linkage maps from multiple genetic crosses and loci linked to growth-related virulent phenotype in Plasmodium yoelii., Li J#, Pattaradilokrat S#, Zhu F#, Jiang H, Liu S, Hong L, Fu Y, Koo L, Xu W, Pan W, Carlton JM, Kaneko O, Carter R, Wootton JC, Su X-z*, 2011
Hundreds of microsatellites for genotyping Plasmodium yoelii parasites., Li J, Zhang Y, Liu S, Hong L, Sullivan M, McCutchan TF, Carlton JM, Su X-z*, 2009
Typing Plasmodium yoelii microsatellites using a simple and affordable fluorescent labeling method., Li J, Zhang Y, Sullivan M, Hong L, Huang L, Lu F, McCutchan TF, Su X-z*, 2007

Plasmodium Host Interactions Virulence Molecular Mechanism Drug Resistance Genetic Basis Malaria Parasite Development Stages Control Mechanisms

Changbin Chen - University of Chinese Academy of Sciences

Yangbo Hu - University of Chinese Academy of Sciences

Jing Yuan - Xiamen University

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